SEATTLE The Howard Hughes Medical Research Institute today announced that two researchers at Fred Hutchinson Cancer Research Center are among 50 scientists nationwide to be appointed HHMI Early Career Scientists.
Harmit Singh Malik, Ph.D., an associate member of the Center's Basic Sciences Division, and Toshiyasu Taniguchi, M.D., Ph.D., an assistant member in the Center's Human Biology and Public Health Sciences divisions, each will receive a six-year appointment to the HHMI and, along with it, the freedom to explore his or her best ideas without worrying about where to find the money to fund the work. Each will receive $1.5 million over the six-year appointment. The Institute will also cover other expenses, including research space and the purchase of critical equipment.
"These scientists are at the early stage of their careers, when they are full of energy and not afraid to try something new," said Jack Dixon, HHMI vice president and chief scientific officer. "They have already demonstrated that they are not apt to play it safe and we hope they will continue to do something really original."
Malik, an evolutionary biologist, sees conflicts raging within a cell's nucleus as genes jockey for evolutionary dominance. These clashes can have a long-term impact on organisms, as they sometimes alter the function of essential genes. Malik uses biochemistry and genomics to study the causes and consequences of these genetic conflicts in yeast, fruit flies and other model organisms. His work has offered novel explanations for host-pathogen interactions and for the evolution of structural DNA elements (centromeres) that are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because our defenses evolved to f
|Contact: Kristen Woodward|
Fred Hutchinson Cancer Research Center