Navigation Links
Two Hutchinson Center researchers named HHMI Early Career Scientists

SEATTLE The Howard Hughes Medical Research Institute today announced that two researchers at Fred Hutchinson Cancer Research Center are among 50 scientists nationwide to be appointed HHMI Early Career Scientists.

Harmit Singh Malik, Ph.D., an associate member of the Center's Basic Sciences Division, and Toshiyasu Taniguchi, M.D., Ph.D., an assistant member in the Center's Human Biology and Public Health Sciences divisions, each will receive a six-year appointment to the HHMI and, along with it, the freedom to explore his or her best ideas without worrying about where to find the money to fund the work. Each will receive $1.5 million over the six-year appointment. The Institute will also cover other expenses, including research space and the purchase of critical equipment.

"These scientists are at the early stage of their careers, when they are full of energy and not afraid to try something new," said Jack Dixon, HHMI vice president and chief scientific officer. "They have already demonstrated that they are not apt to play it safe and we hope they will continue to do something really original."

Malik, an evolutionary biologist, sees conflicts raging within a cell's nucleus as genes jockey for evolutionary dominance. These clashes can have a long-term impact on organisms, as they sometimes alter the function of essential genes. Malik uses biochemistry and genomics to study the causes and consequences of these genetic conflicts in yeast, fruit flies and other model organisms. His work has offered novel explanations for host-pathogen interactions and for the evolution of structural DNA elements (centromeres) that are critical for proper cell division. For example, to explore why humans are susceptible to HIV, Malik and his colleagues resurrected an extinct retrovirus that infected chimps and gorillas, but not humans, 4 million years ago. Malik's research suggests that we may be vulnerable to HIV infection because our defenses evolved to fight off other viruses instead. Recently, Malik and colleagues have shown that host proteins can evolve to defeat "viral mimicry," providing yet another nuance to a never-ending "arms race" between hosts and viruses.

Taniguchi, as a physician in Tokyo, treated many lymphoma patients with DNA-damaging chemotherapy, only to watch the drugs lose their power as the tumors developed resistance. He then became a researcher in cancer genetics to find ways to save more patients. At the Hutchinson Center, Taniguchi studies the role of DNA repair in promoting drug resistance in cancer cells. He identified a repair pathway that is often inactivated in patients with breast and ovarian cancers, as well as the childhood predisposition to cancer known as Fanconi anemia. Reactivation of the pathway, he discovered, can help tumors become resistant to chemotherapy drugs. Taniguchi intends to dig deeper into this mechanism of drug resistance and use the information he uncovers to develop drugs that will re-sensitize tumors to cancer therapies.

Malik and Taniguchi will begin their six-year, nonrenewable HHMI appointments in September 2009. The Institute anticipates another Early Career Scientist competition in 2012.


Contact: Kristen Woodward
Fred Hutchinson Cancer Research Center

Related biology news :

1. Uvalde Center water research could have national, international applications
2. NIH funds research center for womens reproductive health at Einstein
3. Stevens Center for Science Writings presents: Ravens at the Feast, with Bernd Heinrich, April 1
4. Bioscience institutions come together to launch Microlife Discovery Center for area students
5. Oceans journey towards the center of the Earth
6. Texas Obesity Research Center at UH assembles researchers to discuss obesity
7. Queens receives $9.1 million to establish National Center of Excellence in green chemistry
8. Public Policy Center hosts flood symposium March 10-12
9. NSF to fund water and environment technology center
10. NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis
11. Statement by the Egg Nutrition Center and American Egg Board on Diabetes Care study on egg consumption
Post Your Comments:
(Date:11/19/2015)... YORK , Nov. 19, 2015  Although some ... market is dominated by a few companies, according to ... companies own 51% of the market share of the ... The World Market for Molecular Diagnostic s ... "The market is still controlled by one company ...
(Date:11/17/2015)... LIVERMORE, Calif. , Nov. 17, 2015  Vigilant ... has joined its Board of Directors. ... Vigilant,s Board after recently retiring from the partnership at ... owning 107 companies with over $140 Billion in revenue.  ... performance improvement across all the TPG companies, from 1997 ...
(Date:11/12/2015)... , Nov. 11, 2015   Growing need ... analytical tools has been paving the way for ... determination of discrete analytes in clinical, agricultural, environmental, ... being predominantly used in medical applications, however, their ... sectors due to continuous emphasis on improving product ...
Breaking Biology News(10 mins):
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... Program that includes over 2,000 technical presentations offered in symposia, oral sessions, ... and applied spectroscopy, covers a wide range of applications such as, but not ...
(Date:11/25/2015)... ANNAPOLIS, Md. , Nov. 25, 2015  PharmAthene, ... of Directors has adopted a stockholder rights plan (Rights ... its net operating loss carryforwards (NOLs) under Section 382 ... --> --> PharmAthene,s use of its ... an "ownership change" as defined in Section 382 of ...
(Date:11/25/2015)... QUEBEC CITY , Nov. 25, 2015 /PRNewswire/ ... "Company"), affirms that its business and prospects remain ... , Zoptrex™ (zoptarelin doxorubicin) recently received DSMB ... program to completion following review of the final ... met Phase 2 Primary Endpoint in men with ...
(Date:11/24/2015)... 24, 2015  Asia-Pacific (APAC) holds the third-largest ... market. The trend of outsourcing to low-cost locations ... higher volume share for the region in the ... margins in the CRO industry will improve. ... ( ), finds that the market earned ...
Breaking Biology Technology: