Navigation Links
Twisting molecules by brute force: A top-down approach
Date:12/14/2011

CLEVELAND Molecules that are twisted are ubiquitous in nature, and have important consequences in biology, chemistry, physics and medicine. Some molecules have unique and technologically useful optical properties; the medicinal properties of drugs depend on the direction of the twist; and within us think of the double helix twisted DNA can interact with different proteins.

This twisting is called chirality and researchers at Case Western Reserve University have found they can use a macroscopic brute force to impose and induce a twist in an otherwise non-chiral molecule.

Their new "top-down" approach is described in the Dec. 2 issue of Physical Review Letters.

"The key is that we used a macroscopic force to create chirality down to the molecular level," said Charles Rosenblatt, professor of physics at Case Western Reserve and the senior author on the paper. Rosenblatt started the research with no application in mind. He simply wanted to see if it could be done essentially scientific acrobatics.

But, he points out, since antiquity chirality has played a role in health, energy, technology and more but until now, chirality always has been a bottom-up phenomenon. This new top-down approach, if it can be scaled up, could lead to custom designed chirality - and therefore desired properties - in all kinds of things.

Rosenblatt worked with post-doctoral researcher Rajratan Basu, graduate student Joel S. Pendery, and professor Rolfe G. Petschek, of the physics department at Case Western Reserve, and Chemistry Professor Robert P. Lemieux of Queen's University, Kingston, Ontario.

Chirality isn't as simple as a twist in a material. More precisely, a chiral object can't be superimposed on its mirror image. In a "thought experiment", if one's hand can pass through a mirror (like Alice Through the Looking Glass), the hand cannot be rotated so that it matches its mirror image. Therefore one's hand is chiral.

Depending on the twist, scientists define chiral objects as left-handed and right-handed. Objects that can superimpose themselves on their mirror image, such as a wine goblet, are not chiral.

In optics, chiral molecules rotate the polarization of light the direction depends on whether the molecules are left-handed or right-handed. Liquid crystal computer and television screen manufacturers take advantage of this property to enable you to clearly see images from an angle.

In the drug industry, chirality is crucial.

Two drugs with the identical chemical formula have different uses. Dextromethorphan, which is right-handed, is a cough syrup and levomethorphan, which is lefthanded, is a narcotic painkiller.

The reason for the different effects? The drugs interact differently with biomolecules inside us, depending on the biomolecules' chirality.

After meeting with Lemieux at a conference, the researchers invented a method to create chirality in a liquid crystal at the molecular level.

They treated two glass slides so that cigar-shaped liquid crystal molecules would align along a particular direction. They then created a thin cell with the slides, but rotated the two alignment directions by approximately a 20 degree angle.

The 20-degree difference caused the molecules' orientation to undergo a right-handed helical rotation, like a standard screw, from one side to the other. This is the imposed chiral twist.

The twist, however, is like a tightened spring and costs energy to maintain. To reduce this cost, some of the naturally left-handed molecules in the crystal became right-handed. That's because, inherently, right-handed molecules give rise to a macroscopic right-handed twist, Rosenblatt explained. This shift of molecules from left-handed to right-handed is the induced chirality.

Although the law of entropy suggests there would be nearly identical numbers of left-handed and right-handed molecules, in order to keep total energy cost at a minimum, the right-handed molecules outnumbered the left, he said.

To test for chirality, the researchers applied an electrical field perpendicular to the molecules. If there were no chirality, there would be nothing to see. If there were chirality, the helical twist would rotate in proportion to the amount of right-handed excess.

They observed a modest rotation, which became larger when they increased the twist.

"The effect was occurring everywhere in the cell, but was strongest at the surface," Rosenblatt said.

Scientists have built chirality into optical materials, electrooptic devices, and more by starting at the molecular level. But the researchers are not aware of other techniques that use a macroscopic force to bring chiralty down to molecules.

The researchers are continuing to investigate ways this can be done.


'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Related biology news :

1. RNA molecules, delivery system improve vaccine responses, effectiveness
2. Bare bones of crystal growth: Biomolecules enhance metal contents in calcite
3. Linking Proteins, Wires, Dots, and Molecules into Useful Devices
4. Argonne scientists discover possible mechanism for creating handedness in biological molecules
5. Molecules in the spotlight
6. Shape changes in aroma-producing molecules determine the fragrances we detect
7. Researchers unzip molecules to measure interactions keeping DNA packed in cells
8. Measuring molecules to improve drug design
9. Engineers create intelligent molecules that seek-and-destroy diseased cells
10. New models question old assumptions about how many molecules it takes to control cell division
11. Scripps research team identifies key molecules that inhibit viral production
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... , Feb. 22, 2017 With the ... ABI Research identifies four technologies that innovative and ... secure significant share in the changing competitive landscape: ... passive authentication.   "Companies can no ... to security," says Dimitrios Pavlakis , Industry ...
(Date:2/21/2017)... LONDON , February 21, 2017 ... um 70 Millionen US-Dollar wachsen. Nach einem Gespräch mit mehr ... es einige Hindernisse zu überwinden gilt, um diese Prognose ... ... unter anderem die Mobilisierung der finanziellen Mittel für die ...
(Date:2/14/2017)... Feb. 14, 2017  Wake Forest Baptist Medical Center ... new chief executive officer (CEO). Freischlag joins the medical ... D. McConnell , M.D., who last year announced that ... Medical Center, after leading it since 2008.   ... of Wake Forest Baptist,s academic health system, which includes ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... Malden, MA (PRWEB) , ... March 23, 2017 ... ... as, “a viscoelastic material that exhibits both viscous and elastic characteristics when deformed, ... AxioMed disc polymer exhibits properties to gently absorb compressive forces and return to ...
(Date:3/23/2017)... Mass. , March 23, 2017 /PRNewswire/ ... partner to global in vitro diagnostics manufacturers ... of the industry,s first multiplexed Inherited ... disease testing by next-generation sequencing (NGS). The ... were developed with input from industry experts ...
(Date:3/23/2017)... , March 23, 2017 Kineta, ... development of novel therapies in immuno-oncology, today announced ... lead" small molecule compounds that activate interferon response ... pathways and demonstrate immune-mediated tumor regression in a ... the study who demonstrated complete tumor regression to ...
(Date:3/23/2017)... 23, 2017 In today,s pre-market ... in the Biotech industry: Sangamo Therapeutics Inc. (NASDAQ: SGMO), ... MKT: SYN), and Regulus Therapeutics Inc. (NASDAQ: ... Credit Suisse upgraded its rating on Pharmaceuticals/Biotechnology to "Overweight" from "Market Weight." ... report at: ...
Breaking Biology Technology: