Navigation Links
Twin nanoparticle shown effective at targeting, killing breast cancer cells
Date:3/10/2009

PROVIDENCE, R.I. [Brown University] Breast cancer patients face many horrors, including those that arise when fighting the cancer itself. Medications given during chemotherapy can have wicked side effects, including vomiting, dizziness, anemia and hair loss. These side effects occur because medications released into the body target healthy cells as well as tumor cells.

The trick becomes how to deliver cancer-fighting drugs directly to the tumor cells. Brown University chemists think they have an answer: They have created a twin nanoparticle that specifically targets the Her-2-positive tumor cell, a type of malignant cell that affects up to 30 percent of breast cancer patients.

The combination nanoparticle binds to the Her-2 tumor cell and unloads the cancer-fighting drug cisplatin directly into the infected cell. The result: Greater success at killing the cancer while minimizing the anti-cancer drug's side effects.

"Like a missile, you don't want the anti-cancer drugs to explode everywhere," explained Shouheng Sun, a chemistry professor at Brown University and an author on the paper published online in The Journal of the American Chemical Society. "You want it to target the tumor cells and not the healthy ones."

The researchers created the twin nanoparticle by binding one gold (Au) nanoparticle with an iron-oxide (Fe3O4) nanoparticle. On one end, they attached a synthetic protein antibody to the iron-oxide nanoparticle. On the other end, they attached cisplatin to the gold nanoparticle. Visually, the whole contraption looks like an elongated dumbbell, but it may be better to think of it as a vehicle, equipped with a very good GPS system, that is ferrying a very important passenger.

In this case, the GPS comes from the iron-oxide nanoparticle, which homes in on a Her-2 breast-cancer cell like a guided missile. The attached antibody is critical, because it binds to the antigen, a protein located on the surf
'/>"/>

Contact: Richard Lewis
Richard_Lewis@Brown.edu
401-863-3766
Brown University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
2. New nanoparticle vaccine is more effective but less expensive
3. Nanoparticle exposures happen, says expert
4. MIT: Remote-control nanoparticles deliver drugs directly into tumors
5. Technique controls nanoparticle size, makes large numbers
6. Astronomy technology brings nanoparticle probes into sharper focus
7. Researchers mimic bacteria to produce magnetic nanoparticles
8. Environmental fate of nanoparticles depends on properties of water carrying them
9. Nanoparticles assemble by millions to encase oil drops
10. MIT: Stripes key to nanoparticle drug delivery
11. New ORNL process brings nanoparticles into focus
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Twin nanoparticle shown effective at targeting, killing breast cancer cells
(Date:4/16/2014)... ,, Imagine you cannot move your eyes up, and you cannot ... tilted upward so that your eyes look straight when they are ... be corrected to allow people a normal position of their head. ... why this happens. , In a paper published in the April ...
(Date:4/16/2014)... bulbar muscular atrophy (SBMA) is a rare inherited neuromuscular disorder ... long considered it to be essentially an affliction of primary ... brainstem that control muscle movement. , But in a new ... Neuron , a team of scientists at the University ...
(Date:4/16/2014)... array of finger-like projections called microvilli covers the ... University researchers have now discovered how intestinal cells build ... and defending against pathogens. The findings, published April 10 ... for adhesion molecules in brush border assembly and increase ...
Breaking Biology News(10 mins):Researchers track down cause of eye mobility disorder 2Mutant protein in muscle linked to neuromuscular disorder 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 2Vanderbilt researchers discover how intestinal cells build nutrient-absorbing surface 3
... A study led by St. Jude Children,s Research Hospital has ... of nerve cells in amyotrophic lateral sclerosis (ALS), also known ... same mutation occurred in both genes and led to the ... an essential role in normal RNA functioning and have also ...
... An international group of researchers has discovered seven ... with increased risk of age-related macular degeneration (AMD), a ... network of international investigators representing 18 research groups, also ... which is published online in Nature Genetics ...
... CHAMPAIGN, Ill. A study published in the journal ... late 1800s in West Central Illinois. The study could not ... says a co-author of the new research., Charles Robertson, a ... and the University of Illinois, was one of the first ...
Cached Biology News:2 new genes linked to amyotrophic lateral sclerosis and related disorders 22 new genes linked to amyotrophic lateral sclerosis and related disorders 3International consortium discovers seven new genomic regions associated with AMD 2International consortium discovers seven new genomic regions associated with AMD 3Illinois town provides a historical foundation for today's bee research 2
(Date:1/14/2014)... 14, 2014 Histogen, Inc., a regenerative ... cells grown under simulated embryonic conditions, today announced that ... Suneva Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s ... This agreement is an amendment to the existing license ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... Orange, CA (PRWEB) January 14, 2014 Kerr ... a 10-minute video and additional how-to information about dual arch ... Great Restorations with Dual Arch Impressions,” the blog entry serves ... the technique and houses a step-by-step demonstration by Dr. David ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3
... researchers have identified a class of high-strength metal alloys ... smaller and more responsive. The alloys could be ... loudspeakers, and components that boost the performance of medical ... engines. While these nanostructured metal alloys are not ...
... Reportlinker.com announces that a new market research report ... Three Alternative Scenarios of the Future In Vitro ... http://www.reportlinker.com/p0363585/Three-Alternative-Scenarios-of-the-Future-In-Vitro-Diagnostics-Market-through-2018.html This report is ... and R&D executives. The report is designed to ...
... N.J., March 9, 2011 Palatin Technologies, Inc. (NYSE Amex: ... at the ROTH 23rd Annual OC Growth Stock Conference on ... conference will be held at the Ritz Carlton Laguna Niguel ... President and Chief Executive Officer of Palatin Technologies, will provide ...
Cached Biology Technology:Rutgers researchers identify materials that may deliver more 'bounce' 2Reportlinker Adds Three Alternative Scenarios of the Future In Vitro Diagnostics Market through 2018 2
... Immulon 2HB ELISA strips, high binding ... affinity for hydrophilic proteins and complexes. ... for reagent injection while providing the ... Each strip accomodates 12 wells., ...
...
Ethylene glycol-bis(2-aminoethyl ether)-N,N,N',N'-tetraacetic acid, Molecular Biology Grade...
... efficiencies and the chemistry of light production ... benefit that they require simple triggering conditions ... This benefit has been exploited to great ... compounds can also be easily modified to ...
Biology Products: