Navigation Links
Turning human stem cells into brain cells sheds light on neural development
Date:5/2/2013

Medical researchers have manipulated human stem cells into producing types of brain cells known to play important roles in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The new model cell system allows neuroscientists to investigate normal brain development, as well as to identify specific disruptions in biological signals that may contribute to neuropsychiatric diseases.

Scientists from The Children's Hospital of Philadelphia and the Sloan-Kettering Institute for Cancer Research led a study team that described their research in the journal Cell Stem Cell, published online today.

The research harnesses human embryonic stem cells (hESCs), which differentiate into a broad range of different cell types. In the current study, the scientists directed the stem cells into becoming cortical interneuronsa class of brain cells that, by releasing the neurotransmitter GABA, controls electrical firing in brain circuits.

"Interneurons act like an orchestra conductor, directing other excitatory brain cells to fire in synchrony," said study co-leader Stewart A. Anderson, M.D., a research psychiatrist at The Children's Hospital of Philadelphia. "However, when interneurons malfunction, the synchrony is disrupted, and seizures or mental disorders can result."

Anderson and study co-leader Lorenz Studer, M.D., of the Center for Stem Cell Biology at Sloan-Kettering, derived interneurons in a laboratory model that simulates how neurons normally develop in the human forebrain.

"Unlike, say, liver diseases, in which researchers can biopsy a section of a patient's liver, neuroscientists cannot biopsy a living patient's brain tissue," said Anderson. Hence it is important to produce a cell culture model of brain tissue for studying neurological diseases. Significantly, the human-derived cells in the current study also "wire up" in circuits with other types of brain cells taken from mice, when cultured togeth
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Returning military personnel to duty following severe injury to the lower extremity
2. Researchers find molecular switch turning on self-renewal of liver damage
3. AZTI-Tecnalia is turning vegetable by-products destined for landfills into feedstuff
4. Zebrafish may hold the answer to repairing damaged retinas and returning eyesight to people
5. Why astronauts experience low blood pressure after returning to Earth from space
6. Turning ideas into products faster
7. Turning down the dial: Ocean energy development with less sound
8. Turning off small RNA
9. OGIs investment in cytognomix contributes to the Shannon Human Splicing Pipelines success
10. CNIO researchers capture the replication of the human genome for the first time
11. Source identification of H7N9 influenza virus causing human infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 13, 2015 Technology Showcase, Hall E ... identity authentication solutions, today announced it will showcase its EyeLock ... developed by the Department of Energy,s Oak Ridge National ... Auto Show . EyeLock,s iris identity authentication technology is being ...
(Date:1/22/2015)... , Jan. 16, 2015  A man-made form of insulin ... other mental capabilities in adults with mild cognitive impairment ... led by researchers at Wake Forest Baptist Medical Center. ... with amnesic mild cognitive impairment (MCI) or mild to ...
(Date:1/22/2015)... POINT ROBERTS, Washington , January 20, 2015 ... including technology and tech stocks, releases video from the CES ... and security consultant Apollo Robbins . Apollo ... the Wocket™ biometric smart wallet, a product of NXT-ID, Inc. ...
Breaking Biology News(10 mins):EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 2Apollo Robbins Talks about the Illusion of Personal Safety and How Easily Your Wallet is Stolen; If a Wocket Wallet is Stolen the Thief Can't do Anything With it! 3
... heredity is revealing, and two scientists who,ve studied the ... what,s most revealing to them is how fast both ... research assistant professor of biological sciences at the University ... and conservation biologist at the Chicago Zoological Society, compared ...
... 19 October 2007: Scientists have found that a large ... pre-disposition to the disease. The disease is the most ... common cause of admission to hospital in the first year ... 1,000 babies are admitted to hospital for bronchiolitis - needing ...
... to track one,s DNA to a specific country, region ... But while the popularity of genetic ancestry testing is ... is flawed and could spawn unwelcome societal consequences, according ... of California, Berkeley. "Because race has such profound ...
Cached Biology News:Mice roar message: genetic change happens fast 2Scientists find predisposition to bronchiolitis in some babies 2Genetic ancestral testing cannot deliver on its promise, study warns 2Genetic ancestral testing cannot deliver on its promise, study warns 3Genetic ancestral testing cannot deliver on its promise, study warns 4
(Date:1/22/2015)... 22 de enero de 2015  El Dr. Paul ... llamada a nominaciones para 2015. Este prestigioso premio reconoce ... tiene el potencial para hacer, contribuciones destacadas para la ... hasta el 15 de marzo de 2015 a través ...
(Date:1/22/2015)... 22, 2015   GenoSpace , a precision medicine software company ... the broad use of genomic, imaging and other biomedical data ... Michelle Munson , CEO of Aspera, an IBM Company, ... - http://photos.prnewswire.com/prnh/20150122/170713 "We are pleased ...
(Date:12/24/2014)... 2014  United Therapeutics Corporation (NASDAQ: UTHR ) ... ) has submitted a pre-market approval application to the ... of Medtronic,s SynchroMed ® II implantable drug infusion ... United Therapeutics, Remodulin ® (treprostinil) Injection delivered intravenously ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... for cells and tissues  ("BioLife" or the "Company"), today ... Stockholders on May 4, 2015 (the "Annual Meeting"). ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4GenoSpace Expands Board with Appointment of Michelle Munson 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2
... 10 Essilor,of America, Essilor International,s US subsidiary, ... States with the acquisition,of Interstate Optical Co., one ... laboratories in Mansfield, Ohio and,Indianapolis, Indiana serve eye ... sales of US$26 million and 210 employees., ...
... 9 Hagens Berman Sobol Shapiro LLP,( ... business practices of CellCyte (OTC Bulletin Board: ... The investigation comes after CellCyte,s shares plunged ... in CellCyte CEO Gary,Reys, educational and professional ...
... Omeros Corporation announced today that,it has filed a ... the proposed initial public offering of shares of,its common ... sold in the offering,will be offered by Omeros. Deutsche ... manager. Pacific Growth Equities, LLC will be acting,as the ...
Cached Biology Technology:Hagens Berman Sobol Shapiro Investigating CellCyte 2Omeros Corporation Files Registration Statement for Proposed Initial Public Offering 2
... Imaging System, Professional Package Superior Protein ... Range: The ProXPRESS 2D Proteomic Imaging System ... for both proteomic and general life science ... enabling the use of all dyes in ...
... spatulas have been designed to save time ... those interested in eliminating the recycling and ... is individually packaged, RNase/DNase free, non-pyrogenic and ... new product number, created to easily match ...
... three-way universal digital valve, just 8 mm in ... functional features in a single glass-reinforced, PBT (Polybutylene ... 8mm in width. , Meets a range of ... psi. , Satisfies a 0.016 sccm leakage specification ...
... versatile system that simultaneously harvests and washes ... into a solid filter supports for analysis ... counter. The FilterMate is ideal for the ... cell proliferation, receptor binding, nucleic acid degradation, ...
Biology Products: