Navigation Links
Turning bacteria into butanol biofuel factories
Date:3/2/2011

obe systems.

"We are in a host that is easier to work with, and we have a chance to make it even better," Chang said. "We are reaching yields where, if we could make two to three times more, we could probably start to think about designing an industrial process around it."

"We were excited to break through the multi-gram barrier, which was challenging," she added.

Among the reasons for engineering microbes to make fuels is to avoid the toxic byproducts of conventional fossil fuel refining, and, ultimately, to replace fossil fuels with more environmentally friendly biofuels produced from plants. If microbes can be engineered to turn nearly every carbon atom they eat into recoverable fuel, they could help the world achieve a more carbon-neutral transportation fuel that would reduce the pollution now contributing to global climate change. Chang is a member of UC Berkeley's year-old Center for Green Chemistry.

The basic steps evolved by Clostridium to make butanol involve five enzymes that convert a common molecule, acetyl-CoA, into n-butanol. Other researchers who have engineered yeast or E. coli to produce n-butanol have taken the entire enzyme pathway and transplanted it into these microbes. However, n-butanol is not produced rapidly in these systems because the native enzymes can work in reverse to convert butanol back into its starting precursors.

Chang avoided this problem by searching for organisms that have similar enzymes, but that work so slowly in reverse that little n-butanol is lost through a backward reaction.

"Depending on the specific way an enzyme catalyzes a reaction, you can force it in the forward direction by reducing the speed at which the back reaction occurs," she said. "If the back reaction is slow enough, then the transformation becomes effectively irreversible, allowing us to accumulate more of the final product."

Chang found two new enzyme versions in published sequ
'/>"/>

Contact: Robert Sanders
rsanders@berkeley.edu
510-643-6998
University of California - Berkeley
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Turning freshwater farm ponds into crab farms
2. Pregnancy not turning minds to mush: Study
3. Turning over a new leaf for future energy supplies
4. Turning sunlight into liquid fuels
5. Duke technique is turning proteins into glass
6. Brain tumors: Tissue stem cell turning into tumor stem cell
7. Thesis analyzes factors responsible for the case of Basque natural cider turning bitter
8. Turning school ground natural areas into environmental labs
9. Discovery may lead to turning back the clock on ovarian cancer
10. Turning to nature for inspiration
11. Disinfectants can make bacteria resistant to treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Turning bacteria into butanol biofuel factories
(Date:8/1/2014)... of phloem, the conductive tissue through which plants transport ... cylindrical cells are capped at one end by a ... which in turn form a network throughout a plant,s ... cells which play an important role in carbon sequestration, ... their differentiation," says Professor Yk Helariutta from the Institute ...
(Date:8/1/2014)... Aug. 1, 2014  LiveScan Service Provider Binary Biometrics is pleased ... a result, Binary Biometrics will improve its mobile service capabilities and add more ... County and service several new cities such as, but not limited ... DeLand , Deltona , Edgewater ... New Smyrna Beach , Oak Hill , ...
(Date:7/31/2014)... Foundation (NSF), counters a widely-held scientific view that ... that certain Arctic lakes store more greenhouse gases ... The study, published this week in the journal ... occur as permafrost thaws and creates surface depressions ... was previously frozen land into lakes. , The ...
Breaking Biology News(10 mins):Developmental regulation of important plant phloem components discovered 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 2Binary Biometrics, Founded by James Timothy White, Expands Services to 13+ Locations With the Addition of Owner/Operator Kevin Morris 3Certain Arctic lakes store more greenhouse gases than they release 2
... The 2009 American Society for Microbiology Public ... reporters Michael Berens and Ken Armstrong for their ... (MRSA) in Washington State hospitals. The series, entitled ... the spread of epidemics such as MRSA infection ...
... diseases that starve eye tissue and nerves of oxygen ... researchers at Oak Ridge National Laboratory, the University of ... technique uses a new class of smart prosthetic implants ... oxygen because of restricted blood flow. This condition occurs ...
... high among people born in Scotland or Ireland compared with ... Research, conducted by the University of Edinburgh and the Office ... but living in England and Wales had similar ... The findings showed too that people born in parts of ...
Cached Biology News:Seattle Times reporters win ASM public communications award 2ORNL, Southern Cal set sights on preventing blindness 2Scots and Irish at greater risk of drink-related death, study shows 2
(Date:8/1/2014)... Applied DNA Sciences, Inc. (OTCQB: ... and product authentication solutions, will host a conference call ... third quarter results. The Quarterly Report on Form 10Q ... of the day on Monday August 11, 2014. ... conference call beginning at 9:00 A.M. Eastern Daylight Time ...
(Date:8/1/2014)... , Aug. 1, 2014 Research ... "The World Market for Flow Cytometry in ... http://photos.prnewswire.com/prnh/20130307/600769 ... are now an important component of advanced IVD ... instruments for cancer diagnostics, but their newer clinical ...
(Date:8/1/2014)... , Aug. 1. 2014 As one of ... 2014 AACC Annual Meeting & Clinical Lab Expo is ... patient care are introduced to the healthcare world. This ... Expo,s 650 exhibitors will include the latest diagnostic technology ... Advances in smartphones and biosensors have enabled the development ...
(Date:8/1/2014)... -- One of the major revolutions taking place in ... the practice of using genomic and other molecular analyses ... Personalized diagnostics—laboratory analyses that inform the practice of personalized ... This fall, AACC ,s first ever virtual ... exciting field and the novel technologies driving it forward, ...
Breaking Biology Technology:Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 2Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 3The World Market for Flow Cytometry in IVD Applications 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3First-Ever AACC Virtual Conference to Focus on Personalized Diagnostics 2
... (Nasdaq: SQNM ) today announced that Ronald ... development, will present an overview of the company at ... http://photos.prnewswire.com/prnh/20040415/SQNMLOGO ) (Logo:   http://www.newscom.com/cgi-bin/prnh/20040415/SQNMLOGO ) ... Healthcare Conference Location: The Palace Hotel, New ...
... 2, 2010 ... ... var shortURL = ... so we need to grab the first one. for (var r in data.results) { first_result = data.results[r]; ...
... LOUIS, Sept. 2 Sigma Life Science, the innovative ... (Nasdaq: SIAL ), today announced the global ... lines. This new product range combines Sigma,s proprietary CompoZr ... Company,s extensive experience in gene silencing, to offer innovative ...
Cached Biology Technology:Sequenom to Present at Two Financial Conferences in September 2Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 2Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 3Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 4Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 5Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 6Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 7Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 8Long Term Data Presented at ESC 2010 Further Support the Benefit of The CYPHER(R) Sirolimus Drug-Eluting Stent Compared to The ENDEAVOR(R) Zotarolimus-Eluting Stent in Important High-Risk Subgroups 9Sigma® Life Science Enters Genetically Modified Cell Market 2Sigma® Life Science Enters Genetically Modified Cell Market 3Sigma® Life Science Enters Genetically Modified Cell Market 4
ANTI-RAT ADHESION MARKERS, CDs, CYTOKINES, ETC Rat ICAM PE - Mouse IgG1...
Reacts with methylated DNA from plants and vertebrates...
...
Phospho-4E-BP1 (Thr37/46) (236B4) Rabbit mAb Shipping Temperature: Cold Storage Temperature: -20C...
Biology Products: