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Turmeric spices up virus study
Date:8/16/2012

ited about this work, as curcumin not only dramatically inhibits RVFV replication in cell culture but also demonstrates efficacy against RVFV in a mouse model."

Narayanan and her colleagues study the connection between a virus and how it impacts the host human or animal. Symptoms clue in the researcher about the body's inner workings. Rift Valley Fever and Venezuelan Equine Encephalitis kick off with flu-like symptoms.

Symptoms can make it challenging for someone to recover. The body usually starts with an exaggerated inflammatory response because it doesn't know where to start to rid itself of the virus, she says.

"Many times, the body goes above and beyond what is necessary," Narayanan says. "And that's not good because it's going to influence a bunch of cells around the infection, which haven't seen the bug. That's one way by which disease spreads through your body. And so it is very important to control the host because a lot of times the way the host responds contributes to the disease."

Controlling the symptoms means more than simply making the patients feels better. "You're giving the antiviral a chance to work. Now an antiviral can go in and stop the bug. You're no longer trying to keep the host alive and battling the bug at the same time."

Once Narayanan knows how the body responds to a virus, it's time to go after the bug itself. She's applying this know-how to a family of viruses called Bunyaviruses, which feature Rift Valley fever, and such alphaviruses as Venezuelan equine encephalitis and retroviruses, which notably include HIV.

She delves into uncovering why and how each virus affects the patient. "Why are some cell types are more susceptible to one type of infection than another?" HIV goes after the immune system. Bunyaviruses will infect a wide range of cells but do maximum damage to the liver. "What is it about the liver that makes it a sitting duck compared to something like the brain?
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Contact: Michele McDonald
mmcdon15@gmu.edu
703-993-8781
George Mason University
Source:Eurekalert

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