Navigation Links
Tuning into cell signals that tell where sensory organs will form inside the ear
Date:8/27/2010

Researchers have tracked a cell-to-cell signaling pathway that designates the future location of the ear's sensory organs in embryonic mice. The scientists succeeded in activating this signal more widely across the embryonic tissue that becomes the inner ear. Patches of sensory structures began growing in spots where they don't normally appear.

The structures contained tufted cells, called hair cells, which respond to sound waves and other sensations, and additional nerve cells that amplify or code sounds for the brain to interpret.

The results suggest an avenue for further investigation in restoring hearing loss from nerve damage.

The findings are reported this week in the early online edition of Proceedings of the National Academy of Sciences by researchers Byron H. Hartman, Thomas Reh, and Olivia Bermingham- McDonogh of the Department of Biological Structure at the University of Washington (UW) in Seattle. All three are members of the UW Institute for Stem Cells and Regenerative Medicine. The senior author, Bermingham-McDonogh, is also an affiliate of the UW Virginia Merrill Bloedel Hearing Research Center.

"As the population ages," said Bermingham-McDonogh, "there's a great interest in discovering how to regenerate the inner ear sensory cells that we need for our hearing and balance. Both of these falter as we get older -- we get hard of hearing and unsteady on our feet -- due to accumulated destruction of the sensory cells in the inner ear."

The goal of their research is to develop ways to restore inner ear sensory hair cells in people who have lost them due to age, excessive noise or other toxic damage. The hair cells do not spontaneously recover after they are lost, and adult stem cells have not been found in the mammalian inner ear. In order to devise a way to restart hair cell formation in the adult ear, Bermingham-McDonogh's group is studying how hair cells are made in the first place during e
'/>"/>

Contact: Leila Gray
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Migraine sufferers: More difficulty tuning out visual stimuli?
2. Tuning in on cellular communication in the fruit fly
3. Road signs and traffic signals on DNA
4. Using a pests chemical signals to control it
5. Size matters: Eavesdropping on sexual signals
6. New tool helps scientists see molecular signals of eye disease before symptoms arise
7. Scientists sever molecular signals that prolific parasite uses to puppeteer cells
8. Depression associated with sustained brain signals
9. Montana State researcher discovers that bile sends mixed signals to E. coli
10. Baby monkeys receive signals through their mothers breast milk
11. Concurrent imaging of metabolic and electric signals in the heart
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tuning into cell signals that tell where sensory organs will form inside the ear
(Date:9/15/2014)... GEOMAR Helmholtz Centre for Ocean Research Kiel and ... for the first time, that the single most ... Emiliania huxleyi , can adapt simultaneously to ocean ... the researchers found no evidence for the widespread ... of climate change would interfere with each other. ...
(Date:9/15/2014)... 100 feet long and weighing as much as 170 tons, ... and by far the heaviest living thing ever seen on ... common with the tiniest fish larvae, which measure millimeters in ... gram, right? , Not so fast, says L. Mahadevan, ... Organismic and Evolutionary Biology, and of Physics. , Using ...
(Date:9/15/2014)... , , , ... , , , , ... set of symptoms. The finding could be a first... , , ... , , , , , ... , , , , , , , New research shows that schizophrenia isn,t ...
Breaking Biology News(10 mins):Small algae with great potential 2Small algae with great potential 3The science behind swimming 2The science behind swimming 3Schizophrenia not a single disease but multiple genetically distinct disorders 2Schizophrenia not a single disease but multiple genetically distinct disorders 3Schizophrenia not a single disease but multiple genetically distinct disorders 4Schizophrenia not a single disease but multiple genetically distinct disorders 5
... can affect healthy people,s personality traits as well as ... reveals a thesis from the University of Gothenburg, Sweden. ... is responsible for defending humans against infection as well ... vital for our survival. Research has demonstrated that inflammatory ...
... for the French National Institute for Agricultural Research INRA ... Apidologie , Annals of Forest Sciences , ... Sustainable Development and Veterinary Research (all ... published by the prestigious institute have gained an excellent ...
... the lower the risk of developing low- and high-grade ... Biomarkers & Prevention , a journal of the American ... of Illinois at Chicago, used self-reported data on medically ... glioma and 612 cancer-free patients from Duke University and ...
Cached Biology News:Genes of the immune system are associated with increased risk of mental illness 2Springer and the French National Institute for Agricultural Research INRA team up 2Allergies lower risk of low- and high-grade glioma 2
(Date:9/15/2014)... researchers led by Northeastern University has developed a ... and a variety of nanocarbon structures in carbon ... scalable, which will allow the researchers to tailor ... in applications ranging from electronic devices to CNT-reinforced ... sports equipment. , Their findings were published in ...
(Date:9/15/2014)... DUBLIN , Sept. 15, 2014 Research ... "Whole Exome Sequencing Market by Product, by Services, by Technology, ... their offering. Whole Exome Sequencing (WES) is ... the genome, i.e. the exon. The exome, which is the ... of the total genome and is actually converted into proteins ...
(Date:9/15/2014)... , 15 septembre 2014 La ... Week (IPAW) (semaine internationale sur la sensibilisation ... octobre. Initiative conjointe de la Plasma Protein ... sociétés membres , l,IPAW vise à : ... sujet de la collecte du plasma-aphérèse , ...
(Date:9/14/2014)... 2014 UMBC’s Biotechnology Graduate Programs’ ... October 21, 2014, from 12:00 to 1:00 p.m. EDT. ... innovative curriculum and practice-oriented instruction, designed for working professionals. ... help advance their career in the biotechnology industry. , ... , About UMBC’s Biotechnology Graduate Programs, UMBC offers ...
Breaking Biology Technology:Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 2Global Whole Exome Sequencing (Systems, Kits, Library Preparation, Target Enrichment) Market by Product, by Services, by Technology, by Application - Forecast to 2018 3L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 2L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2
... INDIANAPOLIS, and SAN DIEGO, July 8 Eli Lilly,and ... (Nasdaq: SGXP ) today,announced that the companies have ... SGX in an all-cash transaction. SGX, based,in San Diego, ... development in the area of oncology. Under the terms ...
... in diagnostics, imaging, and ... ... Institute, and Case Western Reserve University today,announced the organizations will partner ... diagnostics, imaging and therapeutics,to improve medical treatment and patient care., ...
... July 8 Royalty Pharma is pleased to announce,that ... Vice,President, Head of Research. Dr. Reddoch has 17 years ... last 12 years as an equity analyst,most recently as ... Markets. He previously worked at Banc of America,Securities, and ...
Cached Biology Technology:Lilly to Acquire SGX Pharmaceuticals 2Lilly to Acquire SGX Pharmaceuticals 3Lilly to Acquire SGX Pharmaceuticals 4Lilly to Acquire SGX Pharmaceuticals 5NanoMedicine Summit Returns to Cleveland, September 25-26 2NanoMedicine Summit Returns to Cleveland, September 25-26 3NanoMedicine Summit Returns to Cleveland, September 25-26 4Royalty Pharma Announces that James Reddoch, Ph.D., Joins Management Team 2
...
... Monoclonal Anti-β-Tubulin IV Recognizes an ... sequence of β-tubulin isotype IV. ... isotypes is observed. ascites fluid ... C-terminal sequence of β-tubulin isotype ...
... Finnpipette BioControl is a major step ... complete liquid handling system - with ... tip cone modules. All five single ... modules fit one handle. The lightweight ...
... the joining of two strands of DNA ... of adjacent nucleotides in either a cohesive-ended ... also been shown to catalyze the joining ... RNA strand in a duplex molecule but ...
Biology Products: