Navigation Links
Tuning in on cellular communication in the fruit fly
Date:2/18/2009

s team found that when they disrupted the Kek5 protein in developing fruit flies their wings would not grow properly. Conversely, when Duffy's team engineered fruit fly cells to have too many copies of Kek5, the wings grew with defects. "It was pretty clear that Kek5 was regulating the BMP pathway, and that was an exciting observation," Duffy said.

The recent work on Kek5 follows earlier studies in the Duffy lab that revealed a related protein, Kek1, regulates the Epidermal Growth Factor (EGF) pathway, which is another important developmental pathway. Problems with the BMP and EGF pathways are implicated in cancer, bone disorders, heart disease, and neurodegenerative diseases. Developing compounds that can regulate or repair these pathways is an active area of therapeutic research.

By exploring the role of Keks and related proteins in fruit flies and other model systems, Duffy hopes to glean new knowledge that may, one day, have an impact on human health. "The fruit fly is an excellent model system to study basic biologic processes," Duffy said. "Then, as we understand how these proteins function in the fly, we can use that knowledge to help us explore similar processes in humans."


'/>"/>

Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fine-tuning lasers to destroy blood-borne diseases like AIDS
2. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
3. Boston College profs study oxidative stress subcellular to discover its role in diseases
4. Studying component parts of living cells with carbon nanotube cellular probes
5. Story ideas from Molecular & Cellular Proteomics
6. Anthrax cellular entry point uncovered
7. Genome of marine organism tells of humans unicellular ancestors
8. Researchers discover critical detail of cellular defense against genetic mistakes
9. LIAI researchers discover new cellular mechanism that will significantly advance vaccine development
10. Cellular self-eating promotes pancreatitis
11. A new cellular pathway linked to cancer is identified by NYU researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
(Date:7/11/2014)... the marginal division of the striatum is also ... impact degree of substance P in the striatal ... Yu and his team, College of Biophotonics, South ... that substance P receptor, neurokinin 1 was highly ... of normal rats. Unilateral or bilateral injection of ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... Women who are satisfied with everyday life and ... alcohol, reveals a thesis from the University of Gothenburg, ... thesis, has looked at how everyday life affects alcohol ... in Gothenburg (WAG) population study which has been ongoing ...
... immune system can affect healthy people,s personality traits as ... suicidal behaviour, reveals a thesis from the University of ... system and is responsible for defending humans against infection ... is therefore vital for our survival. Research has demonstrated ...
... The more allergies one has, the lower the risk ... published in Cancer Epidemiology, Biomarkers & Prevention , ... Researchers from the University of Illinois at Chicago, ... use for 419 patents with glioma and 612 cancer-free ...
Cached Biology News:Women involved in leisure activities drink less alcohol 2Genes of the immune system are associated with increased risk of mental illness 2Allergies lower risk of low- and high-grade glioma 2
(Date:7/10/2014)... 10, 2014 Deep Knowledge Ventures ... Forum on ‘Commercialising Longevity Research’ and welcomed a ... the London Bioscience Innovation Center for the event, ... Aging Analytics Ltd. The meeting highlighted the need ... research for age-related disease, as well as the ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Unraveling ... closer together. The Archer Family purchased a ... within DNA, but ended up with a lifetime of ... contained within the family members’ DNA genuinely brought the ... decided to search deeper into genetic history and prior ...
(Date:7/10/2014)... Montreal, QC (PRWEB) July 10, 2014 ... comfort and convenience. This rejuvenating device now comes with a ... that develops over time. , The new cup is thinner ... This design works to target rough, thin and uneven surfaces ... original firm cup for a stimulating treatment on areas such ...
(Date:7/10/2014)... 10, 2014 On July 9 ... , presented Russia,s first national ... The Company is developing a unique project called ... develops a number of innovative drugs based on monoclonal ... ceremony took place at the International Exhibition "Innoprom 2014" ...
Breaking Biology Technology:DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 2DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 3DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 4DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 5DKV Sponsors Forum on Commercialising Longevity Research; Brings Together Scientists, Investors, Entrepreneurs and Celebrities 6Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Dmitry Medvedev Presented BIOCAD the First National "Industry" Award 2
... Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced today that it ... enrolment in its U.S. Phase II trial to,evaluate ... sarcomas that have metastasized to the lung., ... full enrolment of 52,patients, Oncolytics had to demonstrate ...
... the gecko,s uncanny ability to climb sheer walls, researchers at ... is the first to master the easy attach and easy ... useful for a range of products, from climbing equipment to ... material is crafted from millions of tiny, hard, plastic fibers ...
... blueprint of all life, giving instruction and function to ... beings. Now Northwestern University researchers report they have used ... build a three-dimensional structure out of gold, a lifeless ... the researchers built two common but very different crystalline ...
Cached Biology Technology:Oncolytics Biotech Inc. Proceeds to Full Enrolment in U.S. Phase II Sarcoma Clinical Trial 2Oncolytics Biotech Inc. Proceeds to Full Enrolment in U.S. Phase II Sarcoma Clinical Trial 3The pitter patter of little feet ... climbing straight up a wall 2DNA is blueprint, contractor and construction worker for new structures 2DNA is blueprint, contractor and construction worker for new structures 3
Hepatocyte Differentiation Environment...
...
High voltage electrophoresis power supply...
... Major Science Major Science MS 300V (Cat. ... supply designed to meet most electrophoresis needs ... unit. Major Science MS 300V power supply ... to instruments used in electrophoresis. 4 pairs ...
Biology Products: