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Tuning in on cellular communication in the fruit fly
Date:2/18/2009

s team found that when they disrupted the Kek5 protein in developing fruit flies their wings would not grow properly. Conversely, when Duffy's team engineered fruit fly cells to have too many copies of Kek5, the wings grew with defects. "It was pretty clear that Kek5 was regulating the BMP pathway, and that was an exciting observation," Duffy said.

The recent work on Kek5 follows earlier studies in the Duffy lab that revealed a related protein, Kek1, regulates the Epidermal Growth Factor (EGF) pathway, which is another important developmental pathway. Problems with the BMP and EGF pathways are implicated in cancer, bone disorders, heart disease, and neurodegenerative diseases. Developing compounds that can regulate or repair these pathways is an active area of therapeutic research.

By exploring the role of Keks and related proteins in fruit flies and other model systems, Duffy hopes to glean new knowledge that may, one day, have an impact on human health. "The fruit fly is an excellent model system to study basic biologic processes," Duffy said. "Then, as we understand how these proteins function in the fly, we can use that knowledge to help us explore similar processes in humans."


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Contact: Michael Cohen
mcohen@wpi.edu
508-868-4778
Worcester Polytechnic Institute
Source:Eurekalert

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