Navigation Links
Tumors evolve rapidly in a childhood cancer, leaving fewer obvious tumor targets
Date:1/20/2013

s of individual patients with neuroblastoma, detect their specific cancer-causing mutations, and then select from a menu of treatments," said Maris. The oncology researchers designed the TARGET study to perform genomic analyses of a large cohort of high-risk neuroblastoma patients, with the goal of mapping out a limited number of treatment strategies. This approach would represent a significant step forward in personalizing neuroblastoma therapy.

However, while the researchers confirmed that roughly 10 percent of the study's neuroblastoma patients had ALK mutations, and found that a handful of other gene mutations each accounted for percentages in the single digits, there were relatively few recurrent mutations in somatic (non-germline) cells. "The relative paucity of recurrent mutations challenges the concept that druggable targets can be defined in each patient by DNA sequencing alone," wrote the authors.

In the absence of frequently altered oncogenes that drive high-risk neuroblastomas, the authors concluded that most such cases may result from other changes: rare germline mutations, copy number variations and epigenetic modifications during tumor evolution.

"Personalized medicine is more complex than we had hoped," said Maris. "While there are successes such as those in treating patients whose tumors harbor ALK mutations, this study implies that we must think very differently about how we'll use genomics to define treatment." Maris added that neuroblastoma researchers may need to turn to functional genomics, learning which tumors will or won't respond to treatments, as well as going beyond a static picture of a cancer cell with fixed genetic contents, to devising interventions to deal with dynamic tumor cells that evolve during nervous system development.


'/>"/>
Contact: Rachel Salis-Silverman
salis@email.chop.edu
267-426-6063
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2

Related biology news :

1. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
2. TGen leads new National Institutes of Health study of brain tumors
3. A single stem cell mutation triggers fibroid tumors
4. Cancerous tumors deliver pro-metastatic information in secreted vesicles
5. Breast cancer drug could halt other tumors
6. Researchers identify proteins that indicate which kidney tumors are most likely to spread
7. Cancer stem cells isolated from kidney tumors
8. Study uncovers mechanism used by BRCA1 to suppress tumors
9. Leading evolutionary scientist to discuss how genome of bacteria has evolved
10. Excessive worrying may have co-evolved with intelligence
11. Hitting snooze on the molecular clock: Rabies evolves slower in hibernating bats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , July 2, 2015 Fingerprint Cards ... FPC1035, FPC1145 and FPC1155 from the distributor World Peace Industrial ... FPC,s distributors in Asia . Deliveries are ... sensors will be used by smartphone manufacturers in ... included in the communicated revenue guidance of approximately 2,200 MSEK ...
(Date:6/30/2015)... , June 30, 2015 To bolster its efforts ... HYPR Corp. announced today the addition of two new team ... as board advisor and David Raviv will act ... underscore HYPR Corp.,s commitment to providing the most secure solutions ... Sirota co-founded Layer 7 Technologies, a provider of security ...
(Date:6/30/2015)... HATFIELD, Pa. , June 30, 2015 ... joined the company as CEO to help further develop ... a wealth of partnering experience, having spent much of ... companies including Therakine, Amgen, Baxter Bioscience, and Johnson & ... a focus on Technology and Biotech Corporate Finance. He ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3Genisphere Appoints New CEO, Thomas Bliss 2Genisphere Appoints New CEO, Thomas Bliss 3
... new study led by researchers at Columbia University Medical Center ... points to existing drugs which may be able to slow ... known as polyamines that were found to be responsible ... neurons, which causes the neurons to malfunction and, eventually, die. ...
... The Society for Nutrition Education (SNE) honored several members ... Conference in Reno, Nevada, July 24 27, 2010. ... excellence in nutrition education. The Helen Denning Ullrich ... Award of Excellence is given each year to an SNE ...
... graduate of the School of Chemical Engineering and Analytical Science, ... was announced at the Science, Engineering and Technology Awards in ... September 3rd. The SET Awards are Europe,s most important ... award for his final year design project detailed design ...
Cached Biology News:New pathway identified in Parkinson's through brain imaging 2New pathway identified in Parkinson's through brain imaging 3New pathway identified in Parkinson's through brain imaging 4The Society for Nutrition Education honors nutrition educators 2Dyfan is Chemical Engineering Student of the Year 2
(Date:7/2/2015)... ALTO, Calif. (PRWEB) , ... July 02, 2015 , ... ... to improve an individual’s quality of sleep, launched its Indiegogo campaign on June 23. ... functionality: Luzi's voice command technology makes it effortless to use, while the integration of ...
(Date:7/2/2015)... ... July 02, 2015 , ... In’Tech Medical SAS ( ... Orthopedics, announced today the acquisition of Turner Medical, Inc ., thus becoming ... instruments to the Spine Industry. The acquisition of Turner Medical ideally supplements In’Tech ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to separate ... single photon emission computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, ... 20,000 brain scans and is believed to be the largest brain imaging study ever, ...
(Date:7/1/2015)... N.C. and PARIS ... firm AgBiome, and Genective, key developer of biotech ... the discovery of new generations of insect control ... insect control to counter the realities of advancing ... Genective, aligning AgBiome,s unique insect control technology with ...
Breaking Biology Technology:Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4AgBiome and Genective collaborate to create novel insect-resistant crops 2
... 3 Sangamo BioSciences,Inc. (Nasdaq: SGMO ) announced ... will provide an update on the progress of,Sangamo,s ZFP ... strategy at 12:45pm (PT) on Wednesday, October 10, 2007,at ... will be webcast live and may be accessed via ...
... Cadence Pharmaceuticals,Inc. (Nasdaq: CADX ), a biopharmaceutical ... candidates principally,for use in the hospital setting, announced ... will present the corporate overview on,Wednesday, October 10, ... Eastern Time),during the BIO Investor Forum in San ...
... Laboratories to 45%, GURGAON, India, Oct. 3 ... announced the,signing of Definitive Agreements, providing for an increase ... 45% at a price of Rs. 160 per share,aggregating ... of shares from the existing Promoters (b) Preferential ...
Cached Biology Technology:Sangamo BioSciences to Present at the 2007 BIO InvestorForum 2Cadence Pharmaceuticals' CEO Theodore Schroeder to Present at BIO Investor Forum 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 2Ranbaxy to Consolidate Position in Biopharmaceuticals and Speciality Injectables Including Oncology 3
... is an exciting product for cell-based kinetic ... required the use of expensive HTS equipment, ... in the assay development stage. The NOVOstar ... assays as well as any other assay ...
... The Digital Clamp One can operate as a ... a Conductance (Dynamic) Clamp in electrophysiology research applications. ... as conventional analog equipment. • ... very recent advances in the capabilities of Digital ...
... These handy dispensers save space ... wipers, hats, and other garb. ... storage bins for small parts ... manufacturing. Clear acrylic. Many other ...
... Security ChemStation is a ... application for data acquisition, ... searching and reporting, addressing ... data security, integrity, and ...
Biology Products: