Navigation Links
Tumor suppressor gene in flies may provide insights for human brain tumors
Date:6/22/2009

SINGAPORE and DURHAM, N.C. In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor.

Researchers at Duke-NUS Graduate Medical School in Singapore have found a tumor-suppressing protein in the fly's brain, with a counterpart in mammals, that can apparently prevent brain tumors from forming.

"Our data explicitly show that the fruitfly protein PP2A (protein phosphatase 2A) suppresses brain tumor formation and controls the balance of self-renewal and differentiation of neural stem cells," said Hongyan Wang, Ph.D, assistant professor of neuroscience and behavioral disorders, and senior author of a paper published online in the journal Development.

"Given that mechanisms for stem cell division in flies and mammals are likely to be similar, our study on fly PP2A may provide useful insights for certain types of human brain tumors and possibly in a wide variety of cancers," Wang said.

By studying flies that had a PP2A mutation, the researchers learned that flies with missing or abnormally expressed PP2A had ten times the amount of stem cell growth in their larval brains. The flies' neural stem cells did not become neurons (nerve cells) in the brain, the types of cells needed for normal function. Instead, they effectively grew into a tumor mass.

Dr. Wang's previous work had identified a protein kinase called Polo as a tumor suppressor. Because phosphatases like PP2A usually have the opposite biochemical function to kinase, the scientists predicted that PP2A would stop the tumor suppressor Polo and allow for unchecked cell growth. "We were very surprised when we found that PP2A also suppressed tumors," Wang said.

Follow-up experiments showed that PP2A is important for regulating Polo kinase function, and showed that these two critical brain tumor suppressors work together to control neural stem cell divisions.

"Our discovery suggests that PP2A and Polo, both of which are crucial brain tumor-suppressors and cell cycle regulators, can function in the same pathway to regulate stem cell self-renewal and tumor development," Wang said. The research team plans to uncover novel proteins in this pathway by learning which protein functions between PP2A and Polo during the neural stem cell division process.


'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Related biology news :

1. Invasion of the brain tumors
2. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
3. Bits of junk RNA aid master tumor-suppressor gene
4. Analysis of breast and colon cancer genes finds many areas of differences between tumors
5. Tumor genome analysis unveils new insights into lung cancer
6. Cell response to stress signals predicts tumors in women with common pre-breast cancer
7. Synthetic compound promotes death of lung-cancer cells, tumors
8. MIT: Remote-control nanoparticles deliver drugs directly into tumors
9. New X-ray technique targets terrorists and tumors
10. DNA methylation shown to promote development of colon tumors
11. Gene variation may elevate risk of liver tumor in patients with cirrhosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... 2, 2016 The Department of Transport ... the 44 million US Dollar project, for the , ... including Personalization, Enrolment, and IT Infrastructure , to ... production and implementation of Identity Management Solutions. Numerous renowned international ... Decatur was selected for the most compliant ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... subsidiary of Infosys (NYSE: INFY ), and Samsung ... global partnership that will provide end customers with a ... and payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ... for financial services, but it also plays a fundamental part ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf K. Hoffmann, former ... of the University of North Carolina Kenan-Flagler Business School effective June ... UNC Kenan-Flagler, with a focus on the school’s international efforts, leading classes and ...
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... Wausau, WI (PRWEB) , ... June 23, 2016 ... ... probiotic supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, ... supplements for over 35 years, is proud to add Target to its list ...
(Date:6/23/2016)... , June 23, 2016 Houston ... with the Cy-Fair Sports Association to serve as ... the agreement, Houston Methodist Willowbrook will provide sponsorship ... and connectivity with association coaches, volunteers, athletes and ... with the Cy-Fair Sports Association and to bring ...
Breaking Biology Technology: