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Tumor microenvironment helps skin cancer cells resist drug treatment
Date:7/4/2012

a targeted therapy available, it puts you on good footing to narrow in on specific factors that may be at play in drug resistance."

Several HGF/MET inhibitors are in clinical development or are FDA-approved for other indications, making clinical trials combining these inhibitors with BRAF inhibitors feasible in the future. In addition, researchers could follow the same approach taken by the team to screen other drugs currently in development, identifying mechanisms of resistance and ways to counter them even before treatment begins.

"Drug resistance should no longer surprise us," said Golub. "We're thinking about how to do this how to systematically dissect resistance much earlier in the drug development process so that by the time a new drug enters the clinic, we have a good sense of what the likely mechanisms of resistance will be and have a strategy to combat them."


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Contact: Haley Bridger
hbridger@broadinstitute.org
617-714-7968
Broad Institute of MIT and Harvard
Source:Eurekalert

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