Navigation Links
Tumor-inhibiting protein could be effective in treating leukemia
Date:7/14/2008

Angiocidin, a tumor-inhibiting novel protein discovered by Temple University researchers, may also have a role as a new therapeutic application in treating leukemia, according to a study by the researchers.

The study, "The Novel Angiogenic Inhibitor, Angiocidin, Induces Differentiation of Monocytes to Macropahges," will be published in the July 15 issue of the journal Cancer Research (http://cancerres.aacrjournals.org/future/68.14.shtml). The research was done by Temple biology doctoral student Anita Gaurnier-Hausser under the direction of George Tuszynski, a professor of neuroscience in Temple's School of Medicine and a professor of biology in Temple's College of Science and Technology.

"Angiocidin is a protein that has a lot of anti-cancer activity and inhibits angiogenesis, a physiological process involving the growth of new blood vessels from pre-existing vessels, which is a fundamental step in the transition of tumors from a dormant state to a malignant state," said Tuszynski, who discovered the protein.

Tuszynski said that over the years, the researchers had looked at the protein's effect on solid tumors like breast cancer, prostate cancer and colon cancer.

"All of these cancers are inhibited by Angiocidin by virtue of the fact that this protein inhibits vascularization or the formation of new vessels," he said. "We decided we wanted to look to see if Angiocidin had any effect on hematologic malignancy, and we chose leukemia."

Tuszynski said leukemia cells arise from monocytes, a specific white blood cell that is a part of the human body's immune system that protects against bloodborne pathogens and moves quickly to sites of infection. As monocytes enter tissue, they undergo a series of changes to become macrophages.

When the researchers treated the leukemia cells, "our molecule was able to induce a differentiation of these mono
'/>"/>

Contact: Preston M. Moretz
pmoretz@temple.edu
215-204-4380
Temple University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wasps and bumble bees heat up, fly faster with protein-rich food
2. Protein marker for schizophrenia risk
3. Scientists reveal the key mechanisms for affinity between transient binding proteins
4. Small protein may have big role in making more bone and less fat
5. A mammalian clock protein responds directly to light
6. Scientists find potential protein biomarkers for growth hormone
7. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
8. Researchers reveal insights into hidden world of protein folding
9. Mechanism explains link between apolipoprotein E and Alzheimers disease
10. A protein sequence associated with Huntington’s disease may become life-saving vaccine component
11. Fruit fly helps identify protein critical to eggshell formation that may be pesticide target
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... planet,s current biodiversity, the product of 3.5 billion years ... the history of life. But it may be reaching ... scientific literature and analysis of data published in ... the loss and decline of animals is contributing to ... planet,s sixth mass biological extinction event. , Since 1500, ...
(Date:7/24/2014)... MADISON A multi-institutional team of researchers has developed ... tract. This safe, noninvasive method for assessing the function ... could lead to better diagnosis and treatment of gut ... bacterial overgrowth, irritable bowel syndrome and inflammatory bowel disease ... serious side effects in patients with diseases such as ...
(Date:7/24/2014)... counterparts in humans, affect the connections between nerve cells ... hippocampus, an area of the brain that plays a ... memories. The results of the study have been published ... depends on the active communication between nerve cells, known ... into a dense network where they constantly relay signals ...
Breaking Biology News(10 mins):Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3New imaging agent provides better picture of the gut 2A protein couple controls flow of information into the brain's memory center 2A protein couple controls flow of information into the brain's memory center 3A protein couple controls flow of information into the brain's memory center 4
... passed on from mother to child is decided very early ... ovary. In a cell division process that is unique to ... egg before it is fertilised. Using a powerful microscope, researchers ... how the molecular machinery functions that is responsible for chromosome ...
... long-held belief that plant-eating insects in tropical forests are ... dining only on locale-specific vegetation is being challenged ... on a broader menu of foliage and can be ... These findings have significant implications related to ...
... just whats in your genes, its how you turn them on ... yeast according to a report by Yale researchers in this ... the protein coding genes of humans and chimpanzees are about 99 ... Cullman Professor of Molecular Cellular and Developmental Biology at ...
Cached Biology News:A unique arrangement for egg cell division 2Tropical insects 'go the distance' to inform rainforest conservation 2Evolution is driven by gene regulation 2
(Date:7/25/2014)... 25, 2014 At the request of ... a 60-day extension for the public comment period (Docket ... for Model Aircraft established by Congress as part of ... 60-day extension establishes the new deadline for comments as ... of Transportation/FAA notice published in the Federal Register on ...
(Date:7/24/2014)... Calif. , July 24, 2014  Now available ... to home. Rehealth Regenerative Therapies , located in ... and other physically active people a new health option: ... Regardless of age, countless patients suffer from joint ... activities, such as muscle tears, torn rotator cuff, tennis ...
(Date:7/24/2014)... to materialise. Yet, scientists are making progress in ... One such approach relies on quantum dotsa kind ... electric field. A new study demonstrates that changing ... (TQDs) with electrical impulses can help better control ... be used as quantum information units, which would ...
(Date:7/24/2014)... Your cell phone may stay charged ... storage capacity. , New research indicates that lithium-ion ... at Lawrence Livermore National Laboratory and ... components will perform as electrodes. , The growing ... for higher-performance batteries. Several key characteristics of lithium-ion ...
Breaking Biology Technology:FAA Grants Comment Extension at the Request of AMA 2Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Getting More Life out of Lithium-ion Batteries 2
... GenVault,s energy and space efficient technologies ideally suit ... create a new paradigm for eco-friendly, sustainable Biobanking ... announces the opening of its newly-formed Japanese subsidiary ... the expanding Biobanking market and its growing customer ...
... Therapeutics, Inc., a privately held ophthalmic-focused biopharmaceutical company, today ... ophthalmic gel, 0.15%, has been accepted for review by ... is seeking approval for ganciclovir as a treatment for ... simplex virus. The FDA has issued an action date ...
... 26 Fifty percent of clinical trial management ... share high-value, proprietary company information via e-mail, while ... overnight courier (14 percent), according to a recent ... for exchanging clinical trial information with outside parties ...
Cached Biology Technology:GenVault Opens Japanese Subsidiary to Better Address Global Biobanking Market Growth 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 2Sirion Therapeutics New Drug Application for Ganciclovir is Accepted for Review by the FDA for the Treatment of Ocular Herpes 3IntraLinks Poll: Half of Clinical Trial Management Professionals Share Critical Information Via E-Mail 2
... General description: Humidity wells in the base ... chamber humidity and probe hydration around the ... eliminates the risk of waterbath contamination. This ... temperature waterbaths or hybridisation ovens. Linkage: This ...
... Protein DetectorTM Microarray Dot Blot Kits ... accuracy and quantitation over a wide range ... formats ) detection. They are ideal ... profiling hundreds of samples for the presence ...
... Slide features an ultra-thin nitrocellulose coating ... the first protein microarray slide to ... in a thin film with low,background ... ,The PATH™ Slide can be used ...
... Stabilizer is an aqueous solution that ... other non-toxic stabilizing chemicals in a ... 6.5. This product contains ... 0.02% bromonitrodioxane as a preservative. ...
Biology Products: