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Tumor blood vessels prevent the spread of cancer cells
Date:2/11/2013

rly closely since their vascular barrier against metastatic spread might be defective.

"At the same time, we also show that tumours that have developed in mice lacking the endoglin gene are considerably more sensitive to treatment with a certain kind of antiangiogenic drugs that target the growth factor VEGF," says Professor Pietras. "HHT patients with cancer may therefore benefit greatly from the VEGF blockers currently in clinical use."

"Going by the results of our study, we also suggest, paradoxically, that a combination of drugs that block endoglin and VEGF should be tried as an effective cancer therapy; a solution thatis already being tested in clinical studies in the USA," he adds.


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