Navigation Links
Tumor blood vessels prevent the spread of cancer cells
Date:2/11/2013

A lack of the protein endoglin in the blood vessels of tumour-bearing mice enables the spread of daughter tumours, according to researchers at Karolinska Institutet and Lund University in Sweden in a study published in the scientific periodical The Journal of Experimental Medicine. Given that the tumour vasculature constitutes an important barrier to the spread of cancer cells, the team suggests that drugs should be developed to strengthen the blood vessels' protective function.

Studies of the process of metastasis (the spread of daughter tumours) have mainly focused on how the properties of the cancer cells themselves promote their spread. For the present study, however, the researchers studied the function of a specific signal pathway consisting of the protein endoglin in the vasculature of tumour-bearing mice. They discovered that when the gene that codes for endoglin was missing in the blood vessels in tumours in the breast, lung or pancreas, it led to increased metastatic spread to other organs.

"The study shows that the blood vessels play an important role in preventing the spread of tumour cells through the blood stream," says Kristian Pietras, professor at Lund University and also affiliated to Karolinska Institutet. "This is because blood vessels lacking in endoglin change in a way that makes it easier for the cancer cells to enter the blood stream and spread to other organs. So with this in mind, we suggest that drugs should be developed to strengthen the barrier function of the blood vessels to prevent the spread of cancer."

The results of the study are also of significance to patients with the rare congenital syndrome Hereditary Hemorrhagic Telangiectasia (HHT), which in some patients is caused by the lack of onecopy of the endoglin gene. HHT causes deformities of the blood capillaries and increases the risk of haemorrhage. The researchers believe that HHT patients afflicted by cancer should be monitored particularly closely since their vascular barrier against metastatic spread might be defective.

"At the same time, we also show that tumours that have developed in mice lacking the endoglin gene are considerably more sensitive to treatment with a certain kind of antiangiogenic drugs that target the growth factor VEGF," says Professor Pietras. "HHT patients with cancer may therefore benefit greatly from the VEGF blockers currently in clinical use."

"Going by the results of our study, we also suggest, paradoxically, that a combination of drugs that block endoglin and VEGF should be tried as an effective cancer therapy; a solution thatis already being tested in clinical studies in the USA," he adds.


'/>"/>

Contact: Karolinska Institutet Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Related biology news :

1. The loss of a protein makes jump the tumor to the lymph node
2. Nanotherapy: Treating deadly brain tumors by delivering big radiation with tiny tools
3. Dental X-rays linked to common brain tumor
4. TGen leads new National Institutes of Health study of brain tumors
5. Immune-response genes affecting breast tumor eradication
6. A single stem cell mutation triggers fibroid tumors
7. Clusters of cooperating tumor-suppressor genes are found in large regions deleted in common cancers
8. Cancerous tumors deliver pro-metastatic information in secreted vesicles
9. Researchers identify need to sample multiple tumor zones in breast cancer
10. Tumor microenvironment helps skin cancer cells resist drug treatment
11. BGI debuts new tool PDXomics for tumor xenograft research and applications
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2016)... This BCC Research report provides an overview ... Sequencing (RNA Seq) market for the years 2015, 2016 ... reagents, data analysis, and services. Use this ... market such as RNA-Sequencing tools and reagents, RNA-Sequencing data ... each segment and forecast their market growth, future trends ...
(Date:3/3/2016)... 3, 2016  FlexTech, a SEMI Strategic Association Partner, ... Research & Development, Leadership in Education, and, in a ... 9 th year of the FLEXI Awards and ... individuals from past years . Judging was done ... set of criteria, by a panel of non-affiliated, independent, ...
(Date:3/2/2016)... 2016 http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) ... "Global Biometrics as a Service Market 2016-2020" ... --> http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced the ... a Service Market 2016-2020" report to ... and Markets ( http://www.researchandmarkets.com/research/cmt3hk/global_biometrics ) has announced ...
Breaking Biology News(10 mins):
(Date:4/26/2016)... ... 26, 2016 , ... BaseHealth , the comprehensive predictive ... as Chief Business Officer. Arianpour, a genomics pioneer and visionary commercial leader with ... recently Chief Commercial Officer of Pathway Genomics. He has held senior executive roles ...
(Date:4/26/2016)... ... , ... This unique "Fertility Happy Hour" event will be held at The ... the lowdown on female fertility and the reproductive technologies that are empowering a new ... IVF - The Arizona Center, will give a short presentation and answer questions ...
(Date:4/26/2016)... , ... April 26, 2016 , ... uBiome, the leading ... new position on the company’s Advisory Board. Prior to co-founding Plum in 2007, Neil ... Senior Designer at IDEO. , A renowned, innovative designer of ideas, products, and brands, ...
(Date:4/26/2016)... ... 2016 , ... Global Stem Cells Group has announced that affiliate ... the keynote speaker at the Asia-Pacific Symposium in Santiago Chile, July 1-2, 2016. The ... regenerative medicine is increasingly being understood to be effected through paracrine factors. Central to ...
Breaking Biology Technology: