Navigation Links
Tulane receives grant to study limb regeneration

Could the salamander's natural ability to grow back severed appendages lead to a scientific breakthrough for humans who have lost limbs?

With the help of a $6.25 million U.S. Department of Defense grant, Tulane University professor Ken Muneoka, the John L. and Mary Wright Ebaugh chair in science and engineering, will lead a team of researchers from the University of California - Irvine and the University of Kentucky to identify the genes that trigger regeneration in the axolotl, a Mexican salamander.

The researchers will then attempt to determine how the same genes are regulated in response to injuries in mice who, because of their similar genetic characteristics, serve as a model for humans.

"The hope is that once the genetic signals for regeneration are identified, therapies can be developed to enhance the regenerative response in humans," Muneoka says.

Regeneration of tissue in humans is a long-term goal of Muneoka who, like his colleagues, has conducted research in this area for many decades.

The shorter term goal is to modify the body's natural healing process to transition from a scar-forming response to the initiation of a regenerative response. Muneoka says this might involve cell-based therapies with regeneration-promoting cells, and/or factor-based therapies, such as providing a specific growth factor, to initiate and/or sustain the regenerative response.

While the salamander is the only animal capable of regenerating lost appendages, a child can grow back the tip of a severed finger, and, even in adults, bone, muscle, cartilage and skin can independently undergo a healing and regeneration response.

"What's missing is a way to coordinate these events so complex structures can be restored," Muneoka says. "By establishing a comprehensive database that identifies all the genes involved in regenerating a salamander limb, we will essentially create a genetic blueprint of how to do the same in humans."

The grant that will fund Muneoka and his colleagues' research is the result of a competition the Army Research Office, the Office of Naval Research and the Air Force Office of Scientific Research conducted under the Department of Defense's Multidisciplinary University Research Initiative (MURI) program.

Through the competition 69 academic institutions were awarded $260 million over the next five years to perform multidisciplinary basic research.


Contact: Mike Strecker
Tulane University

Related biology news :

1. Springer Series editor John Smol receives two prestigious biology awards
2. URI receives $18 million grant to strengthen biomedical research capacity in Rhode Island
3. Vitamin D expert receives Linus Pauling Prize for Health Research
4. UC Riverside geneticist receives highest honor from Botanical Society of America
5. WPI professor receives Fulbright Scholarship to work on tissue engineering in Ireland
6. UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants
7. Lyncean Technologies Inc. receives $1.2 M from NCRR to develop new imaging technique
8. UAB professor receives HudsonAlpha Innovation Prize
9. George M. Whitesides receives inaugural Dreyfus prize in the chemical sciences
10. SRI International receives $100,000 Grand Challenges Explorations grant
11. Georgetown Universitys Howard J. Federoff, M.D., Ph.D. receives Bernard Sanberg Memorial Award
Post Your Comments:
(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - ...
(Date:6/15/2016)... 15, 2016 Transparency Market ... Recognition Market by Application Market - Global Industry Analysis Size ... to the report, the  global gesture recognition market ... and is estimated to grow at a CAGR ... 2024.  Increasing application of gesture recognition ...
(Date:6/3/2016)... 3, 2016 Das ... Nepal hat ein 44 ... geprägter Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, ... Produktion und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte ... Januar teilgenommen, aber Decatur wurde als konformste ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... June 24, 2016 Epic Sciences unveiled ... cancers susceptible to PARP inhibitors by targeting homologous ... (CTCs). The new test has already been incorporated ... multiple cancer types. Over 230 clinical ... response pathways, including PARP, ATM, ATR, DNA-PK and ...
(Date:6/23/2016)... WI (PRWEB) , ... June 23, 2016 , ... ... supplements, is pleased to announce the launch of their brand, UP4™ Probiotics, into ... for over 35 years, is proud to add Target to its list of ...
(Date:6/23/2016)... HOUSTON , June 23, 2016 ... agreement with the Cy-Fair Sports Association to serve ... of the agreement, Houston Methodist Willowbrook will provide ... education and connectivity with association coaches, volunteers, athletes ... partner with the Cy-Fair Sports Association and to ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: