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Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
Date:5/11/2010

iology and director of the Tufts Center for Regenerative and Developmental Biology. Tufts' emphasis on cross-disciplinary work was an important factor in Levin's decision to come to Tufts last year.

"We also expect the cluster to intensify collaboration with math and computer science faculty and with researchers from such external organizations as Harvard Medical School and the National Institutes of Health," said Juliet Fuhrman, Ph.D., chair of biology.

Over the next two years, Tufts will redesign office and laboratory space at 200 Boston Avenue into 16,527 square feet of wet laboratories and associated support facilities. The new space will be designed to LEED Gold certification standards.

Cummings Foundation, Inc., a private operating foundation based in Woburn, Massachusetts, owns the property at 200 Boston Avenue.

Tufts University biologists have been at the forefront of understanding the roles of both genome instability and dysregulation of normal development in human disease. They are credited with uncovering the first multistranded DNA structure (triplex H-DNA), discovering that the anomalous replication of DNA microsatellites is a common source of genome instability, and unraveling molecular mechanisms of chromosome fragility. In developmental biology, they are credited with several revolutionary approaches for the rational control of large scale patterning in eye, heart, and kidney development; limb induction; spinal cord/muscle regeneration; left right asymmetry; craniofacial patterning and nervous system development. They have made key contributions toward understanding the molecular mechanisms underlying the biophysical multi-scale patterning control systems that guide embryonic development, regenerative repair and prevention of cancer.

Current collaborations include studies in model systems of diseases like fragile X mental retardation and Huntington's and Friedreich's ataxia, as well as the molecula
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Contact: Kim Thurler
kim.thurler@tufts.edu
617-627-3175
Tufts University
Source:Eurekalert

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