Navigation Links
Tufts University researcher develops living tissue
Date:11/8/2011

MEDFORD/SOMERVILLE, Mass. A new approach to studying tissue development has earned Catherine K. Kuo, Ph.D., an assistant professor of biomedical engineering in Tufts University's School of Engineering, the Basil O'Connor Starter Scholar Award from the March of Dimes Foundation.

Kuo's research could yield insight into factors that contribute to orthopedic birth defects that occur in utero, such as clubfoot, which requires multiple surgeries to enable normal standing and walking. These defects occur as a result of abnormal musculoskeletal tissue development of the embryo.

In her experiments, Kuo will use living engineered embryonic tendon tissue to see how muscle movement by the developing fetus -- for example, kicking -- might influence abnormal musculoskeletal tissue development in the embryo.

"Currently we don't know the extent to which muscle activity contributes to birth defects," says Kuo. "I chose the tendon as a model tissue to study because of its critical roles in force transmission and joint stabilization in a normal musculoskeletal system."

Kuo will engineer tendon tissue in the lab from cells from chick and mouse embryos. "It's very difficult to study developing tissue, in this case, tendon, inside the body, and especially in utero," she says.

Kuo will seed living embryonic cells into a porous, biodegradable synthetic scaffold. Placed into a nutrient-rich bioreactor, the cell-seeded scaffold will grow into living engineered tissue.

Kuo will subject the tissue-engineered tendon to forces that mimic muscle movement, such as flexing, which occurs during kicking. Using this approach, Kuo will study what happens when cells are forming into tendons while being constantly exposed to stretching, twisting, and other forces.

"At the end of the day, we want to have the answers to the questions: How does tissue stiffness affect the developing cells? How does movement such as kicking affect them? And what are
'/>"/>

Contact: Alex Reid
alexander.reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Tufts graduate students receive $10,000 prizes
2. Tufts biomedical engineer Fiorenzo Omenetto named Guggenheim Fellow
3. Tufts engineering professor wins NSF Career Award
4. Tufts professor earns ISCB Award for Excellence in Chemical Sciences
5. Tufts announces public launch of the Tufts Institute for Biomedical Partnerships website/HUB
6. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
7. Tufts University chemist earns prestigious award for promising research on drug development
8. Tufts graduate students win $10,000 prizes
9. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
10. Tufts students host Earth Day with groundbreaking ceremony for solar house
11. Tufts University professor receives IADR Pharmacology/Therapeutics/Toxicology Award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Tufts University researcher develops living tissue
(Date:10/16/2014)... , October 16, 2014 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... leading edge technologies including Wocket™, the Smart Wallet, at ... Conferenece. FiRe is a leading global conference on the ... Hosted by Mark Anderson , founder and publisher ...
(Date:10/15/2014)... to an unexpected extent. The outbreak does not follow ... shows a new disease dynamic in regions, where it ... German National Academy of Sciences Leopoldina, acatech – the ... of the German Academies of Sciences and Humanities have ... In the statement the academies call for the following ...
(Date:10/14/2014)... prostate cancer tumors scavenge and hoard copper that is ... may be a fatal weakness. , Researchers at ... cancer cells by delivering a trove of copper along ... brimming with the mineral, leaving non-cancer cells healthy. , ... available for other uses, could soon be tested in ...
Breaking Biology News(10 mins):NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Prostate cancer's penchant for copper may be a fatal flaw 2
... characterise their Zap-It! product, which uses the tiny electric ... itching caused by insect bites - such as those from ... that is based around a similar piezoelectric mechanism to that ... a medical device, currently available to buy in high street ...
... Molecular biologist Ichiro Matsumoto, Ph.D., of the Monell Center, ... Young Investigators in Gustation, awarded annually by the Association ... who is an emerging leader in the field of ... the understanding of the organization, relationships and connectivity of ...
... of the potentially deadly antibiotic-resistant bacterium known as MRSA ... a new study involving two Northern Arizona University researchers., ... for Microbial Genetics and Genomics, and Lance Price, NAU ... Microbiology and Environmental Health at the Translational Genomics Research ...
Cached Biology News:Zapping mosquito bites 2Evolution of staph 'superbug' traced between humans and food animals 2
(Date:10/22/2014)... Shimadzu Scientific Instruments introduces its Open Solution QuantAnalytics(TM) ... management and clinical markets. The software increases the speed ... users to highlight and review results that are of ... to filter results by group or based on a ... need to sift through analytes of no interest. In ...
(Date:10/22/2014)... UAE (PRWEB) October 22, 2014 Grace ... science and healthcare projects, announces the addition of ... DCH to its advisory team. Dr. Siddiqui will provide ... , A graduate of University College Medical ... subsequently degreed in medicine in 2001. With further certification ...
(Date:10/22/2014)... , Oct. 22, 2014 /PRNewswire/ - iCo Therapeutics ("iCo" ... announced next steps for its Oral Amphotericin B ... its in vitro work involving samples ... now plans to complete pre clinical studies and ... Phase 1A clinical trial, utilizing approximately $700,000 of ...
(Date:10/20/2014)... The report “Pharmacy Automation Systems Market ... Labeling Systems, Table-top Counters) by End-user (Inpatient Pharmacy ... Trends to 2019” analyzes and studies the major ... Europe, Asia-Pacific, and the Rest of the World ... figures spread through 300 pages and in-depth TOC ...
Breaking Biology Technology:Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2Dr. Yousef Siddiqui joins the Grace Century Advisory Team 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 2iCo Therapeutics Announces Advancement of Oral Amphotericin B Program 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 2Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 3Pharmacy Automation Systems Market worth $4,566.2 Million by 2019 - New Research Report by MarketsandMarkets 4
... ... Intellectual Property, FULLERTON, Calif., Nov. 28 Beckman Coulter,Inc. ... and,automate complex biomedical testing announced today that it has entered,into an ... spin out of Lumigen, Inc., effected prior to Beckman,Coulter,s acquisition of ...
... Cambridge Research &,Instrumentation (CRi) announced today that ... of allowance for their patent application number,10/669,101, for ... patent covers the use of multispectral imaging combined,with ... of,fluorophores in a living mammal. The unmixing of ...
... 1-41 has significant ... and anti-amnesic benefits, GENEVA, Nov. 28 /PRNewswire-FirstCall/ - ... announce promising developments with,ANAVEX 1-41, the company,s lead drug ... 1-41 prevented oxidative stress,which damages and destroys cells and ...
Cached Biology Technology:Beckman Coulter to Acquire Exclusive Rights to Break-Through Technologies 2US Patent and Trademark Office Allows CRi's Patent Application for Spectral Imaging of Deep Tissue 2Anavex advances drug candidate for treatment of Alzheimer's disease 2Anavex advances drug candidate for treatment of Alzheimer's disease 3Anavex advances drug candidate for treatment of Alzheimer's disease 4Anavex advances drug candidate for treatment of Alzheimer's disease 5
...
...
Immunogen: Peptide corresponding to amino acid residues from the N-terminal region of human thyroid hormone receptor, alpha1/alpha2-isotype. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Antibodies were affinity purified using epitopes specific to QKI immobilized on solid support....
Biology Products: