Navigation Links
Tufts University chemist earns prestigious award for promising research on drug development
Date:11/12/2010

MEDFORD/SOMERVILE, Mass. Joshua Kritzer, assistant professor in the School of Arts and Sciences Department of Chemistry at Tufts University, has been awarded one of 33 NIH Director's New Innovator Awards, one of the most prestigious grants awarded by the National Institutes of Health.

The NIH Director's New Innovator Award program is designed specifically to support unusually creative new investigators with highly innovative research ideas at an early stage of their career. Awards recognize the potential of projects to have a significant impact on important biomedical or behavioral research problems.

The $1.5 million grant will fund Kritzer's research into a rapid drug-screening process that may help scientists identify new drugs to treat diseases. Scientists today face a fundamental problem in the drug discovery process. Up to 90 percent of the human proteins, including many that cause cancer and other diseases, are difficult to target through traditional methods of screening.

Adapting his previous work at the Whitehead Institute for Biomedical Research, Kritzer is able to use baker's yeast to produce large collections of molecules called cyclic peptides. To do this, Kritzer inserted short snippets of DNA into the yeast cells that direct them to make the cyclic peptides. The cells then synthesize tens of millions of different cyclic peptides that can be directly tested for anti-cancer or other activities.

Cyclic peptides are important because they can bind with disease-causing proteins that scientists previously have been unable to target because they do not possess "active sites" or pockets that can easily bind with inhibitory drugs. As a result, drug developers have largely ignored these proteins, says Kritzer. "They are considered undruggable targets, but they include some of the most direct causes of cancer, inflammation and other diseases," he says.

Kritzer will focus his technology on a specific group of proteins called tran
'/>"/>

Contact: Alex Reid
alexander.reid@tufts.edu
617-627-4173
Tufts University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tufts graduate students win $10,000 prizes
2. Tufts wins NCRR grant for Collaborative Cluster in Genome Structure and Developmental Patterning
3. Tufts students host Earth Day with groundbreaking ceremony for solar house
4. Tufts University professor receives IADR Pharmacology/Therapeutics/Toxicology Award
5. Tufts University Prof. Maria Flytzani-Stephanopoulos named as AAAS Fellow
6. Karl Deisseroth of Stanford University receives HFSP Nakasone Award
7. Michigan State University Federal Credit Union Deploys DigitalPersona Pro to Simplify Password Management and Strengthen Security
8. Columbia University Medical Center announces 2010 Katz Prizes in cardiovascular research
9. University of Illinois researchers discover potential new virus in switchgrass
10. Texas A&M University becomes key player in global study to save Earths endangered species
11. Falling in love more scientific than you think, according to Syracuse University professor
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 A 10 a. Conferência Internacional ... BGI de 22-25 de outubro de 2015, em ... está celebrando seu 10 o. aniversário este ano. Desde ... das reuniões mais influentes do mundo no ramo das ... e prazerosos. A ICG-10 se concentra ...
(Date:7/31/2015)... 31. Juli 2015 Die 10. internationale Konferenz zu ... veranstaltet und findet vom 22. bis 25. Oktober ... statt. Die Konferenz feiert in ... 2006 ist die ICG weltweit zu einem der ... ist eines der dynamischsten, enthusiastischsten und angenehmsten wissenschaftlichen ...
(Date:7/30/2015)... MOUNTAIN VIEW, Calif. , July 30, 2015 ... products and services for gene function analysis and ... CRISPR Guide RNA (sgRNA) Knockout Library targeting all ... to specifically and permanently "knock out" a gene,s ... library provides a high throughput screening tool so ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... led by University of Pennsylvania paleontologists has characterized a new ... species, a plant-eating sauropod named Yongjinglong datangi , roamed ... ago. This sauropod belonged to a group known as Titanosauria, ... ever walk the earth. At roughly 50-60 feet ...
... substantial fraction of the Neanderthal genome persists in modern human ... data from 665 people from Europe and East Asia shows ... in the DNA of this contemporary group, whose genetic information ... research proposes that someone of non-African descent may have inherited ...
... 2014 includes science issues with far-reaching implications for an ... research and energy, according to an article in ... the American Chemical Society. The mid-term elections occurring this ... efforts, already stymied by a bitter partisan atmosphere. ...
Cached Biology News:Dinosaur fossils from China help Penn researchers describe new 'Titan' 2Dinosaur fossils from China help Penn researchers describe new 'Titan' 3Neanderthal lineages excavated from modern human genomes 2Neanderthal lineages excavated from modern human genomes 3
(Date:8/28/2015)... IRVINE, CA (PRWEB) , ... August 28, 2015 ... ... leader in Personalized Medicine, presented two studies at the International Spine Intervention ... on July 28th, 2015 through to August 1st, 2015. With a focus on ...
(Date:8/28/2015)... ... , ... Since the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues ... Images such as the Fonz in a lab coat and Large Marge have been posted ... field. , FireflySci is proud to be the only cuvette manufacturer is the ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... 2015 HUYA Bioscience International (HUYA) today announced the ... Society of HTLV-1, held this week at the University ... the Society is to promote research on HTLV-1 and ... technology and research related to these fields to advance ... is proud to support this prestigious conference," said ...
Breaking Biology Technology:Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 2Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 3Proove Biosciences Presents New Research Study at the International Spine Intervention Society’s Annual Scientific Meeting 4Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 2HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 3HUYA Bioscience International Sponsors Japan Society Of HTLV-1 Annual Meeting 4
... ... and hybridoma productivity. , ... Fort Collins, CO (PRWEB) March 3, 2010 -- InVitria’s launch ... created to improve monoclonal antibody productivity and deliver easier purification of the target ...
... , ... ... ... ...
... , ... ... ... ...
Cached Biology Technology:InVitria Optimizes Hybridoma Cell Culture with New Product Zap-Hybridoma 2InVitria Optimizes Hybridoma Cell Culture with New Product Zap-Hybridoma 3China Medical Technologies Reports Third Fiscal Quarter Financial Results 2China Medical Technologies Reports Third Fiscal Quarter Financial Results 3China Medical Technologies Reports Third Fiscal Quarter Financial Results 4China Medical Technologies Reports Third Fiscal Quarter Financial Results 5China Medical Technologies Reports Third Fiscal Quarter Financial Results 6China Medical Technologies Reports Third Fiscal Quarter Financial Results 7China Medical Technologies Reports Third Fiscal Quarter Financial Results 8China Medical Technologies Reports Third Fiscal Quarter Financial Results 9China Medical Technologies Reports Third Fiscal Quarter Financial Results 10China Medical Technologies Reports Third Fiscal Quarter Financial Results 11China Medical Technologies Reports Third Fiscal Quarter Financial Results 12China Medical Technologies Reports Third Fiscal Quarter Financial Results 13China Medical Technologies Reports Third Fiscal Quarter Financial Results 14China Medical Technologies Reports Third Fiscal Quarter Financial Results 15China Medical Technologies Reports Third Fiscal Quarter Financial Results 16China Medical Technologies Reports Third Fiscal Quarter Financial Results 17China Medical Technologies Reports Third Fiscal Quarter Financial Results 18China Medical Technologies Reports Third Fiscal Quarter Financial Results 19China Medical Technologies Reports Third Fiscal Quarter Financial Results 20China Medical Technologies Reports Third Fiscal Quarter Financial Results 21China Medical Technologies Reports Third Fiscal Quarter Financial Results 22Medivation to Host Conference Call at 8:30 a.m. Eastern Time Tomorrow to Discuss Phase 3 Trial Results for Dimebon in Alzheimer's Disease 2Medivation to Host Conference Call at 8:30 a.m. Eastern Time Tomorrow to Discuss Phase 3 Trial Results for Dimebon in Alzheimer's Disease 3
...
... from vaccinia virus is a type I ... negative superhelical turns (also called right- and ... product of the reaction is a covalently ... negative superhelical turns. DNA Topoisomerase I does ...
RatTRAPTM Assay is a solid-phase immunofixed enzyme activity assay for the determination of osteoclast-derived TRACP 5b activity in rat serum....
... AgarACE Enzyme(a) is a unique agarose-digesting ... quantitative recovery of intact DNA or RNA ... thermostable that low melting point (LMP) agarose ... be equilibrated to the reaction temperature before ...
Biology Products: