Navigation Links
Tuberculosis genomes portray secrets of pathogen's success
Date:8/21/2013

land in those environments.

The analysis conducted by Pepperell and her colleagues focused on the role of natural selection, looking at patterns of genetic diversity among 63 TB and related pathogenic mycobacterial genomes gathered from around the globe.

The study shows a highly constrained bacterial genome, with most deleterious mutations quickly discarded. This was especially true for genes essential for causing disease, protein translation and the trafficking and metabolism of inorganic ions, which help control the interaction between the TB pathogen and its human host.

The bacterium's "defense" genes, on the other hand, showed a high degree of tolerance for beneficial mutations, which may play a role in evolution of drug resistance and evasion of the human immune system.

Pepperell notes: "Evolutionary theory predicts that Mycobacterium tuberculosis populations should be vulnerable to extinction. Yet it is obviously highly prevalent. It must have some incredibly clever strategies and tricks to hang on."

As a result, the explosive spread of TB parallels the growth of human populations and takes every advantage of a world where most people live in crowded and impoverished conditions.

The study, according to Pepperell, should help other researchers home in on genes that may be good candidates for targeting with new drugs, and aid disease control strategies that accommodate or even co-opt the bacterium's evolution and help drive its extinction.


'/>"/>

Contact: Caitlin Pepperell
cspepper@medicine.wisc.edu
608-262-5983
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biosignatures distinguish between tuberculosis and sarcoidosis
2. Targeting tuberculosis hotspots could have widespread benefit
3. MIT-designed cooler preserves tuberculosis drugs, records doses
4. Research on improvements in diagnosing and treating tuberculosis
5. Millions of diabetics could die of tuberculosis
6. New approach of resistant tuberculosis
7. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
8. High doses of Vitamin D help tuberculosis patients recover more quickly
9. Scientists reveal how natural antibiotic kills tuberculosis bacterium
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Missing link discovered in the defence mechanism of the tuberculosis pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... A study recently published in the journal ... shows a new role for the protein adenomatous polyposis ... cause of cancer-related deaths in the U.S. , Lead ... Molecular Biosciences and co-leader of the Cancer Biology program ... part of her career trying to understand the various ...
(Date:8/21/2014)... pancreatitis involves the pancreas digesting itself resulting in severe ... the UK around 20,000 patients are diagnosed with the ... cure and treatment is restricted to intravenous fluid and ... Faculty of Life Sciences, who led the research, said ... from gall stones and excessive alcohol intake combined with ...
(Date:8/20/2014)... , Aug. 20, 2014 /CNW/ -  Issue ... and can quickly become life threatening for some children.    ... as 1.2 million Canadians have food allergies and this number ... cent of children are estimated to have food allergies.  ... mild skin irritations and hives to breathing difficulties and loss ...
Breaking Biology News(10 mins):Research offers insight into cellular biology of colorectal cancer 2Research offers insight into cellular biology of colorectal cancer 3Insulin offers new hope for the treatment of acute pancreatitis 2Information Update - Allergens and food safety at school - What's in your child's lunch? 2Information Update - Allergens and food safety at school - What's in your child's lunch? 3
... Network(R) Video Reports , , ... , April 27 The U.S. Supreme Court has denied the ... Richard I. Fine who has never been charged with ... in L.A. County Central Men,s jail for over a year.  Fine attempted to ...
... 2010 Dominio Amigo S.A.S , a .CO,accredited domain name registrar, ... , , ... , CEO, Dominio Amigo S.A.S , commented, "Domainmonster was a,simple choice for ... gTLD launches, securing the very best Internet real estate,for their customers." "With a ...
... NEW BERN, N.C. , April 27 A hurricane ... your business, information, because you really haven,t thought about it until now. ... Atlantic region, now,s the time to update your document storage plans so ... , , ...
Cached Biology News:U.S. Supreme Court Allows 'Coercive Confinement' to Continue in Attorney's Civil Contempt Case 2U.S. Supreme Court Allows 'Coercive Confinement' to Continue in Attorney's Civil Contempt Case 3Dominio Amigo Announce Domainmonster as .CO Technical Partner 2Dominio Amigo Announce Domainmonster as .CO Technical Partner 3Hurricane-Proof Your Information 2
(Date:8/20/2014)... Mass. , Aug. 20, 2014  Decision Resources Group finds ... , Russia , India ... $1.6 billion in 2013, roughly equal to the size of ... however, the BRIC market will experience much faster growth as a ... aging population. Other key findings from Decision Resources Group,s ...
(Date:8/20/2014)... 2014 The 6th Annual Arrowhead ... on October 29-30 in San Francisco, CA. This year’s ... government researchers and clinicians focused on addressing and solving ... In the twelve years since the sequencing of the ... introduced with pharmacogenetic information in the label and molecular ...
(Date:8/20/2014)... Aug. 20, 2014 /PRNewswire-iReach/ -- A case study ... between the school,s bioengineering department and the Intel® ... Intel® Software Academic Program, UCSD,s research focuses on ... human body.  Photo - ... the work of Dr. Todd P. Coleman ...
(Date:8/20/2014)... NJ (PRWEB) August 20, 2014 WriteResult®, ... announced today that it has expanded its myPROpad™ ePRO ... the EQ-5D-5L, one of the most widely used ... measuring general health status. The EQ-5D is used during ... generate a measure that can be used to demonstrate ...
Breaking Biology Technology:BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 2BRIC Vascular Access Device Market Valued at $1.6 Billion in 2013, Similar to the U.S. Market 36th Annual Personalized and Precision Medicine Conference Bringing Together Thought Leaders to Discuss Clinical Implementation, Dx Reimbursement, Big Data, and Sequencing 2Intel and University of San Diego Bioengineering Department Release Case Study on Health Sciences Research 2EQ-5D™ Assessment Now Available for iPad 2
... AUCKLAND, New Zealand, Jan. 6 MicroDose Technologies, ... have entered into a collaboration to investigate the ... generation electronic dry powder inhaler (DPI). Under ... the development of prototypes based upon MicroDose,s inhaler ...
... leader in providing automated, molecular testing solutions, announced today ... to present at the JPMorgan Healthcare Conference, which will ... Francis Hotel in San Francisco, CA. At this conference, ... of the Company at 11:00am on Tuesday, January 13, ...
... in drug-eluting stent technologyNATICK, Mass., Jan. 6 ... today announced that it has acquired Labcoat Limited, ... located in Galway, Ireland. Terms of the ... technology for coating drug-eluting stents that uses precisely ...
Cached Biology Technology:MicroDose and Nexus6 Announce Collaboration to Evaluate Application of Remote Patient Compliance Monitoring Technology with MicroDose's Electronic Dry Powder Inhaler 2MicroDose and Nexus6 Announce Collaboration to Evaluate Application of Remote Patient Compliance Monitoring Technology with MicroDose's Electronic Dry Powder Inhaler 3Boston Scientific Acquires Labcoat Limited 2Boston Scientific Acquires Labcoat Limited 3Boston Scientific Acquires Labcoat Limited 4
...
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
... OrientExpress™ System Modules ... synthesis and directional cloning ... T7 expression vectors ... configuring OrientExpress™ Cloning Systems, ...
...
Biology Products: