Navigation Links
Tuberculosis genomes portray secrets of pathogen's success
Date:8/21/2013

MADISON, Wis. By any measure, tuberculosis (TB) is a wildly successful pathogen. It infects as many as two billion people in every corner of the world, with a new infection of a human host estimated to occur every second.

Now, thanks to a new analysis of dozens of tuberculosis genomes gathered from around the world, scientists are getting a more detailed picture of why TB is so prevalent and how it evolves to resist countermeasures. Writing today (Aug. 21, 2013) in the journal Public Library of Science (PLoS) Pathogens, a team led by University of Wisconsin-Madison researcher Caitlin Pepperell describes a bacterium that marches in lockstep with human population growth and history, evolving to take advantage of the most crowded and wretched human conditions.

"It's as though the bacterium places bets on human behavior," says Pepperell, formerly of Stanford University, and now a professor of medicine and medical microbiology at UW-Madison. "It always bets that humans will go to war, send people to refugee camps, and gather in miserable places. Historically, that's been a winning bet on the bacterium's part."

The PLoS Pathogens study, whose senior author is Marcus Feldman of Stanford, reveals that tuberculosis experienced a 25-fold expansion worldwide in the 17th century, a time when human populations underwent explosive growth and European exploration of Africa, the Americas, Asia and Oceania was at its peak.

"The timing is coincident with expansion, urbanization and colonial migrations of global human populations," Pepperell explains. "These findings suggest that much of the current TB pandemic has its origins in historical events of the last three centuries."

TB is only transmitted by people, and the organism cannot survive in the environment. It thrives, however, in the crowded conditions of prisons, refugee camps and slums, and TB populations tend to be dominated by the bacteria "lucky" enough to
'/>"/>

Contact: Caitlin Pepperell
cspepper@medicine.wisc.edu
608-262-5983
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biosignatures distinguish between tuberculosis and sarcoidosis
2. Targeting tuberculosis hotspots could have widespread benefit
3. MIT-designed cooler preserves tuberculosis drugs, records doses
4. Research on improvements in diagnosing and treating tuberculosis
5. Millions of diabetics could die of tuberculosis
6. New approach of resistant tuberculosis
7. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
8. High doses of Vitamin D help tuberculosis patients recover more quickly
9. Scientists reveal how natural antibiotic kills tuberculosis bacterium
10. Notre Dame research could provide new insights into tuberculosis and other diseases
11. Missing link discovered in the defence mechanism of the tuberculosis pathogen
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... mammals, ravens form different types of social relationships ... also form strict dominance relations. From a cognitive perspective, ... ability in daily social life ("knowing who is nice ... have with each other sets the stage for "political" ... this study have been published in the scientific journal ...
(Date:4/23/2014)... leading a 2 million Food Standards Agency (FSA) project ... and industry workers. , Norovirus outbreaks can rapidly ... batch of frozen strawberries infected 11,000 people in Germany, ... of which strains cause infection and which foods are ... , Researchers will produce data that will help the ...
(Date:4/22/2014)... secret to get your child to behave at the dinner ... Cornell study published in Eating Behaviors , found that ... bite with their front teeth such as drumsticks, whole apples, ... when these foods had been cut. "They were twice ... other kids," said Brian Wansink, Professor and Director of the ...
Breaking Biology News(10 mins):Ravens understand the relations among others 2Biting vs. chewing 2
... Animals that seem identical may belong to completely different species. ... Gothenburg, Sweden, who have used DNA analyses to discover that ... types of worm. The result is one of many suggesting ... considerably larger than we thought. ,"We could be talking about ...
... the University of Leeds have developed chemicals which kill ... including those resistant to existing drugs. , ... (DHODH) - essential to the growth of the parasite ... Says lead researcher Dr Glenn McConkey, from Leeds, Faculty ...
... Maine, government scientists have figured out how to measure snowfall ... the sun - all the while saving money, energy, and, ... energy-efficient ingenuity was the need to help the National Weather ... snowmelt. The problem was this: While the USGS has ...
Cached Biology News:Animals that seem identical may be completely different species 2New hope for advances in treating malaria 2Measuring snow with a bucket, a windmill, and the sun? 2
(Date:1/15/2014)... More than 5 million Americans are currently ... seniors will die with Alzheimer’s or another dementia, according ... shocked many Americans into looking for ways to improve ... age-related cognitive disorders. Jonathan Weisman, president of Biohack Pure, ...
(Date:1/15/2014)... NY (PRWEB) January 15, 2014 The Microcompetition ... a major disease. One of these latent viruses is the ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic inflammatory ... theory, a study found that RA patients have high concentrations ...
(Date:1/15/2014)... 2013 was a banner year of continued innovation ... continued independent research led by the team at Wake ... million grant from the Susanne Marcus Collins Foundation, had ... reviewed journal, Amy Grant highlighted Brainwave Optimization® in First ...
(Date:1/15/2014)... Toronto, ON (PRWEB) January 15, 2014 ... an experimental new therapy for the treatment of tinnitus. ... unique tinnitus frequency, and over a period of weeks to ... Notched Sound Therapy in two forms: Notched Music and Notched ...
Breaking Biology Technology:Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3
... Inc. (NYSE Amex: PIP ) announced today ... its recombinant protective antigen (rPA) anthrax vaccine program.  PharmAthene ... process for the bulk drug substance of its vaccine ... US-based manufacturing facility at Diosynth RTP.   Activities to ...
... 2011 Caliper Life Sciences, Inc. (NASDAQ: ... Inc., an innovative sequencing service provider based in Gaithersburg, ... the 5500xl, SOLiD 4, and Ion Torrent Personal Genome ... will initially focus on sample preparation for exome, whole ...
... June 27, 2011 ,   ReportsnReports ... , Report in its store Browse the complete ... Report now! Search 75000+ Market Research,Reports ... Reports Report Summary Eliminate unnecessary ...
Cached Biology Technology:PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer 2PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer 3EdgeBio Selects Caliper's Sample Preparation Suite for High Throughput and Benchtop Sequencing Workflows 2ReportsnReports - Daptomycin - Comprehensive Patent Search 2ReportsnReports - Daptomycin - Comprehensive Patent Search 3ReportsnReports - Daptomycin - Comprehensive Patent Search 4ReportsnReports - Daptomycin - Comprehensive Patent Search 5
... polyclonal antibody raised against a ... Immunogen: K6HF (NP_004684, ... partial recombinant protein with GST ... Number: NM_004693 ...
... The binding specificity and signaling of the ... to be modified by alternative splicing--which has ... SpliceArrays you can perform a classical expression ... the different alternatively spliced forms of the ...
... form of cell suicide, which follows a ... of this process is a cascade of ... participate in a series of reactions that ... and result in the cleavage of protein ...
...
Biology Products: