Navigation Links
Tuberculosis drug shows promise against latent bacteria
Date:9/12/2008

A new study has shown that an investigational drug (R207910, currently in clinical trials against multi-drug resistant tuberculosis strains) is quite effective at killing latent bacteria. This revelation suggests that R207910 may lead to improved and shortened treatments for this globally prevalent disease.

Despite numerous treatment advances, tuberculosis (TB) remains a serious disease fueled by co-infection of HIV patients, the rise of drug-resistant strains, and the ability of Mycobacterium tuberculosis to become dormant and linger in the lungs. In fact, one third of the world population is infected, asymptomatically, with latent TB and is at risk of developing active TB disease during their life time.

Anil Koul and colleagues at Johnson & Johnson tested R207910 on dormant M. tuberculosis in three different laboratory models of latency. R207910 targets a protein (ATP synthase) essential for making cellular energy (ATP) in actively replicating TB. The researchers reasoned that even dormant bacteria, which are essentially physiologically "turned off", still need to produce small quantities of ATP to survive. As such, a block in ATP synthesis might be an Achilles heel for killing dormant bacteria.

This reasoning proved to be correct and R207190 was able to kill dormant bacteria by greater than 95% whereas current drugs like isoniazid had no effect. Surprisingly, they found that R207910 is slightly more effective in killing dormant bacteria as compared to actively replicating ones, a unique spin as all known TB drugs are more effective on replicating bugs. Koul and colleagues hope to validate these results clinically, and note that ATP synthase should be looked at as a drug target for other persistent bacterial infections.


'/>"/>

Contact: Nick Zagorski
nzagorski@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Preventing tuberculosis reactivation
2. Cornell researcher seeks clues to how tuberculosis infects cells
3. New drug targets may fight tuberculosis and other bacterial infections in novel way
4. Vitamin E may increase tuberculosis risk in male smokers with high vitamin C intake
5. Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment
6. Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis
7. Potential new drug target to fight tuberculosis identified
8. Clinical trial for new tuberculosis vaccine
9. Research shows skeleton to be endocrine organ
10. Clones on task serve greater good, evolutionary study shows
11. Study shows link between alcohol consumption and hiv disease progression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/25/2015)... LAKE CITY and BELLEVUE, Wash. ... global leader in advanced robotic systems, announced today it ... robotic unmanned ground vehicle (UGV), at the National Tactical ... City.  The Guardian S is the ... the culmination of years of research and in-field trials ...
(Date:8/20/2015)... , Aug. 20, 2015   Sensory, ... on improving the user experience and security of ... technologies, today announced that its TrulySecure™ ... authentication software to be FIDO Certified™. ... for compliance with the FIDO UAF (Universal Authentication ...
(Date:8/18/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/9dmm6l/global_biometric ... "Global Biometric Authentication & Identification Market: Focus On ... 2015-2020" report to their offering. ... market is expected to grow at an estimated ... generate over $25 billion (approximately) by 2020 as ...
Breaking Biology News(10 mins):Sarcos to Debut First-of-its-Kind Snake Robot 2Sarcos to Debut First-of-its-Kind Snake Robot 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 2TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 3TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 4TrulySecure From Sensory Becomes First Face and Voice Biometrics Technology to be FIDO UAF Certified 5Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2
... could lead to improved varieties of the crop most ... Scientists funded in part by the Biotechnology and Biological ... to uncover key genes that control the specific characteristics ... out at the Scottish Crop Research Institute, Birmingham University ...
... of birds. Without them, birds could not fly or ... Experimentally testing one current hypothesis, developmental biologists at University ... answer. , In a previous study, UW anatomy professor ... hedgehog (Shh) and bone morphogenetic protein 2 (Bmp2) must ...
... are more likely to bounce back from extreme coastal ... knowledge, according to a report published in Science. , ... valuable insight into handling extreme coastal disasters - inevitable ... by 2030 and global warming continues to exacerbate extreme ...
Cached Biology News:Whisky fans can drink to crop research 2Molecular mechanism of feather formation found 2Molecular mechanism of feather formation found 3Environmental lessons from tsunami as world's coastal population doubles 2
(Date:8/27/2015)... 2015  Neogen Corporation (NASDAQ: NEOG ) announced ... United Kingdom -based Lab M Holdings, a ... diagnostic systems. Lab M was founded ... of microbial testing and diagnostic products for the global ... currently sells into more than 70 countries worldwide, and ...
(Date:8/27/2015)... , Aug. 27, 2015 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ... and six-month periods ended June 30, 2015. Biorem,s complete second quarter ... ). FINANCIAL HIGHLIGHTS: in ,000,s except earnings per shareThree-months ended ... 2014 , 2015 , 2014 Revenue ... , 4,433 Gross profit , 1,656 , ...
(Date:8/27/2015)... ... August 27, 2015 , ... METTLER TOLEDO's web-based ... down the product choices to a manageable shortlist of bench and floor scales ... models that fit best with the customer’s industry and application. , Side-by-side ...
(Date:8/26/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... quarter ended June 30, 2015. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... Oral Amp B program, rapidly advancing towards the ... Rae , President & CEO of iCo Therapeutics. "We ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3METTLER TOLEDO Updates Online Scale Selection Tool 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3
... , , ... ... ... , ...
... ... information on fertilizers, soil fertility and the critical agricultural issues that face Africa, has ... ... March 3, 2010 -- AfricaFertilizer.org , a global forum to disseminate and exchange ...
... ... , ... , , , ... ...
Cached Biology Technology:Anavex comments on failure of Pfizer and Medivation's Alzheimer's investigational drug Dimebon during Phase 3 clinical trials 2Anavex comments on failure of Pfizer and Medivation's Alzheimer's investigational drug Dimebon during Phase 3 clinical trials 3Anavex comments on failure of Pfizer and Medivation's Alzheimer's investigational drug Dimebon during Phase 3 clinical trials 4AfricaFertilizer.org to Increase Agricultural Productivity and Knowledge Across the African Continent 2AfricaFertilizer.org to Increase Agricultural Productivity and Knowledge Across the African Continent 3AfricaFertilizer.org to Increase Agricultural Productivity and Knowledge Across the African Continent 4Protalix Announces Successful GMP Manufacturing Audit by Israel's Ministry of Health 2Protalix Announces Successful GMP Manufacturing Audit by Israel's Ministry of Health 3Protalix Announces Successful GMP Manufacturing Audit by Israel's Ministry of Health 4Protalix Announces Successful GMP Manufacturing Audit by Israel's Ministry of Health 5
...
...
Smac/DIABLO (CT) - IgG for Western Blotting, Host: Rabbit Family: Smac/DIABLO...
... recombinant human angiogenin expressed in ... Physical form: Lyophilized from a ... phosphate buffered saline. Titertest ... Titertest values: capture ELISA ...
Biology Products: