Navigation Links
Truly sick or simply scared?
Date:8/19/2007

BOSTON Scientists at Pacific Northwest National Laboratory have discovered a way to increase the sensitivity of test strips that will enable creation of a portable biosensor that can address a major concern associated with incidents involving chemical or nerve agents the need to quickly distinguish between individuals who have been exposed and the worried well.

The sensor components resemble a pregnancy test strip and a small glucose testing meter. Its development will be discussed by principal investigator Yuehe Lin at the national meeting of the American Chemical Society.

Every disease has biomarkers, a change in the proteins that announces something is wrong. Lin and his team are creating a nanoparticle label that can increase the ability of a sensor to detect and interpret the message of biomarkers.

Current test strip based-immunoassay technology has very good selectivity, but it can only give a positive or negative response, Lin said.

The researchers are working with an electrochemical immunoassay approach. This involves using the antibody of a specific disease a protein produced in response to an invading bacterium or other foreign substance to attract the biomarker. Lin found that labeling a second antibody with a nanoparticle amplifies the biomarkers signal. Greater amplification means more precise readings.

Researchers at PNNL are developing a portable biomonitor to rapidly evaluate tiny samples of blood or saliva for exposure to nerve agents.

Lin achieves this by removing the iron from a nanoparticle-sized ball of the protein ferrin, creating an empty cage called apoferritin, which he then loads with another metal, such as cadmium. The cadmium-fi lled cage is attached to one end of the reporting antibody, and the immuno-reaction product becomes electroactive.

The electrochemical signal is amplified several hundreds to thousand times because of the metal ions, Lin said. This level of sensitivity will allow detectors to be very precise in identifying the concentration of biomarkers in biological samples.


'/>"/>

Contact: Geoff Harvey
geoffrey.harvey@pnl.gov
509-372-6083
DOE/Pacific Northwest National Laboratory
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... , Jan. 5, 2017  Delta ID Inc., a ... scanning technology for automotive at CES® 2017. Delta ID ... ) to demonstrate the use of iris scanning as ... authenticate the driver in a car, and as a ... driving experience. Delta ID and Gentex will ...
(Date:12/22/2016)... -- As part of its longstanding mission to improve genetic literacy ... released its latest children,s book, titled The One ... topics of inheritance and variation of traits that are part ... school classrooms in the US. The book ... Killoran , whose previous book with 23andMe, You ...
(Date:12/19/2016)... BARCELONA , España y TORONTO , 19 ... fusión con Northern Biologics Inc. que permitirá el desarrollo acelerado de ... ensayos clínicos en varios tipos de tumor en 2017, con múltiples ... ... de su clase con objetivo en el factor inhibidor de leucemia ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... ... delivery of product vigilance software to leading biopharmaceutical and medical device manufacturers and ... is a fully 21 CFR Part 11-compliant email client designed to provide product ...
(Date:1/19/2017)... , Jan. 19, 2017  ArmaGen, Inc., ... Schmidt , Ph.D., as chief executive officer, as ... directors. Dr. Schmidt brings to ArmaGen more than 17 ... research and development of biotherapeutics and pharmaceuticals. ... with the diverse experience and skillset necessary to ...
(Date:1/19/2017)... ... January 18, 2017 , ... ... of Health (NIH) to update its Data Sharing Policy. Specifically, the nation’s leading ... grant applications subject to the existing policy. AMIA recommended that NIH earmark funding ...
(Date:1/19/2017)... ... January 19, 2017 , ... FireflySci Inc. is a go-getter type ... tremendous growth is accounted to two main factors. The first is the amazing ... of vendors supplying FireflySci products all around the world. , 2016 was a tremendous ...
Breaking Biology Technology: