Navigation Links
Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
Date:6/27/2011

Saranac Lake, N.Y. Researchers from the Smiley lab at the Trudeau Institute have now identified a single component of the plague causing bacterium that can be used as a vaccine. This single "subunit" could potentially be used to create a safer form of a T cell-stimulating plague vaccine. The new data is featured in the July issue of The Journal of Immunology.

"To date, there has been little progress in the development of safe and effective vaccines for plague or similar bioweapons," said Dr. Stephen Smiley, a leading plague researcher and Trudeau Institute faculty member. "Our data identifies a single component of the plague causing bacterium seen by T cells. This could be a key discovery as we seek to develop a plague vaccine."

The lab envisions that this subunit might be added to others already being studied for their ability to induce antibody responses. Together, these multiple subunits might safely induce both antibody and T cell responses, thereby better combating plague.

According to Dr. Smiley, there is no licensed plague vaccine in the United States. Together with postdoctoral associate Jr-Shiuan Lin, he is working to develop a vaccine that will protect members of the armed services and public from a "plague bomb."

Plague is caused by Yersinia pestis, arguably the most deadly bacteria known to man. Yersinia pestis infections of the lung, known as pneumonic plague, are extremely lethal and usually lead to death within a week of infection.

This could be a major discovery in the ongoing battle between scientists working to develop a vaccine to protect against plague and the terrorists who seek to use plague as a weapon. Many of the highest priority bio-terror concerns are caused by bacteria that acutely infect the lung. These include anthrax, tularemia and plague.

Most of the plague vaccine candidates that have been studied aim to stimulate B cells to produce plague-fighting antibodies. However, animal studies suggest that antibodies may not be enough to protect humans from pneumonic plague. The Smiley laboratory has shown that T cells can also fight plague. The lab previously demonstrated that an immunization with an experimental vaccine stimulates the production of T cells that provide partial protection against pneumonic plague. This vaccine consisted of a live but weakened version of the plague causing bacterium.

Live vaccines are often effective, but they can be difficult to license because they have the potential to grow within immunocompromised recipients and inadvertently cause disease.

Additionally, Dr. Smiley believes these studies may help us learn to combat other kinds of pneumonia: "Bacterial pneumonia is one of the most common causes of death in hospitals and, like plague, many of these pneumonias are caused by bacteria that we may need to combat with both antibodies and T cells."


'/>"/>

Contact: Karen Sharma
518-891-3080
Trudeau Institute
Source:Eurekalert  

Related biology news :

1. Partnership to accelerate Trudeau Institute discoveries to patient care
2. Scripps Research Institute Scientist Knighted by Italian Republic
3. Significant litter of cheetah cubs born at Smithsonian Conservation Biology Institute
4. Research Institute of the MUHC awarded $1.4M grant
5. Clemson University institute to study vertical farming feasibility in Charleston, S.C.
6. HHMI helps summer institute expand to regional sites
7. Weizmann Institute scientists discover: A protein that contributes to obesity
8. UC Berkeley launches Synthetic Biology Institute to advance research in biological engineering
9. La Jolla Institute identifies new therapeutic target for asthma, COPD and other lung disorders
10. Allen Institute for Brain Science announces first comprehensive gene map of the human brain
11. NYU Cancer Institute experts present at the AACR 102nd Annual Meeting 2011
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
(Date:4/28/2016)... Sweden , April 28, 2016 First ... M (139.9), up 966% compared with the first quarter of 2015 ... profit totaled SEK 589.1 M (loss: 18.8) and the operating margin ... 7.12 (loss: 0.32) Cash flow from operations was SEK ... The 2016 revenue guidance is unchanged, SEK 7,000-8,500 M. ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:3/31/2016)... 31, 2016   ... the "Company") LegacyXChange is excited to release ... soon to be launched online site for trading 100% ... ) will also provide potential shareholders a sense of ... to an industry that is notorious for fraud. The ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of ... the Cary 5000 and the 6000i models are higher end machines that use the ... of the spectrophotometer’s light beam from the bottom of the cuvette holder. , ...
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a leader ... “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research professionals, ... providing practical tips, tools, and strategies for clinical researchers. , “The landscape of ...
(Date:6/23/2016)... , June 23, 2016   Boston Biomedical ... novel compounds designed to target cancer stemness pathways, ... been granted Orphan Drug Designation from the U.S. ... of gastric cancer, including gastroesophageal junction (GEJ) cancer. ... designed to inhibit cancer stemness pathways by targeting ...
(Date:6/23/2016)... , June 23, 2016 A person commits a ... crime scene to track the criminal down. An ... Food and Drug Administration (FDA) uses DNA evidence to track ... Sound far-fetched? It,s not. The FDA has increasingly ... support investigations of foodborne illnesses. Put as simply as possible, ...
Breaking Biology Technology: