Navigation Links
Trudeau Institute announces its latest discovery in the fight against tuberculosis
Date:10/18/2011

Saranac Lake, N.Y. New research from the Trudeau Institute may help in the ongoing fight against tuberculosis. Dr. Andrea Cooper's lab has discovered a connection between the development of new lymphoid tissue within the lung and protection against the disease. The new data will be published in the November 1 print issue of The Journal of Immunology (Vol. 187, Num. 10) and is available now online ahead of print.

Tuberculosis (TB for short) is a deadly infectious disease caused by infection with Mycobacterium tuberculosis that affects many people throughout the world. Tuberculosis normally attacks the lungs, but can also affect other parts of the body. It is spread through the air when people with active TB infection cough, sneeze or otherwise transmit their saliva through the air. Left untreated, TB can kill more than 50 percent of its victims.

"In the model examined by my laboratory, the absence of a specific cytokine resulted in poor development of new lymphoid tissue," said Dr. Cooper. "There was an associated loss of a molecule that helps recruit protective cells from the blood to the site of infection within the lung. Although this lymphoid tissue has been seen in tuberculosis lesions in the lung in the past, this is the first time that this part of the immune response has been associated with an active role in protection against tuberculosis."

By understanding how different components of the immune response control the bacteria that cause tuberculosis, public health officials/health practitioners will be better positioned to protect against the disease with a combination of vaccination, immunotherapeutics and drugs. The new findings could prove particularly useful as cells within this lymphoid tissue have not been previously targeted by vaccination and may provide novel avenues to improve current vaccines.

The research was performed by current and past members of the Trudeau Institute, including scientists from the University of Pittsburgh and the University of Rochester. Dr. Shabaana Khader, Dr. Javier Rangel-Moreno and Dr. Troy Randall were also involved with the study.


'/>"/>

Contact: Kim Godreau
kgodreau@trudeauinstitute.org
518-891-3080 x561
Trudeau Institute
Source:Eurekalert

Related biology news :

1. Partnership to accelerate Trudeau Institute discoveries to patient care
2. Trudeau Institute announces new discovery in battle against plague and bacterial pneumonias
3. Trudeau Institute announces new discovery in battle against infections
4. Wistar Institute researcher receives New Innovator award from NIH
5. Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health
6. Broad Institute awarded major grant to bolster epigenomics research
7. Salk researcher Terry Sejnowski elected to Institute of Medicine
8. EPA teams with National Geographic Society and World Resources Institute to map ecosystem services
9. M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
10. House Ear Institute, TGen and Belgian researchers identify gene in age-related hearing loss
11. Rutgers receives US$10 million to establish Institute for Food, Nutrition and Health
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... , March 31, 2016 ... ) ("LegacyXChange" or the "Company") LegacyXChange is ... users of its soon to be launched online site ... https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also provide potential shareholders ... of DNA technology to an industry that is notorious ...
(Date:3/29/2016)... Florida , March 29, 2016 ... the "Company") LegacyXChange "LEGX" and SelectaDNA/CSI Protect are pleased ... in ink used in a variety of writing instruments, ... Buyers of originally created collectibles from athletes on LegacyXChange ... forensic analysis of the DNA. Bill ...
(Date:3/22/2016)... India , March 22, 2016 /PRNewswire/ ... market research report "Electronic Sensors Market for Consumer ... Proximity, & Others), Application (Communication & IT, ... Geography - Global Forecast to 2022", published ... industry is expected to reach USD 26.76 ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... ... 23, 2016 , ... UAS LifeSciences, one of the leading ... UP4™ Probiotics, into Target stores nationwide. The company, which has been manufacturing high ... its list of well-respected retailers. This list includes such fine stores as Whole ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... Houston Methodist Willowbrook Hospital has signed ... to serve as their official health care provider. ... will provide sponsorship support, athletic training services, and ... volunteers, athletes and families. "We are ... and to bring Houston Methodist quality services and ...
Breaking Biology Technology: