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Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

RNAs that uniquely represent primary and metastatic tumors, and that are specifically deregulated in that stage of the disease, says co-author Dr. Pierluigi Gasparini, a postdoctoral researcher in Huebner's laboratory.

The results define microRNA expression signatures that characterize and contribute to the differences between primary and metastatic tumors.

"We now want to learn which of these deregulated microRNAs might represent early biomarkers for cancer or metastasis detection," Gasparini says.

The study's key technical findings include:

  • The microRNA signatures correlated with prognosis and were correlated with changes in mRNA expression;
  • Two microRNA signatures were predictive of overall survival and distant disease-free survival, respectively, in patients 50 years of age or younger;
  • mRNA expression profiling resulted in clustering of triple-negative breast cancer into four molecular subclasses with different expression signatures.

"We believe these findings will be a reference point not only for our lab but also for many other research teams that might not have access to large patient populations, and hope that they will accelerate even more research on triple-negative breast cancer," Huebner says.


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Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

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