Navigation Links
Triple-negative breast cancer subtypes identified using microRNA
Date:2/7/2013

  • Triple-negative breast cancer is an aggressive form of breast cancer that has few treatment options;
  • This large-scale study shows that abnormal levels of small molecules called microRNA can be used to classify this malignancy into four subtypes;
  • The findings could lead to new ways to identify the best therapy for individual patients and to more effective therapies in the future.

COLUMBUS, Ohio A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy.

The findings, by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) working with collaborators in Italy, could lead to new screening methods, prognostic markers and perhaps new targeted treatments for this aggressive and often-fatal form of breast cancer.

The study is published in the journal PLOS ONE.

"The treatment of women with triple-negative breast cancer is challenging because this malignancy can be very different genetically from one patient to another," says co-senior investigator Dr. Charles Shapiro, director of Breast Medical Oncology and professor of internal medicine at the OSUCCC James.

"We believe these microRNA signatures define novel sub-sets of triple-negative breast cancer and offer new insights into the biology of the disease and better ways to treat these patients," Shapiro says.

The microRNAs that compose the signatures are involved in regulating cell growth, proliferation and survival, and in cell movement and migration.

"These findings strongly suggest that microRNAs play an important role in triple-negative breast cancer and might be used to better identify the most effective treatment for a patient's tumor," says co-senior investigator and researcher Dr. Kay Huebner, professor of molec
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. TGen-US Oncology data guides treatment of metastatic triple-negative breast cancer patients
2. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
3. In breast cancer metastasis, researchers identify possible drug target
4. Vitamin D holds promise in battling a deadly breast cancer, Saint Louis University researchers say
5. Does your job increase your breast cancer risk?
6. Breast cancer drug could halt other tumors
7. UCLA researchers to study depression in breast cancer survivors
8. Scientists unravel resistance to breast cancer treatment
9. High levels of DDT in breast milk
10. Breast milk promotes a different gut flora growth than infant formulas
11. New method provides fast, accurate, low cost analysis of BRCA gene mutations in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... VILNIUS, Lithuania , Nov. 4, 2014 /PRNewswire/ ... identification technologies, today announced that the latest version ... place in the Ongoing MINEX evaluation ... interoperability of fingerprint algorithms using the INCITS 378 ... a mandatory requirement in public tenders in ...
(Date:11/3/2014)... A University of Colorado Cancer Center study ... Academy of Sciences describes the activity of a ... Interleukin 37 or IL-37. It has been known to ... in the adaptive immune system: IL-37 inhibits the ability ... antigens. , "Knowing this mechanism that underlies IL-37,s effect ...
(Date:11/3/2014)... and preterm birth are linked to increased risk for ... the American College of Rheumatology (ACR) journal, Arthritis ... and pre-term babies were not at greater risk of ... According to the ACR, 27 million Americans over the ... of OA range from mild to severe and include ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2
... discovery by Monash University scientists could see humble cotton ... devices capable of detecting diseases such as kidney failure ... have used ordinary cotton thread and sewing needles to ... is the size of a postage stamp. Microfluidic ...
... look identicalnot to mention drabto the human eye. But that,s ... essentially colorblind. A new study published online on February 25th ... that the fish can easily tell one species from another ... on their faces. Although scientists have long known that ...
... that a microbe called Trichodesmium , a member of ... budget. New research results reported on-line today in a ... may have to share its nitrogen-fixing throne: two others ... UCYN-A and Crocosphaera watsonii , are also abundant in ...
Cached Biology News:How long is a piece of thread? Long enough to save a life 2Fish can recognize a face based on UV pattern alone 2More than 1: Long-reigning microbe controlling ocean nitrogen shares the throne 2
(Date:11/27/2014)... -- Research and Markets  has announced ... Report 2014" report to their offering. ... Palmitic Acid Industry Report 2014 is a professional and ... palmitic acid industry. The report provides a ... and industry chain structure. The palmitic acid market analysis ...
(Date:11/27/2014)... Spartan Bioscience today announced that it has received ... regulatory approval for its Spartan RX CYP2C19 System ... 60 minutes from a non-invasive cheek swab. , The ... to determine therapeutic strategies for drugs metabolized by the ... world’s most commonly prescribed drugs such as Plavix® (clopidogrel), ...
(Date:11/27/2014)... 2014 First articles published ... Elsevier , a world-leading provider of scientific, ... to announce the launch of a new journal: ... The launch of Extreme Mechanics Letters ... forefront of applied sciences such as micro and nanotechnologies, ...
(Date:11/27/2014)... EDINBURGH , November 27, 2014 ... on revolutionising the management of tooth decay, today ... study of its Calcivis® Caries Activity Imaging System. ... is a sophisticated medical device and consumable combination ... dental caries (tooth decay). It involves a unique, ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 2Spartan Bioscience Receives Korean Regulatory Approval for First Rapid DNA Test of Mutations Affecting Metabolism of Common Drugs 3Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 2Elsevier Announces the Launch of a New Journal: Extreme Mechanics Letters 3Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 2Calcivis Completes Clinical Study of Novel Caries Activity Imaging System 3
... 2011 Sigma-Aldrich® (NASDAQ: SIAL ) ... Directors declared a quarterly cash dividend of $.18 per share. ... of record on December 1, 2011. The Board ... the Company,s repurchase authorization.  This action brings the total authorization ...
... Star Line Group , U.S. Advisors ... reinsurance program in response to the final regulations published recently ... "We recognize the unique requirements of organizations that want ... need to moderate their downside risk in an affordable fashion," ...
... Nov. 8, 2011 ACCESS PHARMACEUTICALS, INC. ... proprietary drug-delivery platforms to develop treatments in areas of ... it has entered into an agreement with a major ... CobOral technology for the targeted delivery of RNAi therapeutics. ...
Cached Biology Technology:Sigma-Aldrich (NASDAQ: SIAL) Declares Quarterly Dividend. 2New ACO Reinsurance Program Launched by Star Line Group, U.S. Advisors and Ascendent Care 2Access Pharmaceuticals Signs Agreement for CobaCyte® and CobOral® in RNAi Therapeutic Delivery 2Access Pharmaceuticals Signs Agreement for CobaCyte® and CobOral® in RNAi Therapeutic Delivery 3
... Tracker Intracellular Localization Kit provides a straight ... siRNA, of your design, in an efficient ... experiments. Subcellular localization and functional inhibition of ... introduction of the labeled siRNA into mammalian ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Invasion Assay is designed to determine the ... a significant barrier to invasion or to ... a convenient, high-throughput, 96-well format. The 8 ... types of adherent cells such as epithelial, ...
... GrabIt™ Kits are designed for the study ... a pull-down method. Proteins that interact with ... fusion proteins are copurified using affinity resins ... retained on a spin filter. The complexes ...
Biology Products: