Navigation Links
Triple-combo drug shows promise against antiviral-resistant H1N1, UAB researcher says
Date:10/27/2009

BIRMINGHAM, Ala. An experimental drug cocktail that includes three prescriptions now widely available offers the best hope in developing a single agent to treat drug-resistant H1N1 swine flu, says a virology researcher in the University of Alabama Birmingham (UAB) Division of Pediatric Infectious Diseases.

In laboratory testing, the triple combination of oseltamivir (Tamiflu), amantadine (Symmetrel) and ribavirin showed a significant capacity to stop flu-virus growth, says Mark Prichard, Ph.D, who serves on the board of directors of the International Society for Antiviral Research. The combo drug works better in the test tube than currently recommended single or double antiviral therapies used to treat both seasonal and swine flu strains, he says.

Prichard presented his data in September at the annual Interscience Conference on Antimicrobial Agents and Chemotherapy held in San Francisco. The triple-combo testing is led by Adamas Pharmaceuticals, Inc. based in Emeryville, California.

"These findings suggest strongly that the triple combo is highly synergistic against virus replication, meaning it strikes multiple targets within H1N1 flu and other strains," Prichard says. "Only human testing will determine for sure, but this combo has the potential to be the antiviral therapy of choice for serious flu infection and to address Tamiflu resistance."

The synergy was seen in swine flu and seasonal flu strains, as well as H3N2 seasonal flu and the highly pathogenic H5N1 avian influenza strain, Prichard says. The dosing and timing of the combo mixture is protected information by Adamas. The company is starting human testing in the Southern Hemisphere, and has plans to begin human testing in North America once approval is obtained.

Because flu infection typically lasts for shorter periods of time than many other chronic infections, the three-pronged antiviral approach means the circulating strains of flu virus may not have time to develop resistance to the combo, Prichard says. "That's why this research is so timely, and why antiviral safety and testing data is crucial.

"If this triple combo could reduce the impact to families and the healthcare system that comes from serious flu cases, we would be thrilled."


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related biology news :

1. Study shows how carbon nanotubes can affect lining of the lungs
2. Research shows treating HIV-AIDS with interleukin-2 is ineffective
3. Being a standout has its benefits, study shows
4. Trackway analysis shows how dinosaurs coped with slippery slopes
5. Study shows that color plays musical chairs in the brain
6. Diabetes drug shows promise in fighting lethal cancer complication
7. Trial of new treatment for advanced melanoma shows rapid shrinking of tumors
8. New report shows rising tide of fractures in Asia
9. University of Toronto study shows disparity of effect of climate change on UV radiation
10. Study shows how disruption of spectrin-actin network causes lens cells in the eye to lose shape
11. Medicine wheel model for nutrition shows promise for control of type 2 diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
(Date:3/20/2017)... At this year,s CeBIT Chancellor Dr. Angela ... The Chancellor came to the DERMALOG stand together with the Japanese Prime ... partner country. At the largest German biometrics company the two government leaders ... iris recognition as well as DERMALOG´s multi-biometrics system.   ... ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, ... Simple," and 23andMe , the leading personal genetics ... choices.  Zipongo can now provide customers with personalized nutrition ... goals and biometrics, but also genetic markers impacting how ... Zipongo,s personalized food decision support platform uses biometrics ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... ... March 29, 2017 , ... (March ... International Mexico has been approved as an active member of the Mexican ... protection among distributers and consumers in relationship marketing. This professional organization fosters loyal ...
(Date:3/29/2017)... , ... March 29, 2017 , ... ... instrumentation for cell-based assays, disperses a quarterly travel award to noteworthy scientists who ... the company announced that its new round of awards are being given to ...
(Date:3/29/2017)... , March 29, 2017 /PRNewswire/ - The University of ... Nordion, a business of Sterigenics International, and General Atomics ... been submitted to the U.S. Nuclear Regulatory Commission (NRC). ... production of molybdenum-99 (Mo-99). Once operational, production from this ... U.S. demand for Mo-99, which currently must be imported ...
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... NetDimensions Learning to replace paper-based processes and enhance training plan management for consistent ... very pleased to partner with the SHL Group to help improve and streamline ...
Breaking Biology Technology: