Navigation Links
Triggering muscle development -- a therapeutic cure for muscle wastage?
Date:6/30/2009

Scientists in the UK and Denmark have shown that if elderly men were given growth hormone and exercised their legs showed an appreciable muscle mass increase. Dr. Geoff Goldspink (Royal Free and University College Medical School, UK) says: "This raises the question: Can age-related loss of muscle strength and increased fragility be ameliorated by the therapeutic application of mechano growth factor (MGF)?". There is hope that MGF can also help sufferers of diseases such as muscular dystrophy, ALS, renal disease or cancer, for whom intensive exercise is not an option. It may even prove useful to ameliorate muscle loss resulting from long periods in zero-gravity conditions during space travel. Dr. Mark Lewis (University College London, UK) will present their latest results on how MGF exerts its effects during his talk at the Society of Experimental Biology Annual Meeting in Glasgow on Wednesday 1st July 2009.

When muscles are stretched during exercise, they produce a specific substance known as mechano growth factor (MGF) that activates stem cells already present in the tissue. Once activated, these progenitor cells begin to divide, creating additional muscle fibres and increasing the size and strength of the muscle. In addition to intensive exercise, muscles need to be stimulated by growth hormone (GH) in order to release MGF. Since there is a natural decrease in the levels of this hormone as we age, this may combine with the lack of intensive physical activity to cause muscle wasting in elderly people. "The downside", warns Dr. Goldspink, "is that MGF has great potential for doping in sports. A synthetic version is already available over the internet, and although it is still very expensive, it is expected that new technologies will bring down the price to make it comparable to that of human insulin".


'/>"/>

Contact: Cristian C. A. Bodo
Cristian.Bodo@kcl.ac.uk
44-794-258-7047
Society for Experimental Biology
Source:Eurekalert

Page: 1

Related biology news :

1. Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy
2. Muscle atrophy through thick but not thin
3. Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue
4. Stanford scientists turn adult skin cells into muscle and vice versa
5. Grouping muscles to make controlling limbs easier
6. Oral contraceptives impair muscle gains in young women
7. Oral contraceptives impair muscle gains in young women
8. Astronauts may need more intense workouts to maintain muscle fitness in space
9. As good as it gets: Octogenarian muscles dont get stronger with exercise
10. Stem cell breakthrough: Monitoring the on switch that turns stem cells into muscle
11. Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... finds life can persist in a cold, dark world. ... team that examined waters and sediments from a shallow ... the extreme environment supports microbial ecosystems. , The ... colleagues has implications for life in other extreme environments, ... findings are published in the current edition of the ...
(Date:8/20/2014)... MA Using population-based screening outcomes of approximately 3 ... including four researchers at the University of Massachusetts Medical ... immunodeficiency (SCID) can be successfully implemented across public health ... published in the Aug. 20 issue of the ... ) showed the rate of SCID in newborns is ...
(Date:8/20/2014)... are athletes who have suffered concussions ready to return ... found that high school athletes who head back on ... a significant regression in their abilities to simultaneously walk ... seen in changes in their balance and/or altered walking ... of the 12 had returned to activity in less ...
Breaking Biology News(10 mins):University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3Recovery reversal seen in Oregon study of returning concussed athletes 2Recovery reversal seen in Oregon study of returning concussed athletes 3
... for Biodiversity Science (QCBS) cordially invites you to its ... from government, the private sector and NGOs to reflect ... the International Year of Biodiversity. CONFIRMED SPEAKERS TO ... the H. John Heinz III Centre for Science, Economics, ...
... tonnes of carbon dioxide a year from the time food ... more than 20% of total yearly emissions. That is what ... the first time that human excrements contribute to water pollution, ... from the Universidad de Almera (UAL) has estimated the environmental ...
... the University of Illinois at Chicago have been awarded more ... Institute to investigate both the acquired and familial causes of ... diagnosis and targets for cures. The five years of ... John Solaro, distinguished university professor and head of physiology and ...
Cached Biology News:Every person emits 2 tons of CO2 a year through eating 2$12 million grant to probe root causes of heart failure 2
(Date:8/21/2014)... Gallus BioPharmaceuticals , LLC, ... manufacturing organization (CMO) announced today that it has ... company focused on the development of innovative approaches ... anti-prostate specific membrane antigen (PSMA) monoclonal antibody used ... the agreement the antibody will be produced in ...
(Date:8/20/2014)... An analysis of patented university inventions licensed to ... path to commercialization. To open these roadblocks, the ... results during the discovery stage could lead to ... are frequently derived from discoveries made in university ... well known during clinical trials, which have a ...
(Date:8/20/2014)... High performance computing (HPC) will ... complete climate and Earth system model to address ... , Eight national laboratories, including Lawrence Livermore ... for Atmospheric Research, four academic institutions and one ... national laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los ...
(Date:8/20/2014)... Not long ago, it was more or less ... in the development cycle – even after the final ... that, like many things GxP, expectations for early E&L ... drug sponsors have been required by authorities to provide ... I/II. It’s not only clinical trial material containers causing ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... Report Represents Major Step in Cancer Genome Research, ... a Beckman Coulter company, announced today that its,Genomic ... released study from,Johns Hopkins Kimmel Cancer Center. The ... the discovery of 200 genes linked to breast ...
... Biosciences Inc. announces the,launch of its SurgiMend(TM) Collagen ... 510(k) clearance from the U.S. Food and Drug,Administration ... and,reconstructive surgery, including breast reconstruction, and for tendon,augmentation, ... and,muscle flap reinforcement indications. "SurgiMend has been ...
... to empower transplant patients ... and ... US,Inc. (Pink Sheets: ALPMF), a leader in the field of ... organization, announced a collaborative partnership to jointly,develop further materials for ...
Cached Biology Technology:Agencourt Genomic Services is Key Collaborator in New Research That Further Defines Landscape of Breast and Colon Cancers 2Agencourt Genomic Services is Key Collaborator in New Research That Further Defines Landscape of Breast and Colon Cancers 3TEI Biosciences Launches SurgiMend(TM) Collagen Matrix for Soft Tissue Reconstruction 2Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 2Astellas Pharma US, Inc. and The International Transplant Nurses Society (ITNS) Collaborate on Content for Transplant Experience Program 3
... Not treated (or medium binding) ... and binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ... can interact with the surface,• Binding ...
... optically clear polystyrene formulation , High antibody-binding ... , Plates are certified for performance ... , Eight-well strips fit snugly in ... in use even if turned upside down ...
... for in vitro diagnostic assays, all EIA/RIA ... for uniform binding, high optical clarity and ... are part of the Certified Surface Chemistry ... be within QA release specifications. Linkage: This ...
... adsorption and clarification reagent; Ideal for ... of antibodies, proteins, nucleic acids, & ... cross-reactivity, and improves downstream processing; Utilizes ... non-ionic adsorbent supplied as a suspension ...
Biology Products: