Navigation Links
Trichinosis parasite gets DNA decoded

Scientists have decoded the DNA of the parasitic worm that causes trichinosis, a disease linked to eating raw or undercooked pork or carnivorous wild game animals, such as bear and walrus.

After analyzing the genome, investigators at Washington University School of Medicine in St. Louis and their collaborators report they have identified unique features of the parasite, Trichinella spiralis, which provide potential targets for new drugs to fight the illness. The research is published online Feb. 20 in Nature Genetics.

While trichinosis is no longer a problem in the United States fewer than a dozen cases are reported annually an estimated 11 million people worldwide are infected. Current treatments are effective only if the disease is diagnosed early.

"It takes less than two weeks for the larvae to travel from the intestine to muscle, where they live," says lead author Makedonka Mitreva, PhD, research assistant professor of genetics at Washington University's Genome Center. "Once the worms invade the muscle, drugs are less effective. While the disease is rarely deadly, patients often live for months or years with chronic muscle pain and fatigue until the worms eventually die."

Today, trichinosis occurs most often in areas of Asia and Eastern Europe where pigs are sometimes fed raw meat, and meat inspections are lax.

The new research also has implications far beyond a single parasitic disease, the researchers say. T. spiralis is just one of many thousands of parasitic roundworms called nematodes that, according to the World Health Organization, infect 2 billion people worldwide, severely sickening 300 million. Other species of parasitic nematodes cause diseases in pets and livestock and billions of dollars of crop losses annually.

Among nematodes, T. spiralis diverged early, some 600-700 million years before the crown species, C. elegans, a model organism used in research laboratories. To date, the genomes of 10 nematodes, including five parasitic worms, have been decoded. The latest addition of the T. spiralis genome now allows scientists to compare species that span the phylum.

"T. spiralis occupies a strategic position in the evolutionary tree of nematodes, which helps fill in important knowledge gaps," explains senior author Richard K. Wilson, PhD, director of Washington University's Genome Center and professor of genetics. "By comparing nematode genomes, we have identified key molecular features that distinguish parasitic nematodes, raising the prospect that a single targeted drug may be effective against multiple species."

Over all, the genome of T. spiralis is smaller than that of C. elegans. It has 15,808 genes, compared to C. elegans' 20,000.

Moreover, about 45 percent of T. spiralis genes appear to be novel. These genes have not been found in other organisms and are not listed in public gene databases. The researchers say the worm's early evolutionary split or its distinctive lifestyle it can't survive outside the body may account for this extensive collection of enigmatic genes.

The researchers also found 274 families of proteins that are conserved among all nematodes and that do not exist in other organisms, including humans. Furthermore, they identified 64 protein families that are exclusive to parasitic nematodes.

"This provides opportunities for scientists to dig deeper into the distinctive features of parasitic nematodes that can be targeted with new drugs," Mitreva says. "If those drugs target molecular features unique to parasitic worms, it is more likely the side effects of those drugs will be minimal in humans."


Contact: Caroline Arbanas
Washington University School of Medicine

Related biology news :

1. NC State researchers get to root of parasite genome
2. Scripps Florida scientists awarded $1.5M to fight major water and food parasites
3. Parasite-resistant peppers green alternatives to chemical pesticides
4. Malaria parasite zeroes in on molecule to enhance its survival, team finds
5. Reduction in parasite infections ahead for India
6. Researchers identify new way the malaria parasite and red blood cells interact
7. Locking parasites in host cell could be new way to fight malaria
8. Mosquito parasite may help fight dengue fever
9. Immune genes adapt to parasites
10. Study finds role for parasites in evolution of sex
11. Discovery to aid in future treatments of third-world parasites
Post Your Comments:
Related Image:
Trichinosis parasite gets DNA decoded
(Date:9/24/2015)... NEW YORK , Sept. 24, 2015  EyeLock ... will be showcasing its award winning and latest technology ... Anaheim, California . EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA.   EyeLock,s platform uses video technology to deliver a ...
(Date:9/10/2015)... This report provides detailed descriptions of the ... emerging sensor types that will dominate in the future. ... the wearable technology hype curve in the last five ... feature with all of them is the prominence of ... useful functions. Sensors collect data about the physical and ...
(Date:9/10/2015)... Report Details The global wearable ... previous expectations of revenues, consumer adoption and even technological ... which wearables begin to achieve that mass market acceptance ... reasons is the entrance of Apple to the SmartWatches ... but the overall size of the wearable technology market. ...
Breaking Biology News(10 mins):
(Date:10/13/2015)... -- " Microbiology Culture Market - Global Industry ... " , the global microbiology culture market was valued ... bn by 2023, expanding at a CAGR of 5.9% during the ... Microbiology Culture Market - Global Industry Analysis, Size, Share, Growth, Trends, ... global microbiology culture market was valued at US$4.51 bn in 2014 ...
(Date:10/13/2015)... N.J. and SAN DIEGO ... and Mast Therapeutics, Inc. have agreed to collaborate in ... excipient-grade poloxamer 188 NF, marketed by BASF under the ... in a variety of pharmaceutical and biological applications, such ... 188 is the starting material for Mast,s lead product ...
(Date:10/13/2015)...  According to Kalorama Information, the global market ... by the end of 2015. Clinical laboratories are ... it is estimated that approximately 80% of physicians, ... addition to diagnosing patients, clinical lab testing may ... drug treatment and conditions, and determine individual therapy. ...
(Date:10/13/2015)... Sunnyvale, CA (PRWEB) , ... October 13, 2015 , ... ... adding key expertise to the company’s fast growing clinical data solutions business. , Jeff ... life science companies of all sizes, including Avery Dennison, Thermo Fisher, and Ab Sciex ...
Breaking Biology Technology: