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Trial combining anti-cancer drug and radiotherapy may lead to treatment for brain tumor
Date:9/30/2013

nts with glioblastoma deriving benefit from the new therapeutic strategy," Prof Wick will say. "At present, there is paucity of predictive markers that tell us how to treat patients in the glioma field."

Prof Wick and his colleagues are continuing their research: "We still need to improve our understanding of how APG101 is acting. We also envisage testing new combinations of APG101 and radiotherapy plus temozolomide, a chemotherapy drug used for treating glioblastoma. There is a need to explore the mode of action as well as the mode of acquired resistance to the compound in patients," he will conclude.

President of ECCO, Professor Cornelis van de Velde, commented: "Although these are preliminary results, they are very interesting because glioblastoma is such a fast-growing tumour and there are so few available treatment options for these patients. An improvement in the percentage of patients surviving for six months after being treated with the combination of radiotherapy and APG101 is significant. Furthermore, the discovery that CD95L is likely to be a predictive marker for patient response may help us to target treatments more effectively. The findings presented today are a further advance along the difficult path of finding a successful way to treat this aggressive cancer."


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Contact: José Abad
ecco2013press@gmail.com
ECCO-the European CanCer Organisation
Source:Eurekalert

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