Navigation Links
Trial combining anti-cancer drug and radiotherapy may lead to treatment for brain tumor
Date:9/30/2013

Results from a clinical trial of a new treatment for glioblastoma suggest that researchers may have found a new approach to treating this most aggressive of brain tumours, as well as a potential new biological marker than can predict the tumour's response to treatment.

Presenting the research to the 2013 European Cancer Congress (ECC2013) [1] today (Monday), Professor Wolfgang Wick will say that combining radiotherapy with an anti-cancer drug called APG101 a fusion protein similar to an antibody blocks a cell-signalling pathway called CD95 that plays a crucial role in the development of the cancer. "Blocking the CD95 system represents a new way of tackling glioblastoma a cancer that has few available treatment options," he will say.

A total of 84 glioblastoma patients, who had already received initial treatment including radiotherapy and whose cancer had recurred, were randomised in the phase II clinical trial to receive either radiotherapy alone, or radiotherapy together with an intravenous dose of 400 mg of APG101 once a week [2]. Their average age was 57, and the trial was carried out between December 2009 and September 2011 in 25 centres in Germany, Austria and Russia.

Twenty-one percent of patients who were treated with the combination of radiotherapy and APG101 were still alive six months after treatment, compared to four percent of those that were treated with radiotherapy alone. After two years, 22% of patients receiving the combination treatment were alive compared to seven percent of patients who did not receive it. The risk of death was reduced by 40% in the experimental treatment group, although this did not quite reach statistical significance.

Prof Wick, Chairman of the Neurooncology Programme at the National Centre for Tumour Diseases and Professor of Neurooncology at the University of Heidelberg (Germany) will tell the conference: "Glioblastoma is a very aggressive, fast-growing tumour that shows an infilt
'/>"/>

Contact: José Abad
ecco2013press@gmail.com
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
2. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
3. Canadian Journal of Cardiology publishes new atrial fibrillation guidelines
4. New clinical trial explores novel noninvasive colon cancer screening test
5. Clinical trial launches to see whether vitamin D helps treat multiple sclerosis
6. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
7. Trial launched into curry chemicals cancer-fighting properties
8. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
9. VolitionRX Raises Over $1 Million To Begin Clinical Trials of Blood Based Diagnostic Tests
10. Delivery of gene-therapy for heart disease boosted 100-fold; now in 100-patient trial
11. Clinical trials for Alzheimers disease preventative drug to begin early 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... points is a straight line, and now Harvard researchers ... axiom to heart. , Though competition among individual ... racing for the chance to fertilize the egg, Harvard ... that allow them to take a straighter path to ... Heidi Fisher, a post-doctoral student working in the lab ...
(Date:7/30/2014)... A group of researchers from the University of Helsinki ... experimentally to reproduce in mice morphological changes which have ... gradual modifications in the embryonic development of mice teeth, ... morphologically are very similar to those observed in the ... millions of years ago. , To modify the ...
(Date:7/30/2014)... Press (OUP) is pleased to announce its new relationship ... 2015, OUP and CINP will partner to publish ... a fully open-access journal. , Alan Frazer, Editor-in-Chief of ... size and expertise of OUP will further facilitate the ... of the very leading journals within neuropsychopharmacology. The conversion ...
Breaking Biology News(10 mins):When cooperation counts 2When cooperation counts 3Scientists reproduce evolutionary changes by manipulating embryonic development of mice 2OUP to partner with the International College of Neuropsychopharmacology 2
... CITY, Aug. 31, 2009 Researchers at Huntsman Cancer Institute ... on Ewing,s sarcoma, an often deadly bone cancer that typically ... with poor outcomes have tumors with high levels of a ... chemotherapy. The research is published online today in the journal ...
... its usefulness in counting copies of duplicated genome sequences and ... study to be published Aug. 30 in Nature Genetics ... differ from one person to the next. The researchers ... Search Tool. The study is titled, "Personalized Copy Number and ...
... on the neural mechanisms involved in social behavior, neuroscientists ... the brain structure responsible for our sense of personal ... 30 issue of the journal Nature Neuroscience , ... social distance is an issue. The structure, the ...
Cached Biology News:New hope for deadly childhood bone cancer 2Counting duplicated genome segments now possible 2Counting duplicated genome segments now possible 3Caltech neuroscientists find brain region responsible for our sense of personal space 2Caltech neuroscientists find brain region responsible for our sense of personal space 3Caltech neuroscientists find brain region responsible for our sense of personal space 4
(Date:7/31/2014)... Boston, MA (PRWEB) July 31, 2014 ... ) finds itself flush with innovative adult stem cell ... patents and has three additional patent applications ... Office. , The patented inventions address two of the ... and regenerative medicine. Adult stem cells are difficult ...
(Date:7/30/2014)... MD (PRWEB) July 30, 2014 ... today the release of the REVELERIS® Prep ... organic chemists, preparative chromatographers, and other researchers to ... using a single unit. , With the REVELERIS® ... flash and preparative chromatography modes with a simple ...
(Date:7/30/2014)... July 30, 2014  Replikins Ltd. today released new ... Ebola virus. Before the current outbreaks, the mean Ebola ... amino acids) between 1995 and 2002 was 1.1; the ... 2012, and sixteen-fold in 2013, thus predicting the current ... technology has been shown to be able to predict ...
(Date:7/30/2014)... 2014   Wyle has been named ... Mission Support Services (FILMSS) contract awarded by the ... terms of the contract, Wyle will provide mission ... Calif. In particular, Wyle will provide program and ... on the International Space Station and collaborative science ...
Breaking Biology Technology:The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 2The Adult Stem Cell Technology Center, LLC Launches A Marketing Campaign To License Adult Stem Cell Biotechnologies 3Grace Launches New REVELERIS® Prep Purification System 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2
... traditional August break, the Senate may help decide the future ... hope a scientifically sound and ethical resolution is reached - ... ,Just as Republicans in the Wisconsin Legislature are divided over ... President Bush suffered a rare political defeat in May when ...
... crazy? , ,Theres a question that every technology entrepreneur ... families, friends, employees, customers and, yes, investors. When youre ... that new-to-the-world and must-have tech breakthrough, your sanity will ... even more interesting than the question is how tech ...
... Waukesha, Wis. - ProHealth Care , a ... deployed an application delivery system from NetScaler, Inc. ... the system to better coordinate application usage and response ... and two regional hospitals, 13 primary care clinics, home ...
Cached Biology Technology:Stem cell debate in Washington grows hotter as summer recess nears 2Stem cell debate in Washington grows hotter as summer recess nears 3Psychologist - technology entrepreneurs frequently experience hypomania 2Psychologist - technology entrepreneurs frequently experience hypomania 3
...
... PlusOne Silver Staining Kit, Protein, 1. ... and Dernick (1), the kit gives ... electrophoresis systems.Silver Staining Kit, Protein provides ... proteins in polyacrylamide gels in less ...
Mouse monoclonal [IFR0104] to Salmonella enteriditis ( Abpromise for all tested applications)....
Cyno macaque plasma and serum - various quantities available...
Biology Products: