Navigation Links
'Treatments waiting to be discovered' inside new database
Date:8/5/2014

Your genes are blueprints for proteins, and molecules called microRNA can help to determine how often these genetic blueprints are manufactured into proteins. Researchers often ask what microRNA regulates a gene related to disease. Or what gene is regulated by a microRNA found in sick patients? The answers to these questions could help doctors and researchers manipulate protein levels in the body that cause disease, especially cancer. A University of Colorado Cancer Center study recently published in the top-ranked journal Nucleic Acids Research (NAR) describes a database named multiMiR, the most comprehensive database collecting information about microRNAs and their targets.

"You can't imagine the tangled web of data that describes the cause and effect relationships of microRNAs and genes. This multiMiR database will let researchers search efficiently through these relationships for pairings relevant to the diseases they study," says Katerina Kechris, PhD, associate professor of Biostatistics and Informatics at the University of Colorado Denver, and one of the study's senior authors.

In addition to assisting researchers search for relationships between microRNAs and their genetic targets, the database includes drugs known to affect these microRNAs and also lists diseases associated with microRNAs.

"Right now, within this database, investigators can find clues to potential new treatments for various diseases including cancer," says Dan Theodorescu, MD, PhD, professor of Surgery and Pharmacology at the CU School of Medicine, director of the University of Colorado Cancer Center and one of the study's senior authors.

The project includes nearly 50 million records representing the combination of 14 previously existing microRNA data repositories. The multiMiR database also links to previous research results relevant to these microRNAs. multiMiR combines this functionality within the leading open-source statistical software, R, allowing for increased flexibility for analysis and accessibility by data analysts everywhere.

Basically, researchers can input names of microRNAs, genes, drugs, diseases or any combination thereof. Then the researcher can ask the database for validated or predicted genetic targets of microRNAs, or for validated/predicted microRNAs that regulate specific genes. Similar is true of diseases and drugs informatics tools show which diseases are associated with microRNAs and which (if any) drugs have been linked to a specific miRNA queried.

Case studies described in the article show how microRNAs may affect voluntary alcohol consumption in mice, candidate genes within signaling pathways associated with chronic obstructive pulmonary disease, and the microRNA:gene interactions that influence bladder cancer.

"We need data and then we need clever ways to look at it otherwise we drown in the wealth of information," Theodorescu says. "This new tool will allow us to ask new questions of more data with greater precision and get better, more insightful results that will ultimately help develop new approaches for patient treatment."


'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
University of Colorado Denver
Source:Eurekalert

Related biology news :

1. Step forward in research into new treatments for brain edema
2. Marshall University study may lead to new treatments for prostate cancer
3. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
4. Scripps Florida scientists awarded $8.4 million grant to develop new anti-smoking treatments
5. Discovery of mechanisms predicting response to new treatments in colon cancer
6. Manipulating chromatin loops to regulate genes may offer future treatments for blood diseases
7. Reorganizing brain could lead to new stroke, tinnitus treatments
8. Purple corn compound may aid in developing future treatments for Type 2 diabetes, kidney disease
9. ALS TDI and Gladstone Institutes collaborate to discover potential ALS treatments
10. Penn team mimicking a natural defense against malaria to develop new treatments
11. Petri dish lens gives hope for new eye treatments
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/9/2016)... an innovation leader in attendance control systems is proud to announce the introduction of ... make sure the right employees are actually signing in, and to even control the ... ... ... ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
(Date:6/2/2016)... 2016 The Department of Transport Management ... 44 million US Dollar project, for the , ... Personalization, Enrolment, and IT Infrastructure , to ... and implementation of Identity Management Solutions. Numerous renowned international vendors ... Decatur was selected for the most compliant and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Mosio, a ... eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced clinical research ... by providing practical tips, tools, and strategies for clinical researchers. , “The landscape ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... June 23, 2016 A person commits a crime, ... scene to track the criminal down. An outbreak ... and Drug Administration (FDA) uses DNA evidence to track down ... Sound far-fetched? It,s not. The FDA has increasingly used ... investigations of foodborne illnesses. Put as simply as possible, whole ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: