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Treatment for extreme nausea, vomiting during pregnancy
Date:5/6/2009

rate compared to women who received no medication. As expected, metoclopramide was not associated with other serious side effects.

"This study validates our protocol," says Dr. Brard. "Clinical trials are not conducted on pregnant women, so we had to rely on data from prospective and retrospective studies in this case. We anticipate that other institutions will now be comfortable adopting this new treatment regime.

About hyperemis gravidarum

Hyperemis gravidarum, or severe nausea and vomiting of pregnancy, affects about one percent of pregnant women. If left untreated, it can result in severe weight loss, dehydration, or death. Symptoms to look out for include severe vomiting and nausea; incapacity to keep food down for two to three days; lack of energy.

According to Dr. Brard, women should not wait too long before seeking medical help. "The longer the symptoms continue, the longer the hospital stay," she says, adding most women with HG leave the hospital within three days and many are required to take medication throughout their pregnancy.

About the study:

"Metoclopramide and diphenhydramine in the treatment of hyperemisis gravidarum: Effectiveness and predictors of rehospitalization," published in European Journal of Obstetrics and Gynecology and Reproductive Biology, was authored by Anais Lacasse, Ema Ferreira and Anick Brard of the Universit de Montral and the Sainte-Justine University Hospital Centre and Amandine Lagoutte of the Universit de Bourgogne.


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Contact: Sylvain-Jacques Desjardins
sylvain-jacques.desjardins@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

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