Navigation Links
Treatment for deadly yeast disease reduced to 3 days
Date:4/24/2014

Initial treatment for a brain infection caused by fungus could now be treated in three days, rather than two weeks, due to study by University of Liverpool scientists.

Cryptococcus a form of yeast - infections are often fatal but are relatively neglected in medical research. They are found in many parts of the world, including Africa, Australasia and South East Asia and mainly affect people with weakened immune systems. This infection kills up to 700,000 people a year.

The University research team has tested the effects of the most commonly used drug on Cryptococcus infections of the brain and discovered that although the recommendation for treatment is currently two weeks, the drug has been shown by the new studies to be effective at clearing the fungus within three days.

Professor of Therapeutics and Infectious Diseases, William Hope said: "This infection kills up to 700,000 people a year and is mainly fatal in areas with poor resources. In many parts of the world it is simply infeasible to administer intravenous drugs for two weeks."

The scientists in the Institute of Translational Medicine examined the effects of amphotericin B deoxycholate (dAmB) over both three and 14 day treatments and found that the effect was the same after three days as it was after two weeks.

The results in animal trials was compared with humans using a range of mathematical modelling techniques, to produce findings which suggest that the three day regime will be equally as effective in people.

The researchers believe that this opens up significant possibilities for treatment in areas where there is a scarcity of medically trained staff, who often have to ration the drugs they administer to patients.

The infection often takes hold in people with AIDS as a result of their immune systems being compromised, and areas with high rates of AIDS are also usually those without resources.

Professor Hope added: "A lot of the treatment administered with a variety of drugs is assumed and generalised. This is one example of how experimental medicine can help accelerate changes to improve outcomes for patients."

The next stage of the research will be to test it in clinical trials in humans. The findings were published in the journal mBio.


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Genetic research develops tools for studying diseases, improving regenerative treatment
4. Step forward in research into new treatments for brain edema
5. Marshall University study may lead to new treatments for prostate cancer
6. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
7. Minimally invasive treatment for ruptured aneurysm: Safe, reduces mortality
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
10. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
11. Antipsychotic drug may be helpful treatment for anorexia nervosa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... , Feb. 3, 2016 Vigilant Solutions ... Police Department in Missouri solved ... plate reader (LPR) data from Vigilant Solutions. ... case in which the victim was walking out of a convenience store and ... space next to his vehicle, striking his vehicle and ...
(Date:2/2/2016)... Feb. 2, 2016 Technology Enhancements Accelerate Growth of ... of the digital and computed radiography markets in ... and Indonesia (TIM). It provides ... size, as well as regional market drivers and restraints. ... market penetration and market attractiveness, both for digital and ...
(Date:2/1/2016)... ( www.wocketwallet.com ) announces the launch of a new video featuring singer, ... Las Vegas , where Joey appeared at the Wocket booth to ... , where Joey appeared at the Wocket booth to meet and greet ... the Consumer Electronics Show (CES2016) in Las Vegas , ... --> --> The video is ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... 2016  Neurocrine Biosciences, Inc. (NASDAQ: NBIX ) today announced ... 2015. --> --> For ... of $29.3 million, or $0.34 loss per share, compared to a ... the same period in 2014. For the year ended December 31, ... $1.05 loss per share, as compared to a net loss of ...
(Date:2/11/2016)... , Feb. 11, 2016  Wellcentive today ... Portland, Oregon -based community care ... provide population health analytics, quality reporting and care ... FamilyCare strengthen its team of quality managers, analysts ... to the provider groups serving FamilyCare members. ...
(Date:2/11/2016)... York (PRWEB) , ... February 11, 2016 , ... ... instruments for more than 150 years, continues today to pursue the highest level ... line of analytical instruments: the AR9 Refractometer and the AR5 Refractometer. Accurate, ...
(Date:2/10/2016)... , Feb. 10, 2016  The Maryland House of ... has announced that University of Maryland School of Medicine ... and University of Maryland Medical System President and CEO ... "Speaker,s Medallion," the highest honor given to the public ... Dean Reece and Mr. Chrencik for ...
Breaking Biology Technology: