Navigation Links
Treatment for deadly yeast disease reduced to 3 days
Date:4/24/2014

Initial treatment for a brain infection caused by fungus could now be treated in three days, rather than two weeks, due to study by University of Liverpool scientists.

Cryptococcus a form of yeast - infections are often fatal but are relatively neglected in medical research. They are found in many parts of the world, including Africa, Australasia and South East Asia and mainly affect people with weakened immune systems. This infection kills up to 700,000 people a year.

The University research team has tested the effects of the most commonly used drug on Cryptococcus infections of the brain and discovered that although the recommendation for treatment is currently two weeks, the drug has been shown by the new studies to be effective at clearing the fungus within three days.

Professor of Therapeutics and Infectious Diseases, William Hope said: "This infection kills up to 700,000 people a year and is mainly fatal in areas with poor resources. In many parts of the world it is simply infeasible to administer intravenous drugs for two weeks."

The scientists in the Institute of Translational Medicine examined the effects of amphotericin B deoxycholate (dAmB) over both three and 14 day treatments and found that the effect was the same after three days as it was after two weeks.

The results in animal trials was compared with humans using a range of mathematical modelling techniques, to produce findings which suggest that the three day regime will be equally as effective in people.

The researchers believe that this opens up significant possibilities for treatment in areas where there is a scarcity of medically trained staff, who often have to ration the drugs they administer to patients.

The infection often takes hold in people with AIDS as a result of their immune systems being compromised, and areas with high rates of AIDS are also usually those without resources.

Professor Hope added: "A lot of the treatment administered with a variety of drugs is assumed and generalised. This is one example of how experimental medicine can help accelerate changes to improve outcomes for patients."

The next stage of the research will be to test it in clinical trials in humans. The findings were published in the journal mBio.


'/>"/>

Contact: Jamie Brown
jamie.brown@liverpool.ac.uk
44-151-794-2248
University of Liverpool
Source:Eurekalert

Related biology news :

1. Breakthroughs in Chikungunya research from A*STAR spell new hope for better treatment and protection
2. Collaborative preclinical efficacy studies suggest a new target for drug addiction treatment
3. Genetic research develops tools for studying diseases, improving regenerative treatment
4. Step forward in research into new treatments for brain edema
5. Marshall University study may lead to new treatments for prostate cancer
6. New discoveries about brain-hand connection sought to improve therapies, treatments, prosthetics
7. Minimally invasive treatment for ruptured aneurysm: Safe, reduces mortality
8. Penn research points to new way of preserving fertility for boys undergoing cancer treatment
9. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
10. New discovery may lead to effective prevention and treatment of graft-versus-host dsease
11. Antipsychotic drug may be helpful treatment for anorexia nervosa
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/3/2018)... ... October 03, 2018 , ... Fit4D, a leading ... of healthcare visionary, Jimmy Lee, as Strategic Advisor to the company’s board. Mr. ... industry experience. As a Senior Executive at Anthem, he had P&L accountability for ...
(Date:10/2/2018)... ... 2018 , ... The Federal Identity Forum & Exposition (FedID ... The Palo Alto-based face recognition company, Camvi Technologies Inc., was invited to speak ... U.S. Federal executives from Department of Defense (DoD) and Federal Bureau of Investigation ...
(Date:10/1/2018)... ... October 01, 2018 , ... ... customers and InteloMed, the leading patient monitoring technology providing real-time information on individual ... other indications of patient health during a telehealth visit without the use of ...
Breaking Biology News(10 mins):
(Date:9/28/2018)... (PRWEB) , ... September 28, 2018 , ... ... virtual events for tech innovators, engineers, and scientists from around the world, is ... the National University of San Marcos, as the winner of the LabRoots Summer ...
(Date:9/27/2018)... ... 2018 , ... Nvision Biomedical Technologies , a San ... at the North American Spine Society (NASS) Annual Meeting, held at the Los ... System, which received clearance from the U.S. Food and Drug Administration (FDA) in ...
(Date:9/22/2018)... ... September 20, 2018 , ... ... announce a strategic venture. The synergistic combination of Predicine’s GeneRADAR molecular insights ... comprehensive biomarker profiling to empower clinical trials in the immuno-oncology (IO) space. ...
(Date:9/15/2018)... ... , ... Nationally recognized public accounting and consulting firm Cherry Bekaert LLP ... Firm’s Nashville practice, on her appointment to Launch Tennessee’s Board of Directors. ... Partner of the Firm’s Nashville practice in December 2017 . In this role, she ...
Breaking Biology Technology: