Navigation Links
Treatment corrects severe insulin imbalance in animal studies
Date:7/31/2008

osing such lesions and performing the curative surgery on newborns.

However, when abnormal cells are distributed throughout the pancreas in so-called diffuse HI, surgeons must remove nearly all the pancreas. This relieves HI in about a quarter of cases, but leaves the majority of patients at high risk for insulin imbalance, in which blood glucose levels are too low (hypoglycemia) or too high, resulting in diabetes.

The new study makes use of a peptide (an amino acid compound) called exendin-(9-39) that blocks the action of a specific hormone receptor in beta cells. Building on their previous work using exendin-(9-39) on normal mice, De Len's study team studied the peptide's effect on a strain of mice that had been genetically engineered to mimic the defect found in children with congenital HI.

When researchers withhold food from those mice, their blood glucose levels become low, a condition called fasting hypoglycemia. Mice who had received exendin-(9-39), however, had significantly higher levels of fasting blood glucose compared to mice that were not treated with the peptide, and reached levels comparable to those in normal, healthy animals. Further studies identified the mechanisms in the hormone signaling system that malfunctions in HI.

The next step, says De Len, is a pilot study now under way to test the effect of exendin-(9-39) in children and adults with congenital HI. If results from the pilot study are promising, her study team expects to progress to a larger clinical trial. "If this peptide can be developed into a treatment for children with this common form of HI, we may have a new tool for controlling their insulin levels and managing their disease," added De Len.

The Congenital Hyperinsulinism Center at Children's Hospital has worldwide prominence in diagnosing and treating this genetic disease. Much of its work builds on pioneering research by Charles A. Stanley, M.D., in identifying the specific gene defec
'/>"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6050
Children's Hospital of Philadelphia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Video released of rapid Alzheimers improvement after new immune-based treatment
2. Fertility treatment in developing countries; a cycle of IVF for less than $200
3. New treatment approach promising for lymphoma patients in the developing world
4. Treatment delays result in poor outcomes for men with breast cancer
5. Counting tumor cells in blood predicts treatment benefit in prostate cancer
6. Stroke study reveals key target for improving treatment and suggests that Gleevec may help
7. Hypertension treatment effective in reversing vascular damage
8. Rong Li Lab identifies new role of inflammatory protein in PKD and a possible treatment
9. Source of drug-tolerant tuberculosis possibly behind TB relapses, intensity of treatment
10. Novel therapeutic strategy for colon cancer treatment
11. New ballast treatment could protect Great Lakes fish
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/3/2014)... Researchers from Australia report that low birth weight and ... (OA)-related hip replacements in adulthood. Findings published in the ... & Research , indicate that low birth weight and ... arthroplasty due to OA as adults. , According ... of 25 are diagnosed with clinical OA. Symptoms of ...
(Date:11/2/2014)... was fascinating to put a flashlight up to our ... Washington University in St. Louis engineers are using a ... to improve imaging of cancerous tissues and to develop ... K. Beare Distinguished Professor of Biomedical Engineering at the ... novel time-reversal technology that allows researchers to better focus ...
(Date:10/31/2014)... Brazil was the world,s largest producer of cocoa. Chocolate ... 800, 000 ha region of rainforest in the state ... trees. Whereas the surrounding rainforest was a biodiversity hotspot, ... handful of seeds introduced in the mid 1700s, had ... scientist Gonçalo Pereira, "This scenario created a very romantic, ...
Breaking Biology News(10 mins):Preterm, low birth-weight babies may need new hips in adulthood 2Improving imaging of cancerous tissues by reversing time 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 3
... Product Development, teaming with,Ball Aerospace & Technologies Corp., ... a new thermal insulation. NASA has awarded,the team ... to develop and,commercialize this advanced thermal insulation., ... and exploration missions would preserve rocket fuels such ...
... Dr. Marie-Jolle Rochet, a research scientist at IFREMER (The ... been awarded the prestigious Pew Fellowship in Marine Conservation ... least harmful to the delicately balanced marine ecosystem. She ... encourage widespread use of that technique, and to further ...
... the Integrated Ocean Drilling Programs Nankai Trough Seismogenic ... Kii Peninsula today. The expedition science party, 26 ... 19, 2007, aboard the drilling vessel Chikyu, to ... of the Nankai Trough fault zone. The expedition ...
Cached Biology News:Colorado Engineering Firms Win NASA Grant to Develop Innovative Insulation for Next Generation Spacecraft - Super-Insulation May Allow Future Energy Efficient Appliances 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 22008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 32008 Pew Fellowship in Marine Conservation awarded to Dr. Marie-Joëlle Rochet from IFREMER 4Scientists obtain core samples from subsea fault system off Japan 2
(Date:11/16/2014)... The “Fluid Management & Visualization Systems Market”, ... with an analysis and forecast of value by ... warming and waste management. Along with this, the ... by applications and regions are also discussed in ... $19,285.5 million in 2013 and is expected to ...
(Date:11/15/2014)... The International Society for ... the society’s Governing Board has grown with the ... scientific officer and Dr. Charles Simonton, divisional vice ... Mr. Rowe and Dr. Simonton are both ... , Dr. Nabil Dib, ISCTR President stated, ...
(Date:11/15/2014)... November 14, 2014 New photonics entrepreneurs ... Startup Challenge 2015 , an opportunity to pitch their ... experts and venture capitalists. The annual competition is held ... Center in San Francisco, running 7-12 February and hosted ... photonics . , Cash prizes, including $10,000 for first ...
(Date:11/15/2014)... -- F. David Rollo , MD, Ph.D., FACC, FACNP ... Professional in the field of Medicine as a result ... Cell Point is a privately held biotechnology ... , Houston and ... ethylenedicysteine drug conjugate technology ("EC Technology"), In-Situ Hydrogel ("In ...
Breaking Biology Technology:Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 2Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 3Fluid Visualization Systems Market poised to reach $25,908.4 Million by 2018 - New Research Report by MarketsandMarkets 4International Society for Cardiovascular Translational Research Governing Board Adds Medical Industry Leaders 2New Photonics Entrepreneurs Need to Apply Now for SPIE Startup Challenge 2015 2New Photonics Entrepreneurs Need to Apply Now for SPIE Startup Challenge 2015 3F. David Rollo, MD, Ph.D., FACC, FACNP is recognized by Continental Who's Who as a Pinnacle Professional 2
... better predict general patterns of evolution, a University of ... surprising things about gene mutations that might one day ... disease. UH evolutionary biologist Timothy Cooper and ... "Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial ...
... WESTBROOK, Maine, June 2, 2011 IDEXX Laboratories, Inc. (NASDAQ: ... in the William Blair & Company 31st Annual Growth Stock ... a presentation on the Company on Tuesday, June 14, 2011 ... Chicago, Illinois. Individuals can access the live audio webcast of ...
... Morphotek®, Inc., a subsidiary of Eisai Inc., announced today ... of MORAb-004 for the treatment of metastatic melanoma. The ... that specifically binds to endosialin/tumor endothelial marker-1 (TEM-1), as ... activity at two dosages. The trial is ...
Cached Biology Technology:Work by UH evolutionary biologist may one day help with chronic diseases 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3