Navigation Links
Treating neonatal meningitis -- is nitric oxide a foe or a friend to bacteria?
Date:2/24/2010

Los Angeles, CA Current research suggests that nitric oxide may play a role in the pathogenesis of neonatal meningitis. The related report by Mittal et al, "Inhibition of inducible nitric oxide controls pathogen load and brain damage by enhancing phagocytosis of Escherichia coli K1 in neonatal meningitis," appears in the March 2010 issue of The American Journal of Pathology.

Bacterial meningitis, or inflammation of the membranes that cover the brain and spinal cord, is often fatal, even when treated with antibiotics. In neonates, mortality occurs in 25 to 35% of all patients, and long-term neurological and psychological effects are reported in up to 50% of survivors. One of the most common causes of neonatal meningitis is a serotype of Escherichia coli that expresses the capsular antigen K1, which is similar in structure to proteins expressed in the brain.

Nitric oxide plays a key role in the pathogenesis of meningitis; however, it remains unclear whether it plays a pro- or anti-microbial role. To determine the role of inducible nitric oxide synthase (iNOS), responsible for the production of nitric oxide, in meningitis, a group led by Dr. Nemani Prasadarao of the Childrens Hospital Los Angeles examined the effects of E. coli K1 infection in brains of neonatal mice. They found that E. coli K1 infection induced nitric oxide due to the activation of iNOS and that mice deficient in iNOS were resistant to E. coli infection. In addition, treatment with the iNOS-specific inhibitor aminoguanidine cleared the pathogen from circulation and prevented brain damage, likely via increased uptake and killing of bacteria by immune cells. Therefore iNOS inhibition may provide a new therapeutic strategy for treating neonatal E. coli-induced meningitis.

Mittal et al conclude that "further understanding of the complex interactions between E. coli K1 and macrophages are important to the ide
'/>"/>

Contact: Angela Colmone, Ph.D.
acolmone@asip.org
301-634-7953
American Journal of Pathology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scripps research team reveals how an old drug could have a new use for treating river blindness
2. Findings show nanomedicine promising for treating spinal cord injuries
3. Research shows treating HIV-AIDS with interleukin-2 is ineffective
4. Treating even mild gestational diabetes reduces birth complications
5. The vasculature emerges as a potential therapeutic target in treating ADPKD liver cysts
6. Treating bone loss in breast cancer survivors
7. Single host gene may hold key to treating both ebola and anthrax infections
8. Test helps in fight against lung infections and for treating other life-threatening infections
9. Glutamine supplements show promise in treating stomach ulcers
10. New hope for advances in treating malaria
11. Cold and brown fat raise the prospect of a new method of treating obesity
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... Munich report that a new class of chemical ... drugs. They have also pinpointed the relevant target ... agents. , Researchers led by LMU,s Professor ... Technische Universitt Mnchen have identified a class of ... the fight against malignant tumors. The compound is ...
(Date:9/30/2014)... , Sept. 30, 2014  Spectra ... solutions for the biotech and power generation ... new RECONN Bioprocess Manager, an easy-to-use and ... geared towards bioprocess development laboratories. ... disparate bioreactor and analyzer systems. Accessing and ...
(Date:9/29/2014)... Clostridium ramosum , coupled with a high-fat diet, may cause ... in mBio , the online open-access journal of the ... the German Institute of Human Nutrition Potsdam-Rehbruecke in Nuthetal observed ... gained weight when fed a high-fat diet. Mice that ... even when consuming a high-fat diet, and mice that had ...
Breaking Biology News(10 mins):Cancer therapy: Driving cancer cells to suicide 2Spectra Automation Introduces RECONN Bioprocess Manager 2Gut bacteria promote obesity in mice 2
... Bethesda, MD FASEB MARC (Maximizing Access to ... recipients for the American Association of Immunologists 2013 ... from July 13-18, 2013. These awards are meant ... scientists from underrepresented groups into the mainstream of ...
... progress in the search for the first broad-spectrum drugs ... common infectious diseases. Their study on these potential drugs ... the journal ACS Medicinal Chemistry Letters . ... HRV infections cause mild disease, they can lead to ...
... teachers to sing melodies accurately, according to a new ... the University of Kaiserslautern in Germany. Their analysis of ... songbirds, brain processes. The work is published online in ... is considered to be one of the most complex ...
Cached Biology News:Songbirds turn on and tune up 2
(Date:9/30/2014)... 2014 Whitehouse Laboratories is ... the Parenteral Drug Association (PDA) to host ... on container closure integrity testing. This lecture/laboratory course will ... and philosophies detailed in the recently proposed revision to ... The course will span container closure integrity testing (leak ...
(Date:9/29/2014)... 30, 2014 Each year in ... require medical attention. In the military, burn injury ... to battlefield medical care. More than 800 service ... Burn wounds heal slowly, remain inflamed and often ... physically debilitating and functionally damaging. While developments in ...
(Date:9/29/2014)... , Sept. 29, 2014  Ten of the ... of cartilage repair, regeneration, allograft reconstruction and research ... the world gathered to discuss the future of ... of Regenerative Medicine symposium, Cartilage Regeneration: State ... included Orthopedic Biosurgery, Minced Juvenile Allograft, and State ...
(Date:9/29/2014)... emerging diseases and biodiversity loss requires evolutionary thinking, ... Science Express that was co-authored by Bruce ... Agriculture and Life Sciences. , For the first ... reviewed progress in addressing a broad set of ... approaches that consider evolutionary histories and the likelihood ...
Breaking Biology Technology:Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 2Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 3Whitehouse Laboratories to Partner with PDA for Educational Course on Container Closure Integrity Testing 4Faster Healing with Fewer Scars 2World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3Evolutionary biology: It's not just for textbooks anymore 2Evolutionary biology: It's not just for textbooks anymore 3
... Kansas to its annual promotional campaign of biotechnological, pharmaceutical and medical device companies ... , , (Logo:   ... (Logo:   http://www.newscom.com/cgi-bin/prnh/20040907/CLTU006LOGO ) , ... The leading employment Web site for the life sciences launched the ...
... July 29 Omeros Corporation (Nasdaq: OMER ) ... facility under which it may sell up to $40 ... Opportunity, Ltd. (the "investor") over a 24-month period. Omeros is ... enter into and consummate other equity, debt and non-dilutive financing ...
... ,, LONDON , ... pleased,to announce the appointment of Dr Neill Moray Mackenzie ... to CMPT a long record of executive,board level management ... Genetics Ltd, Oxford Biomedica plc (an LSE,listed company), Avidex ...
Cached Biology Technology:BioSpace Showcases the Midwest's Growing Life Science Region 2BioSpace Showcases the Midwest's Growing Life Science Region 3Omeros Secures $40 Million Committed Equity Financing Facility 2Omeros Secures $40 Million Committed Equity Financing Facility 3Omeros Secures $40 Million Committed Equity Financing Facility 4CMP Therapeutics Appoints Dr Neill Moray Mackenzie as CEO 2CMP Therapeutics Appoints Dr Neill Moray Mackenzie as CEO 3CMP Therapeutics Appoints Dr Neill Moray Mackenzie as CEO 4CMP Therapeutics Appoints Dr Neill Moray Mackenzie as CEO 5
Recombinant Feline IFN-alpha...
Anti-OSMR Monoclonal Antibody Research Focus: cytokine/growth factor Storage: 4C Shipping Temperature: 4C...
Rabbit polyclonal to Presenilin 1, prediluted ( Abpromise for all tested applications). entrezGeneID: 5663 SwissProtID: P49768...
ROCK-1 (cleaved) Monoclonal Ab 100 ug purified mouse monoclonal antibody. Clone# 12M03. Reacts with human. Tested in Western blot analysis....
Biology Products: