Navigation Links
Traumatizing your DNA
Date:3/23/2011

Tel Aviv When the Human Genome Project ended a decade ago, scientists thought that they'd closed the lid on all that's to be known about our genes. But what they really did was open a Pandora's Box, says theoretical evolutionary biologist Prof. Eva Jablonka of Tel Aviv University's Cohn Institute for the History and Philosophy of Science and Ideas.

After sifting through hundreds of scientific studies concerned with epigenetics, Prof. Jablonka concludes that some of the effects of stress, cancer, and other chronic diseases we suffer from may be passed on to our offspring through deep and complicated underlying cellular mechanisms that we are just now beginning to understand.

Prof. Jablonka will discuss her findings at an epigenetics conference in North Carolina later this month.

The invisible threat

Epigenetic research suggests that the effects of stress and environmental pollution can be passed on to future generations without any obvious change or mutation in our DNA. The problem, Prof. Jablonka points out, is that we have no idea of the extent these effects will have on the human genome of the future.

"I am a story teller. I read a lot of information and develop theories about evolution. For the last 25 years, before it became a fad, I was interested in the transmission of information not dependent on DNA variations," Dr. Jablonka says. "Epigenetic inheritance is information about us that is not explicitly encoded in our genes. Two individuals may have identical genes, but the genes present very different characteristics. They can be genetically identical but different epigenetically."

In a 2009 paper for the Quarterly Review of Biology, Prof. Jablonka wrote about cellular epigenetic inheritance and explored some of the consequences of such inheritance for the study of evolution, also pointing to the importance of recognizing and understanding epigenetic inheritance for practical and theoretical issues in biology. She has since concluded that individuals can influence their heredity.

After reviewing the literature, she has found more than 100 examples of living organisms, from bacteria to human beings, demonstrating how our genes' expression can be altered and inherited.

"Stress is enormously important," Prof. Jablonka says. "It can affect the development of cancer and other chronic diseases, and may also have long term impacts on ecology." At the conclusion of the Human Genome Project, researchers hoped that the findings would provide relief from several diseases. "What they weren't prepared for," she continues, "is that genes really do so many things, and that gene expression patterns can be heritable. We can learn some things about diseases from our DNA, but it doesn't tell the whole story."

Is environmental pollution irreversible?

Stress can create near invisible effects on gene expression, effects that can be passed from mother or father to child. Some of this operates through microRNA, tiny RNA discovered about a decade ago which work as cellular "micro-managers." In addition, a process called DNA methylation alters gene function. Various processes "hidden" in chromosomes within the cells appear to be influenced by lifestyle and disease.

As a result, Prof. Jablonka advises that it might be prudent to reconsider all the environmental pollutants being introduced into the planet's ecosystems. Some pesticides and fungicides are androgen suppressors and have many effects on gene expression and these effects can be inherited. Whether and how future generations can endure with these altered gene functions are still open questions, she says.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Traumatizing your DNA
(Date:6/22/2016)... , June 22, 2016   Acuant ... and verification solutions, has partnered with RightCrowd ... solutions for Visitor Management, Self-Service Kiosks and ... products that add functional enhancements to existing ... corporations and venues with an automated ID ...
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/7/2016)...  Syngrafii Inc. and San Antonio Credit Union ... integrating Syngrafii,s patented LongPen™ eSignature "Wet" solution into ... result in greater convenience for SACU members and ... existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/23/2016)...  Blueprint Bio, a company dedicated to identifying, protecting ... has closed its Series A funding round, according to ... "We have received a commitment from Forentis Fund that ... meet our current goals," stated Matthew Nunez . ... complete validation on the current projects in our pipeline, ...
(Date:6/23/2016)... 2016 On Wednesday, June 22, 2016, ... 0.22%; the Dow Jones Industrial Average edged 0.27% lower to ... down 0.17%. Stock-Callers.com has initiated coverage on the following equities: ... (NASDAQ: NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ... BIND ). Learn more about these stocks by accessing their ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... quality, regulatory and technical consulting, provides a free webinar on Performing ... July 13, 2016 at 12pm CT at no charge. , Incomplete investigations are ...
(Date:6/23/2016)... June 22, 2016  Amgen (NASDAQ: AMGN ... QB3@953 life sciences incubator to accelerate the ... shared laboratory space at QB3@953 was created to help ... obstacle for many early stage organizations - access to ... sponsorship, Amgen launched two "Amgen Golden Ticket" awards, providing ...
Breaking Biology Technology: