Navigation Links
Trauma drama: K-State professor researches drama queen of immune system
Date:8/8/2011

MANHATTAN, KAN. -- Kansas State University's Sherry Fleming is investigating the factor that initiates the immune system's "drama queen": the one responsible for intestinal cell damage after hemorrhage.

Fleming, an associate professor in the Division of Biology, is using a $140,000 grant from the American Heart Association to identify the molecule responsible for the overreaction that can cause cell death in the intestines after trauma.

"What's starting this drama queen situation? A 13-year-old girl doesn't usually become a drama queen without a reason. There's something that initiated the drama -- clothes, shoes, make-up, movies, etc.," Fleming said. "With hemorrhage, we're looking for the initiating factor in the drama which occurs after trauma."

After a traumatic event, such as the loss of a limb or severe bleeding, the body cuts off blood flow to the intestines, sending more blood to the vital organs like the heart, lungs and brain, Fleming said. During that time, cells in the gut release molecular markers to let the body know that they are not getting oxygen.

After the trauma is resolved, blood flow is returned to the gut and a protein in the blood -- known as beta2 glycoprotein 1 in mice and apolipoprotein H in humans -- binds to the molecular marker on the cell to notify antibodies that there is a problem. The antibodies then activate a cascade of proteins, known as complement, that normally help the immune system by killing bacteria and helping rid tissues of dying cells. However, after a trauma this system can overreact and unnecessarily kill healthy cells.

"If you've been in a car accident and sever an arm or start hemorrhaging, you want complement there to protect you from bacteria. So we don't want to stop all complement action entirely," Fleming said.

But Fleming is looking for a way to interrupt the chain of events leading to the over activation of complement following a traumatic event, because trauma patients often develop further complications throughout their body due to the activation of complement, she said.

"Many times trauma patients who have lost a lot of blood will end up with acute respiratory distress syndrome or multiple organ dysfunction syndrome, due to the complement system overreacting," Fleming said. "So they not only have to deal with the trauma, but also with their immune system attacking things that it shouldn't."

As a possible solution, Fleming and her lab group have developed a peptide that takes the place of the beta2 protein in binding to the molecular marker on the cell's surface, thus preventing the activation of complement.

"This treatment is a promising solution," Fleming said. "The funding from the American Heart Association will give us the opportunity to make major progress in this research."


'/>"/>

Contact: Sherry Fleming
sdflemin@k-state.edu
785-532-6130
Kansas State University
Source:Eurekalert

Related biology news :

1. Risk factors predictive of psychiatric symptoms after traumatic brain injury
2. Can traumatic memories be erased?
3. Cephalopods experience massive acoustic trauma from noise pollution in the oceans
4. Traumatizing your DNA
5. UTHealth studies cord blood stem cells for pediatric traumatic brain injury
6. Drug prevents post-traumatic stress syndrome
7. Sangart, Inc. Announces Cooperative Research and Development Agreement With the U.S. Navy to Evaluate MP4 Molecule in Traumatic Brain Injury
8. Study provides treatment hope for long term effects of brain trauma
9. Boston Univ., Veterans Affairs find sports brain trauma may cause disease mimicking ALS
10. Post-traumatic stress disorder diagnosed with magnetism
11. New study finds way to stop excessive bone growth following trauma or surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/20/2017)... 20, 2017 At this year,s CeBIT Chancellor Dr. ... manufacturer DERMALOG. The Chancellor came to the DERMALOG stand together with the ... year,s CeBIT partner country. At the largest German biometrics company the two ... face and iris recognition as well as DERMALOGĀ“s multi-biometrics system.   ... ...
(Date:3/13/2017)... , March 13, 2017 Future of security: Biometric ... ... DERMALOGs Face Matching enables to match face pictures ... the basis to identify individuals. (PRNewsFoto/Dermalog Identification Systems) ... DERMALOG,s "Face Matching" is the fastest software for biometric Face ...
(Date:3/7/2017)... Brandwatch , the leading social intelligence company, today announces that ... uncover insights to support its reporting, help direct future campaigns, and ... youth charity will be using Brandwatch Analytics social listening and analytics ... of the topics and issues that are a priority for its ... "Until recently ...
Breaking Biology News(10 mins):
(Date:3/23/2017)... 2017 NetworkNewsWire Editorial Coverage  ... Cancer remains one ... on health care systems, in terms of costs and resources. ... does the development of innovative and efficient therapies that demonstrate ... many types of cancer treatments, a growing number of patients ...
(Date:3/22/2017)... TARRYTOWN, N.Y. , March 22, 2017 Regeneron ... among the Regeneron Genetics Center (RGC), U.K. Biobank and GSK ... in the U.K. Biobank resource. The initiative will enable researchers ... of new medicines for a wide range of serious and ... ...
(Date:3/22/2017)... , March 22, 2017 Oramed Pharmaceuticals ... www.oramed.com ), a clinical-stage ... drug delivery systems, announced today that Dr. ... deliver a presentation titled, "Oral Insulin for Diabetes ... Cambridge Healthtech Institute,s Oligonucleotide and Peptide Therapeutics (OPT) Boston Conference ...
(Date:3/22/2017)... --  Boston Biomedical , an industry leader in the ... stemness pathways, today announced its Board of Directors has ... Officer, effective April 24, 2017. Ms. ... FACP, who has led Boston Biomedical since he founded ... Biomedical has grown from a "garage startup" without technology ...
Breaking Biology Technology: