The philosophy of this monograph is to apply an interdisciplinary approach and thus outline the latest advances in such areas as absorption mechanisms of nutrients (sugars, amino acids, dipeptides) and membrane digestion in the small intestine of vertebrates.
State-of-the art concepts and the understanding of epithelial transport phenomena are covered based on the results obtained by the author in the course of his own lifetime research, carried out predominantly in the laboratories headed by the late Prof. A. Ugolev, as well as on data from other researchers.
The novel updates to the known electrophysiological short-circuit current techniques employed allow for discussing the newest evidence concerning the molecular mechanisms of transport, such as the maximum rate and the affinity of the transporters for a nutrient. Some other topics touched upon concern the roles played by unstirred layers of liquid near the membrane surface, the transport of water and the mechanisms of osmotic phenomena, as well as transport processes control. The validity of the methods developed is illustrated by an analysis of absorption under satiety conditions as compared to fasting conditions and absorption in young and old rats. The probable prospects of applying this biophysical method described to clinical investigations are best demonstrated using specific examples.
Praise for this book:
"This book is devoted to a comprehensive consideration of the molecular transport mechanism of various substances (nutrients, water, ions etc.) through the enterocyte brush border membrane of the small intestine. In fact this goes beyond the existing monographs dwelling on the physiology of absorption and digestion. Detailed and extensive
studies performed by the author have served to significantly expand and refine our understanding of the problems considered in the book, thus building an effective link between physiology and a clinical study of digestion."
Professor O. Gazenko (R.I.P.), former President of the Russian Physiological Society
"Publication of this book devoted to pioneer research has made apparent that S. Metelsky, a disciple of A. Ugolev, is now a leading expert on the physiology of digestion and absorption, and in the physiology of nutrition all over the Former Soviet Union. I believe his monograph will render a big impact not only on gastroenterology and physiology, but also on other sciences."
V. Ivashkin, President of the Russian Gastroenterological Association
"Due to his thorough and scrupulous theoretical and experimental analysis. S. Metelsky manages to transform the known electrophysiological techniques of Ussing into a modern powerful and novel research method that will probably gain popularity and become widely used. It is precisely this research that has led to a better understanding of transport processes pathology in intestinal mucosa."
Professor A. Kubatiev, President of the Russian Pathophysiological Society.
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