"HGF plays an essential role in tissue regeneration and angiogenesis and acts as a potent antifibrotic agent," explained Kim.
The researchers concluded that local injection, rather than systemic intravenous injection, was preferred because systemic injection caused the hMSCs to be localized in the pulmonary capillary bed.
Voiding function was assessed at four weeks post-transplantation and MRI "showed clear hypointense signal induced by the labeled cells". When the bladders of the transplanted group were harvested they were found to have improved smooth muscle cells and reduced collagen deposition.
The researchers concluded that MSC-based cell transplantation may be a novel therapeutic strategy for bladder dysfunction in patients with SCI.
"This study provides potential evidence that an human stable immortalized MSC line could be useful in the treatment of spinal cord injury-related problems such as bladder dysfunction." said Dr. David Eve, associate editor of Cell Transplantation and Instructor at the Center of Excellence for Aging & Brain Repair at the University of South Florida. "Further studies to elucidate the mechanisms of action and the long term effects of the cells, as well as confirm the optimal route of administration, will help to illuminate what the true benefit of these cells could be."
|Contact: Robert Miranda|
Cell Transplantation Center of Excellence for Aging and Brain Repair