Navigation Links
Transplanted neural stem cells slows als onset and progression in mouse models
Date:12/19/2012

WORCESTER, MA Promising new research provides evidence that ALS, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be treatable using neural stem cells. A consortium of researchers at multiple institutions, including the University of Massachusetts Medical School, Sanford-Burnham Medical Research Institute and Brigham and Women's Hospital, have shown that neural stem cells, when transplanted into the spinal cord of a mouse model with familial ALS, slow disease onset and progression while improving motor function, breathing and survival time compared to untreated mice. A summary of the studies was published online in Science Translational Medicine.

ALS is a progressive, neurodegenerative disorder affecting the motor neurons in the central nervous system. As motor neurons die, the brain's ability to send signals to the body's muscles is compromised. This leads to loss of voluntary muscle movement, paralysis and eventually respiratory failure. The cause of most cases of ALS is not known.

Approximately 10 percent of cases are inherited. Though investigators at UMass Medical School and elsewhere have identified several genes shown to cause inherited or familial ALS, almost 50 percent of these cases have an unknown genetic cause.

Neural stem cells are the precursors of all brain cells. They can self-renew, making more neural stem cells, and differentiate, becoming nerve cells or other brain cells. These cells can also rescue malfunctioning nerve cells and help preserve and regenerate brain tissue. But they've never before been studied extensively in a good model of adult ALS.

In 11 independent studies, the group, headed by Dr. Evan Snyder of the Burnham Institute, transplanted neural stem cells into the spinal cord of a mouse model of ALS. The transplanted neural stem cells benefited the mice with ALS by preserving the health and function of the remaining nerve cells.

Specifically, the neural stem cells promoted the production of protective molecules that spared remaining nerve cells from destruction. They also reduced inflammation and suppressed the number of toxin-producing and disease-causing cells in the host's spinal cord.

"It is striking that the stem cells improve motor neuron viability without generating new motor neurons. These findings encourage us to explore further the role of cell therapies in ALS," said Robert Brown, MD, DPhil, a co-author on the study and chair of neurology at UMass Medical School. A leading expert in ALS, Dr. Brown led the team that discovered the first gene linked to familial ALS, a protein anti-oxidant known as superoxide dismutase, or SOD1 in 1993.


'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Related biology news :

1. New cranial neural crest cell line developed
2. New neural pathway controlling skeletal development discovered
3. Astrocytes control the generation of new neurons from neural stem cells
4. Novel microscopy method offers sharper view of brains neural network
5. Color-coded markers may help doctors diagnose neural diseases through the eyes
6. Transgenic technique to eliminate a specific neural circuit of the brain in primates
7. Manipulation of a specific neural circuit buried in complicated brain networks in primates
8. Cracking the Neural Code: Third Annual Aspen Brain Forum
9. Neural stem cell transplants for spinal cord injury maximized by combined, complimentary therapies
10. Scientists find neural stem cell regulator
11. Protein creates paths for growing nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... Report Highlights The global biosurgery ... billion in 2016 at a compound annual growth rate ... Includes - An overview of the global market for ... from 2015 and 2016, and projections of compound annual ... market on the basis of product type, source, application, ...
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a ... a new white paper " What You Should Know ... problem of ensuring user authenticity is a growing concern. ... authentication of users. However, traditional authentication schemes such as ... Biometric authentication offers an elegant solution to ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... Scientists propose in Nature blocking ... Gaucher and maybe other lysosomal storage diseases as a ... current therapies. An international research team led ... also included investigators from the University of Lübeck in ... 22. The study was conducted in mouse models of ...
(Date:2/22/2017)... ... February 22, 2017 , ... ProMIS Neurosciences (“ProMIS” or ... neurodegenerative diseases, today announced it has issued a scientific white paper entitled “Results ... a series of commentaries from ProMIS’s scientific team offering insight into the Company’s ...
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots , the leading provider of ... world, is pleased to announce the launch of a new scholarship for young scientists ... , This merit-based scholarship is open to all high school seniors, 17 years or ...
(Date:2/22/2017)... 22, 2017 Origin (Origin Agritech, LLC, a subsidiary of ... provider, and Arcadia (Arcadia Biosciences, Inc., NASDAQ: ... commercializes agricultural productivity traits and nutritional products, today announced their collaboration ... developed in China to the ... ...
Breaking Biology Technology: