Navigation Links
Transplanted neural stem cells slows als onset and progression in mouse models
Date:12/19/2012

WORCESTER, MA Promising new research provides evidence that ALS, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, may be treatable using neural stem cells. A consortium of researchers at multiple institutions, including the University of Massachusetts Medical School, Sanford-Burnham Medical Research Institute and Brigham and Women's Hospital, have shown that neural stem cells, when transplanted into the spinal cord of a mouse model with familial ALS, slow disease onset and progression while improving motor function, breathing and survival time compared to untreated mice. A summary of the studies was published online in Science Translational Medicine.

ALS is a progressive, neurodegenerative disorder affecting the motor neurons in the central nervous system. As motor neurons die, the brain's ability to send signals to the body's muscles is compromised. This leads to loss of voluntary muscle movement, paralysis and eventually respiratory failure. The cause of most cases of ALS is not known.

Approximately 10 percent of cases are inherited. Though investigators at UMass Medical School and elsewhere have identified several genes shown to cause inherited or familial ALS, almost 50 percent of these cases have an unknown genetic cause.

Neural stem cells are the precursors of all brain cells. They can self-renew, making more neural stem cells, and differentiate, becoming nerve cells or other brain cells. These cells can also rescue malfunctioning nerve cells and help preserve and regenerate brain tissue. But they've never before been studied extensively in a good model of adult ALS.

In 11 independent studies, the group, headed by Dr. Evan Snyder of the Burnham Institute, transplanted neural stem cells into the spinal cord of a mouse model of ALS. The transplanted neural stem cells benefited the mice with ALS by preserving the health and function of the remaining nerve cells.

Specifically, the
'/>"/>

Contact: Jim Fessenden
james.fessenden@umassmed.edu
508-856-2000
University of Massachusetts Medical School
Source:Eurekalert

Page: 1 2

Related biology news :

1. New cranial neural crest cell line developed
2. New neural pathway controlling skeletal development discovered
3. Astrocytes control the generation of new neurons from neural stem cells
4. Novel microscopy method offers sharper view of brains neural network
5. Color-coded markers may help doctors diagnose neural diseases through the eyes
6. Transgenic technique to eliminate a specific neural circuit of the brain in primates
7. Manipulation of a specific neural circuit buried in complicated brain networks in primates
8. Cracking the Neural Code: Third Annual Aspen Brain Forum
9. Neural stem cell transplants for spinal cord injury maximized by combined, complimentary therapies
10. Scientists find neural stem cell regulator
11. Protein creates paths for growing nerve cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Aug. 21, 2014 Nxt-ID, Inc. (OTCQB: NXTD), ... commerce market, announced today that its shares of common ... be issued in its proposed underwritten public offering of ... on The Nasdaq Capital Market, subject to closing of ... and warrants, and will trade under the symbol "NXTD" ...
(Date:8/21/2014)... ubiquitous skin fungus linked to dandruff, eczema and other ... to even further global reachesincluding Hawaiian coral reefs and ... vents. , A review in the scientific journal ... of the fungi of the genus Malassezia ... sequencing datasets from around the world. , University of ...
(Date:8/21/2014)... -- Nine researchers from Beth Israel Deaconess ... in "The World,s Most Influential Scientific Minds 2014," ... Thomson Reuters ScienceWatch, a web resource for science metrics ... recognized as among the most influential "are performing and ... the advancement of their science," according to a Thomson ...
Breaking Biology News(10 mins):Nxt-ID Approved for NASDAQ Capital Market Listing 2Nxt-ID Approved for NASDAQ Capital Market Listing 3From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3
... commercially available mineral waters, the researchers found evidence of ... the water. What,s more, these chemicals are potent in ... in the New Zealand mud snail. These findings, which ... of plastic food packaging materials act as functional estrogens, ...
... diseases that can travel with the wind have the ... understood, according to a new study, in findings that ... but also a new fungus that threatens global wheat ... State University and other institutions, concluded that invading diseases ...
... is available in Spanish . , ... of psychosis and schizophrenia, and those episodes of psychosis ... characteristics, both before their appearance and in the clinical ... conclusions of the doctoral thesis "Neurodevelopment and environmental stress ...
Cached Biology News:Hormone-mimics in plastic water bottles -- just the tip of the iceberg? 2New wheat disease could spread faster than expected 2New wheat disease could spread faster than expected 3Daily consumption of cannabis predisposes to the appearance of psychosis and schizophrenia 2
(Date:8/21/2014)... YORK , Aug. 21, 2014 Mathematic studies ... Harvard University , and funded by the Jeffrey ... cells within tumors can be visually identified for elimination. These ... growth. The study, which shows a topological map of what ... time in cancer research, for while tumor cells can be ...
(Date:8/21/2014)...  China Cord Blood Corporation (NYSE: CO ... financial results for the first quarter of fiscal year ... in the US.  The Company will ... Friday, August 29, 2014 to discuss its financial performance ... developments, followed by a question and answer session.  Interested ...
(Date:8/21/2014)... Pursuit Solutions ( http://www.pursuit-solutions.com ), ... services for Life Sciences sales and marketing organizations, ... New Commercial Sales Models” by Peter Robinson, co-founder ... article examines some innovative models used to improve ... in the pharmaceutical market. Robinson grades the industry ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... biopharmaceutical contract development and manufacturing organization (CMO) announced ... Pharmaceuticals, Inc., an oncology company focused on the ... cancer, to manufacture the anti-prostate specific membrane antigen ... product candidate. Under the agreement the antibody ...
Breaking Biology Technology:Science Power Jeffrey Epstein and Harvard University Fund Project to Visually Stop Tumor Growth 2China Cord Blood Corporation to Report First Quarter of Fiscal 2015 Financial Results 2Pursuit's Peter Robinson Publishes "Grading Pharma's Use of New Commercial Sales Models" 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3
... of decorative, flower-like defects in the nanomaterial graphene could ... electrical and mechanical properties, according to researchers at the ... Tech. In a new paper,* the team for the ... could occur naturally or be induced to occur in ...
... of the March 11 earthquake and rolling blackouts that ... award-winning undergraduate internship program NanoJapan is scrambling to run ... U.S. undergraduates travel to Japan for lab internships, NanoJapan ... send 25-30 students to Rice University laboratories for three ...
... May 25, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ... the treatment of hepatitis C, announced today that it will ... the Company,s oral immuno-modulator that acts via the TLR-7 pathway, ... Meeting in Chicago, IL.  The data from the completed Phase ...
Cached Biology Technology:Defect in graphene may present bouquet of possibilities 2Reverse NanoJapan: Rice to host 25-30 Japanese students 2Anadys Highlights ANA773 Data to be Presented at ASCO 2Anadys Highlights ANA773 Data to be Presented at ASCO 3Anadys Highlights ANA773 Data to be Presented at ASCO 4
... The CHEMICON APO-BRDU Kit is ... labeling DNA breaks and total cellular DNA ... The kit contains the instructions and ... including; positive and negative control cells for ...
... overlay agarose, is a low melting point ... to secure IPG strips in place for ... incorporated to allow monitoring of electrophoresis runs. ... melting point agarose in 1x Tris, glycine, ...
... cell is an apparatus dedicated to general ... agarose slab gels. The cell includes the ... tray, 5 glass plates, 50 sheets of ... templates, and instructions. Dimensions are 21 x ...
... range of next-generation features into a small-footprint ... for flexible laboratory solutions. It puts every ... dilution, dispensing, and integrations into a ... flexible as it is efficient and economical. ...
Biology Products: