Navigation Links
Transplanted fat cells restore function after spinal cord injury
Date:12/10/2008

Tampa, Fla. (Dec. 10, 2008) A study published in the current issue of CELL TRANSPLANTATION (Vol.17, No. 8) suggests that mature adipocytes - fat cells - could become a source for cell replacement therapy to treat central nervous system disorders.

According to the study's lead researcher, Dr. Yuki Ohta of the Institute of Medical Science, St. Mariana University School of Medicine, Kawasaki, Japan, adipose-derived stem/stromal cells have in the past been shown to differentiate into neuronal cells in an in vitro setting. In their study, for the first time fat cells have been shown to successfully differentiate into neuronal cells in in vivo tests. The fat cells are grown under culture conditions that result in them becoming de-differentiated fat (DFAT) cells.

"These cells, called DFAT cells, are plentiful and can be easily obtained from adipose tissue without discomfort and represent autologous (same patient) tissue," said Ohta. "DFAT cells, with none of the features of adipocytes, do have the potential to differentiate into endothelial, neuronal or glial lineages."

The research team reported that DFAT cells expressed neurotrophic factors, such as BDNF and GDNF, prior to and after transplantation and which likely contributed to the promotion of functional recovery.

According to Ohta and colleagues, tests in animal models confirmed that the injected cells survived without the aid of immunosuppression drugs and that the DFAT-grafted animals showed significantly better motor function than controls.

"We concluded that DFAT-derived neurotrophic factors contributed to promotion of functional recovery after spinal cord injury (SCI)," said Ohta. "Transplanting DFAT cells into SCI rats significantly promoted the recovery of their hind limb function."

"These studies demonstrate the ability to obtain stem cells from a patient's own fat that can help repair injury to the spinal cord," said Paul R. Sanberg, PhD, DSc, at the University o
'/>"/>

Contact: Yuki Ohta
yuki-o@marianna-u.ac.jp
81-449-778-111
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

Page: 1 2

Related biology news :

1. ESF EURYI award winner aims to stop cancer cells reading their own DNA
2. Newly created cancer stem cells could aid breast cancer research
3. AIDS interferes with stem cells in the brain
4. Clemson scientists shed light on molecules in living cells
5. Social habits of cells may hold key to fighting diseases
6. UF scientists reveal how dietary restriction cleans cells
7. Human derived stem cells can repair rat hearts damaged by heart attack
8. Scientists identify embryonic stem cells by appearance alone
9. Cells united against cancer
10. Pittsburgh scientists identify human source of stem cells with potential to repair muscle
11. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/23/2015)... Mar. 23, 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ... the growing mobile commerce market, announces its biometric payment technology, ... on CNBC television starting March 30 th . ... in New York markets. ... are excited about our new ad campaign following the recent ...
(Date:3/20/2015)... , Mar. 19, 2015 Research and Markets ... "Iris Biometrics - Global Strategic Business Report" report ... markets for Iris Biometrics in US$ Thousands. The report provides ... , Japan , Europe ... , and Latin America . ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 2NXT-ID's Wocket Smart Wallet to Launch New CNBC Regional TV Ad Campaign 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... for manipulating macromolecules has been developed by researchers at ... double-stranded DNA to direct the behavior of other molecules. ... been used as a static lattice to construct geometrical ... into such shapes, the researchers are using DNA to ...
... bacterium that can cause respiratory tract infections, which can ... It is therefore important to develop a vaccine against ... advance of print publication of the May issue of ... from Cornell University use a novel strategy to create ...
... Investigators from the University California, San Diego (UCSD) Branch ... NimbleGen Systems have developed an efficient method to identify ... to a study published today in Nature. , Genes ... product. Thus the 'promoter' - a DNA sequence that ...
Cached Biology News:DNA constraints control structure of attached macromolecules 2Whole genome promoter mapping - Human Genome Project v2.0? 2
(Date:4/16/2015)... According to the 2014 Liberty Mutual ... was ranked first among the leading causes of ... pushing, pulling, holding, carrying, or throwing and cost ... Round Company takes statistics like this very seriously. ... develop and design equipment that prevents these injuries ...
(Date:4/16/2015)... , April 16, 2015 /PRNewswire/ - Portage Biotech ... Canadian Securities Exchange: PBT.U), is pleased to announce that ... Show on April 25, 2015 to be held in ... Gregory Bailey and Mr. James Mellon ... and an update on the key programs at its ...
(Date:4/16/2015)... A new infographic compiles useful information ... institutions to learn how Appleā€™s new framework can change ... is ideal since Apple made Research Kit ... open-source framework for developing medical research apps that Apple ... researchers to collect secure clinical data and communicate via ...
(Date:4/16/2015)... , April 16, 2015  EMD Serono today ... Darmstadt, Germany , appointed ... Head of Global Clinical Development.  Dr. Reicin brings ... experience in Oncology and Immunology. She is an ... served as a Vice President in various capacities ...
Breaking Biology Technology:The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3
... , ... Group,("Simcere" or the "Company") (NYSE: SCR ), ... marketing of branded,generic and proprietary pharmaceuticals in China, today ... China,s National Drug Reimbursement List,("NDRL"), which was issued by ...
... The ... camera fourth among the publication’s “Top 10 Innovations of 2009. , ... (PRWEB) December 2, 2009 -- The ... of high-performance CCD and EMCCD cameras for the life sciences, was ranked fourth among ...
... 1 PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) ... 31, 2009 of approximately $57 million, as compared with $69 ... quarter 2008 results was the first of two installment payments ... quarter 2008 results was a one-time $1.8 million payment from ...
Cached Biology Technology:Simcere Announces 105 Drugs Included in China's National Drug Reimbursement List 2Simcere Announces 105 Drugs Included in China's National Drug Reimbursement List 3The Scientist Names Photometrics' Evolve EMCCD Camera One of the “Top 10 Innovations” of 2009 2The Scientist Names Photometrics' Evolve EMCCD Camera One of the “Top 10 Innovations” of 2009 3PDL BioPharma Provides Fourth Quarter 2009 Revenue Guidance of Approximately $57 Million 2PDL BioPharma Provides Fourth Quarter 2009 Revenue Guidance of Approximately $57 Million 3
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
Sprague Dawley rats, 7-8 weeks of age, mixed gender; collected by exsanguination in Alsever's solution at 1:2 dilution...
... of BAC (100+kb), fosmid (40kb), and large ... than any othe BAC vector. On command ... and easy recombinant DNA purification. Available with ... VC) vectors for the highest insert stability. ...
... cloning of BAC (100+kb), fosmid (40kb), and ... stability than any othe BAC vector. On ... yields and easy recombinant DNA purification. Available ... (pSMART VC) vectors for the highest insert ...
Biology Products: