Ventricular ejection fraction measures the percentage of blood pumped from the heart at each contraction and is one of the most important measures of how the heart functions, Yeh said. LVEF normally is around 55 to 60 percent. Some cancer chemotherapies weaken the heart. "Oncologists pay very close attention to the ejection fraction in their patients, because when it drops, they won't give chemotherapy," Yeh said.
Multiple imaging methods pinpoint location, performance of transplanted stem cells
Developing and refining non-invasive monitoring of the heart is important for cancer patients, said senior co-author Juri Gelovani, M.D., Ph.D., professor and chair of MD Anderson's Department of Experimental Diagnostic Imaging.
"We need to develop methods for non-invasive monitoring by molecular-genetic and functional imaging of the fate of transplanted stem cells as they contribute regeneration of cardiac tissues and recovery of the heart's contractile function" Gelovani said. "We want to give the gift of sight to an otherwise very blind area of stem cell transplantation research."
After tying off an artery to the heart to induce a heart attack in the mice, the team then injected the mouse CD34+ cells around the damaged area in the treatment cohort. Before injection, a triple-fusion reporter gene was introduced via retrovirus into the CD34+ cells. The triple-fusion reporter allows for visualization of the stem cells using three different imaging methods after
|Contact: Scott Merville|
University of Texas M. D. Anderson Cancer Center