Navigation Links
Transplanted adult stem cells provide lasting help to injured hearts
Date:5/7/2010

HOUSTON Human adult stem cells injected around the damage caused by a heart attack survived in the heart and improved its pumping efficiency for a year in a mouse model, researchers at The University of Texas MD Anderson Cancer Center report online ahead of publication in Circulation Research.

The study, with researchers at the Texas Heart Institute at St. Luke's Episcopal Hospital, used innovative imaging techniques developed by researchers at MD Anderson to track the stem cells' location and performance over time.

Injection of a patient's own adult stem cells into the heart has shown some efficacy in assisting recovery after a heart attack in early human clinical trials, said study senior author Edward T. H. Yeh, M.D., professor and chair of MD Anderson's Department of Cardiology.

"But nobody knows how they work, or how long the stem cells last and function in the heart," Yeh said. "This study shows how one type of adult stem cell works."

The team's research focused on adult stem cells those that can differentiate into a limited variety of tissues that circulate in the blood and are distinguished by the presence of the CD34 protein on the cell surface. These CD34-positive cells usually differentiate into blood vessel cells, also known as endothelial cells.

Earlier research by Yeh and colleagues showed CD34+ cells are capable of becoming heart muscle cells, called cardiomyocytes, blood vessel cells and smooth muscle cells.

A series of experiments showed:

  • The CD34+ cells survived in the left ventricle of the heart for 12 months or longer.

  • Left ventricular ejection fraction a measure of how much blood is pumped from the heart to other organs at each contraction improved in treated mice compared with controls for 52 weeks. LVEF went from 50 percent at baseline to 37 percent after heart attack and treatment, compared with 51 percent and 28 percent in untreated mice.

    <
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Transplanted fat cells restore function after spinal cord injury
2. Studies on imaging and tracking transplanted cells
3. Device protects transplanted pancreatic cells from the immune system
4. New period of brain plasticity created with transplanted embryonic cells
5. Meth exposure in young adults leads to long-term behavioral consequences
6. Deep into the machinery of adult fragile X
7. Adult brain can change, study confirms
8. For migrating sparrows, kids have a compass, but adults have the map
9. New book defines promising young field of adult neurogenesis
10. Young chimps top adult humans in numerical memory
11. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
(Date:7/9/2015)... , July 9, 2015  Synaptics ... developer of human interface solutions, today announced ... industry,s first fully hardware encapsulated fingerprint sensor ... authentication technology is literally off the grid, ... biometric matching within the fingerprint sensor to ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
Breaking Biology News(10 mins):Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 2Synaptics Announces World's First Match-in-Sensor Fingerprint Authentication Technology 3BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... In a study of adults aged 20 and ... acid are at much higher levels in individuals who have ... levels than in individuals who are also vitamin B12 deficient ... methylmalonic acid, compounds used by enzymes that contain vitamin B12, ...
... pass genes to the next generation. In sexually reproducing ... are vital for fertility. In a new study published ... at Cornell University knocked down the levels of 25 ... males abilities to modulate egg production, sperm storage and ...
... to remain through reporting of 2007 fiscal year, ... (Nasdaq:,AWRE), a leading supplier of broadband technology and ... the position of Chief,Financial Officer beginning in February ... 1996 until September 2003., Keith Farris, Aware,s ...
Cached Biology News:Vitamin B-12 function may be diminished by excessive folate 2Aware, Inc. Announces Richard Moberg to Return as CFO 2Aware, Inc. Announces Richard Moberg to Return as CFO 3
(Date:8/3/2015)... -- According to a new market report ... Asia to Witness Highest Growth by ... culture market was valued at US$ 586.1 Mn in 2014 ... 29.1% to account for US$ 2,717.6 Mn by 2020. ... 3D cell culture refers to a process ...
(Date:7/31/2015)... LAS VEGAS , July 31, 2015 /PRNewswire/ ... pharmacists seek resources that help them drive positive ... as a vital source of patient care in ... Pharmacy,s annual tradeshow and conference, AmerisourceBergen announced ... strengthen its Pharmacy Services Administration Organization and help ...
(Date:7/31/2015)... ... July 31, 2015 , ... R-Biopharm ... quantification of partially hydrolyzed gluten in foods, has been accepted by AOAC International ... “Partially Hydrolyzed Gluten in Fermented Cereal-Based Products by R5 Competitive ELISA,” based on ...
(Date:7/30/2015)... Mass. , July 30, 2015   ... solutions for the interpretation and analysis of genomic ... Matthew Fischer has joined the company as ... Photo - http://photos.prnewswire.com/prnh/20150730/250931 ... capabilities to integrate, interpret, analyze and explore complex ...
Breaking Biology Technology:Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 2Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 3Global 3D Cell Culture Market Will Reach US$ 2,717.6 Million by 2020: Persistence Market Research 4AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3RIDASCREEN® Competitve Gliadin Receives AOAC Official First Action Status 2GenoSpace Introduces Matthew Fischer as Vice President of Sales and Marketing 2
... ... in a dynamic and unpredictable world at Wharton Leadership Conference. , ... Philadelphia, PA (Vocus) June 16, 2009 -- As the ... is well-positioned to deliver dynamic innovations to meet the evolving markets demand because “change is ...
... , PHILADELPHIA, June 16 The Pew Charitable Trusts ... Fellows in the Biomedical Sciences. The rigorously competitive program provides ... with leading researchers in the United States. Upon returning to ... equipment to continue their research in their home countries. ...
... SHANGHAI, June 16 /PRNewswire-Asia/ -- WuXi PharmaTech ... Edward Hu, the Company,s Chief Operating Officer and,acting Chief ... Conference in New York on Wednesday, June 17, 2009, ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ) , ...
Cached Biology Technology:Leading for Growth in the New Economic Reality Includes Vision and Innovation 2Leading for Growth in the New Economic Reality Includes Vision and Innovation 3Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 2Ten Top Latin American Scientists Named 2009 Pew Fellows in the Biomedical Sciences 3