Navigation Links
Transplanted adult stem cells provide lasting help to injured hearts
Date:5/7/2010

HOUSTON Human adult stem cells injected around the damage caused by a heart attack survived in the heart and improved its pumping efficiency for a year in a mouse model, researchers at The University of Texas MD Anderson Cancer Center report online ahead of publication in Circulation Research.

The study, with researchers at the Texas Heart Institute at St. Luke's Episcopal Hospital, used innovative imaging techniques developed by researchers at MD Anderson to track the stem cells' location and performance over time.

Injection of a patient's own adult stem cells into the heart has shown some efficacy in assisting recovery after a heart attack in early human clinical trials, said study senior author Edward T. H. Yeh, M.D., professor and chair of MD Anderson's Department of Cardiology.

"But nobody knows how they work, or how long the stem cells last and function in the heart," Yeh said. "This study shows how one type of adult stem cell works."

The team's research focused on adult stem cells those that can differentiate into a limited variety of tissues that circulate in the blood and are distinguished by the presence of the CD34 protein on the cell surface. These CD34-positive cells usually differentiate into blood vessel cells, also known as endothelial cells.

Earlier research by Yeh and colleagues showed CD34+ cells are capable of becoming heart muscle cells, called cardiomyocytes, blood vessel cells and smooth muscle cells.

A series of experiments showed:

  • The CD34+ cells survived in the left ventricle of the heart for 12 months or longer.

  • Left ventricular ejection fraction a measure of how much blood is pumped from the heart to other organs at each contraction improved in treated mice compared with controls for 52 weeks. LVEF went from 50 percent at baseline to 37 percent after heart attack and treatment, compared with 51 percent and 28 percent in untreated mice.

    <
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Transplanted fat cells restore function after spinal cord injury
2. Studies on imaging and tracking transplanted cells
3. Device protects transplanted pancreatic cells from the immune system
4. New period of brain plasticity created with transplanted embryonic cells
5. Meth exposure in young adults leads to long-term behavioral consequences
6. Deep into the machinery of adult fragile X
7. Adult brain can change, study confirms
8. For migrating sparrows, kids have a compass, but adults have the map
9. New book defines promising young field of adult neurogenesis
10. Young chimps top adult humans in numerical memory
11. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... of the Tibetan plateau -- the largest topographic anomaly ... both its profound effect on climate and its reflection ... GSA Bulletin , Katharine Huntington and colleagues employ a ... modern and fossil snail shells to investigate the uplift ... , Views range widely on the timing of surface ...
(Date:8/28/2014)... America (ESA) is pleased to announce the selection of ... Society. Honorary Membership acknowledges those who have served ESA ... the affairs of the Society that has reached an ... the ESA Governing Board and then voted on by ... the Awards Ceremony at Entomology 2014, ESA,s Annual Meeting ...
(Date:8/28/2014)... reports that an expansion of marine protected areas is ... functions. According to investigators from the Wildlife Conservation ... have focused on saving the largest numbers of species, ... key and difficult-to-replace ecological functions. , Many ... fish species that also are food for millions of ...
Breaking Biology News(10 mins):Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... Howard Hughes Medical Institute (HHMI) scientists has peeled back some ... off genes selectively to control critical events of development. The ... the structure of Dicer, an enzyme that enables cells to ... in the January 13, 2005, issue of the journal Science ...
... Biobank, a visionary medical project aimed at improving the ... and many other serious conditions is launched this week ... three thousand people living in the south Manchester area ... before it goes nationwide later this year. , They ...
... at the University of Minnesota Medical School have discovered a ... have properties of primitive stem cells. , Umbilical ... that can only produce cells found in blood. The ... cells with the characteristics of more primitive stem cells that ...
Cached Biology News:Molecule does more than slice and dice RNA 2Molecule does more than slice and dice RNA 3Molecule does more than slice and dice RNA 4Multi-million pound UK Biobank underway 2Multi-million pound UK Biobank underway 3
(Date:8/29/2014)... DIEGO, Aug. 29, 2014  Pfenex Inc. (NYSE ... the development of high-value and difficult to manufacture ... update and reported financial results for the second ... the successful completion of our initial public offering, ... our biosimilar product candidates, derived from our proprietary ...
(Date:8/29/2014)... of the most promising technologies for future quantum circuits ... instead of electrons. First, it is necessary to be ... control their direction. Researchers around the world have made ... now scientists at the Niels Bohr Institute have succeeded ... at a time and in a particular direction. The ...
(Date:8/29/2014)... New York (PRWEB) August 29, 2014 ... valued at $5.6 billion in 2019. It is ... from 2013 to 2019, and was valued at ... report published by Transparency Market Research. , For ... visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research report, ...
(Date:8/29/2014)... According to a new market report published by Transparency ... valued at USD 3,754.6 million in 2012 and is estimated ... CAGR of 5.9% from 2013 to 2019. , Nearly half ... by bone and joint disorders, and this number is expected ... will continue to increase the demand for orthobiologics. Other factors ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Breakthrough in light sources for new quantum technology 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... breath, sweat and skin have been used to detect humans ... of portable sensors for use in real-life situations, such as ... disasters in New Zealand and Japan. Published today, Monday ... , the study examined flumes of air to create a ...
... , Bochum,s physicists led by Prof. Dr. Hartmut Zabel ... for the first time experimentally. The behaviour of the ... research team at the RUB has now succeeded in ... resolution. Through their rotation of the magnetic moments, the ...
... Ore. -- A collaborative Oregon State University-University of Oregon ... Science Foundation grant in 2008, is moving into a ... The new NSF funding, awarded through its Centers ... Sustainable Materials Chemistry to expand research and development and ...
Cached Biology Technology:Scientists utilize breath and sweat to detect trapped humans 2Spin pumping effect proven for the first time 2Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 2Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 3Center for Sustainable Materials Chemistry gets Phase 2 NSF grant 4
Request Info...
... the 4300 System features Saga GT , ... SagaGT automates electrophoresis, lane finding, location of ... scoring. ,Saga GT is second generation ... was initially developed at the University of ...
... Polynucleotide Kinase (PNK) catalyzes the transfer ... the 5'-hydroxyl of single- and double-stranded ... enzyme also removes the 3'-phosphate from ... 3', 5'-diphosphates to form a 3'-hydroxyl ...
Request Info...
Biology Products: