Navigation Links
Transplanted adult stem cells provide lasting help to injured hearts
Date:5/7/2010

HOUSTON Human adult stem cells injected around the damage caused by a heart attack survived in the heart and improved its pumping efficiency for a year in a mouse model, researchers at The University of Texas MD Anderson Cancer Center report online ahead of publication in Circulation Research.

The study, with researchers at the Texas Heart Institute at St. Luke's Episcopal Hospital, used innovative imaging techniques developed by researchers at MD Anderson to track the stem cells' location and performance over time.

Injection of a patient's own adult stem cells into the heart has shown some efficacy in assisting recovery after a heart attack in early human clinical trials, said study senior author Edward T. H. Yeh, M.D., professor and chair of MD Anderson's Department of Cardiology.

"But nobody knows how they work, or how long the stem cells last and function in the heart," Yeh said. "This study shows how one type of adult stem cell works."

The team's research focused on adult stem cells those that can differentiate into a limited variety of tissues that circulate in the blood and are distinguished by the presence of the CD34 protein on the cell surface. These CD34-positive cells usually differentiate into blood vessel cells, also known as endothelial cells.

Earlier research by Yeh and colleagues showed CD34+ cells are capable of becoming heart muscle cells, called cardiomyocytes, blood vessel cells and smooth muscle cells.

A series of experiments showed:

  • The CD34+ cells survived in the left ventricle of the heart for 12 months or longer.

  • Left ventricular ejection fraction a measure of how much blood is pumped from the heart to other organs at each contraction improved in treated mice compared with controls for 52 weeks. LVEF went from 50 percent at baseline to 37 percent after heart attack and treatment, compared with 51 percent and 28 percent in untreated mice.

    <
    '/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Transplanted fat cells restore function after spinal cord injury
2. Studies on imaging and tracking transplanted cells
3. Device protects transplanted pancreatic cells from the immune system
4. New period of brain plasticity created with transplanted embryonic cells
5. Meth exposure in young adults leads to long-term behavioral consequences
6. Deep into the machinery of adult fragile X
7. Adult brain can change, study confirms
8. For migrating sparrows, kids have a compass, but adults have the map
9. New book defines promising young field of adult neurogenesis
10. Young chimps top adult humans in numerical memory
11. Mechanism for regulation of growth and differentiation of adult muscle stem cells is revealed
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Increasing adoption in ... to drive biometric systems market in ... According to a recently released TechSci Research ... biometric systems market in Saudi Arabia ... CAGR of over 22% through 2020. The market ...
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... by eating the leaves of an invasive tree that soaks ... down water loss in the Southwestern United States. Two ... U.S. Geological Survey and the U.S. Department of Agriculture, have ... result from using Asian beetles for the biological control of ...
... WEST LAFAYETTE, Ind. - A Purdue University scientist and ... improved plant growth regulators that are expected to be ... of horticulture, said the growth inhibitors block the transport ... the plant, controls growth processes. Current growth regulators that ...
... whose work has overtones of Indiana Jones as they ... that could become the source of life-saving new medicines, ... international agreement on biodiversity will affect their work. That,s ... News (C&EN), ACS,s weekly newsmagazine. C&EN Associate ...
Cached Biology News:Scientists study control of invasive tree in western US 2Scientists study control of invasive tree in western US 3New growth inhibitors more effective in plants, less toxic to people 2
(Date:4/16/2015)... -- Schulman Associates IRB, Inc., the industry-leading central IRB in ... on Laboratory Drive in the heart of ... will house review board and service staff, which will ... customer service to clients. CBRE | ... deal, while Capital Associates Management, LLC represented the landlord.   ...
(Date:4/16/2015)... According to the 2014 Liberty Mutual ... was ranked first among the leading causes of ... pushing, pulling, holding, carrying, or throwing and cost ... Round Company takes statistics like this very seriously. ... develop and design equipment that prevents these injuries ...
(Date:4/16/2015)... 2015 The Council for Agricultural ... 2015 Borlaug CAST Communication Award goes to Dr. ... University in Alabama. Award nominees must demonstrate an ... and/or the use of television, radio, or other ... As a specialist in the field of plant ...
(Date:4/16/2015)... - Portage Biotech Inc. ("Portage" or "the Company" )) ... to announce that the Company will be presenting  at ... be held in London, UK . ... James Mellon , a director of Portage, will ... programs at its subsidiaries, Portage Pharmaceuticals Ltd. ("PPL"), and ...
Breaking Biology Technology:Schulman IRB to Open Office in Research Triangle Park, N.C. 2The David Round Company Helps Companies Meet OSHA Standards by Combining Safety, Ergonomics, and Productivity 2The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Portage to Present at Master Investor 2015 in London, UK 2Portage to Present at Master Investor 2015 in London, UK 3Portage to Present at Master Investor 2015 in London, UK 4
... Biopharmaceuticals (Nasdaq: KERX ) today announced completion ... its Phase 3 registration program of Zerenex™, the Company,s ... serum phosphorus levels, or hyperphosphatemia, in patients with end-stage ... registration program, which is being conducted pursuant to a ...
... NEW HAVEN, Conn., Sept. 19, 2011 The U.S. ... of allowance related to Cenestra Health,s high-purity omega-3 fatty ... claims cover a range of high-purity omega-3 formulations including ... Cenestra Health was issued U.S. Patent No. ...
... 16, 2011 Generex Biotechnology Corporation ( www.generex.com ... Napolii, from University Campus Bio-Medico in Rome, Italy, ... on Generex Oral-lyn™ buccal insulin spray on September ... Study of Diabetes (EASD) annual meeting in Lisbon, ...
Cached Biology Technology:Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in Zerenex™ (Ferric Citrate) Phase 3 Long-Term Study 2Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in Zerenex™ (Ferric Citrate) Phase 3 Long-Term Study 3Keryx Biopharmaceuticals Announces Completion of Patient Enrollment in Zerenex™ (Ferric Citrate) Phase 3 Long-Term Study 4Cenestra Health Issued Notice of Allowance: Expands Patent Range of High-Purity Omega-3 Fatty Acid Formulations 2Cenestra Health Issued Notice of Allowance: Expands Patent Range of High-Purity Omega-3 Fatty Acid Formulations 3Generex Makes Podium Presentation of Clinical Data on Generex Oral-lyn™ at European Association for the Study of Diabetes Annual Meeting 2Generex Makes Podium Presentation of Clinical Data on Generex Oral-lyn™ at European Association for the Study of Diabetes Annual Meeting 3Generex Makes Podium Presentation of Clinical Data on Generex Oral-lyn™ at European Association for the Study of Diabetes Annual Meeting 4
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... number is a new product number, ... number. If showing no availability yet, ... number (Z71,517-4) or contact customer service ... (expanded surface, easy grip) ...
Formula variant: With macro- and micronutrients. Physical Form: powder Suitab tst: plant cell culture tested...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap. (2/sp, 20/ca) Packaging: 2 / pack, 20 /...
Biology Products: