Navigation Links
Transmission routes of spreading protein particles
Date:3/27/2013

in mammalian cells. "At first, our mouse cells produced the protein, but no particles formed," Vorberg reports. "The situation changed when we exposed the cells to aggregates of the same protein. Suddenly, the proteins which had been in solution started building clumps."

Diffusing aggregates

Once this reaction had been triggered the cells went on producing aggregates. The researchers noticed that these clumps spread into neighboring cells, where they initiated synthesis of further aggregates.

"We have experimentally shown that certain protein particles originating from the cytosol, i. e. from inside the cells, are able to spread between cells. This means that in mammalian cells there are mechanisms capable of triggering such a chain reaction. Accordingly, what we have shown in our model system may be applicable to neurodegenerative diseases," Vorberg comments.

Propagation of aggregates was most effective between adjacent cells. "At least in our model system, protein particles are not released efficiently into the medium and assimilated by neighboring cells. The most effective transmission happens by direct cell-to-cell contact. It is possible that cells form protrusions and that aggregates move from one cell to the next through this connection", says the neuroscientist. What is happening here will be the focus of further research.

Basis for potential therapies

"It is important to know how protein particles disseminate", Vorberg emphasizes. "Disease-related protein particles might propagate in a similar way to the model protein we investigated." Unraveling the mechanism for transmission between cells could lead to new methods for treatment. "If we find a way to prevent the spreading of disease-related protein particles, we might be able to interfere with the progression of the diseases," Vorberg says.


'/>"/>

Contact: Dirk Förger
dirk.foerger@dzne.de
49-228-433-02260
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. New study discovers powerful function of single protein that controls neurotransmission
2. Analyzing disease transmission at the community level
3. A brain filter for clear information transmission
4. Pigs look healthy but test positive for flu at fairs; transmission seen between pigs and humans
5. Preventing obesity transmission during pregnancy
6. Biodiversity does not reduce transmission of disease from animals to humans
7. Sequencing tracks animal-to-human transmission of bacterial pathogens
8. How bumblebees find efficient routes without a GPS
9. New model of disease contagion ranks US airports in terms of their spreading influence
10. Flightless molecule may prevent cancer from spreading from 1 tissue to another
11. Frequent traveller: Dysentery-causing bacteria spreading from Europe to Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/18/2014)... referred for evaluation of suspected genetic conditions, whole-exome ... percent, including detection of a number of rare ... according to a study appearing in JAMA ... with the American Society of Human Genetics annual ... coding regions of thousands of genes simultaneously using ...
(Date:10/17/2014)... is available in German . ... very few drugs. When treating overdoses, doctors are often limited ... difficult if there is a combination of drugs involved. So ... accidentally swallows his grandmother,s pills? ETH professor Jean-Christophe Leroux from ... find an answer to this question. "The task was to ...
(Date:10/16/2014)... cultivated efficiently, they are anything but sustainable: environmental ... cultivation is becoming increasingly evident. Despite their disadvantages, ... are regarded as the sole possibility of achieving ... finds Bernhard Schmid, an ecology professor at the ... of agriculture and forestry. After all, a new ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Emergency aid for overdoses 2Emergency aid for overdoses 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... Researchers have discovered an isolated, self-sustaining, bacterial community living ... surface in a South African gold mine. It is ... on geologically produced sulfur and hydrogen and one of ... depend on energy from the Sun in any way. ...
... risks of a manned flight to Mars ranks the possibility ... the brains of astronauts, leaving them in a vegetative state, ... NASA's Mars scientists, the cosmic radiation risk remains a show-stopper ... too heavy to reach Mars, which, at its closest, is ...
... iguanas on the Galápagos Islands live without predators - at ... Since then they have been confronted with cats and dogs ... therefore a suitable model of study in order to discover ... behaviour and endocrine stress response to novel predation threats. Scientists ...
Cached Biology News:Otherworldly bacteria discovered two miles down 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 2Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 3Mars mission Risk 29: Scientists research ways to reduce radiation-induced brain damage 4Too mellow for our predatory world 2Too mellow for our predatory world 3Too mellow for our predatory world 4
(Date:10/20/2014)... Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced four new ... and provides a good start to Q4.  The orders are for ... and one in the Middle East . ... Peter Bruijns , President & CEO. "Total bidding activity and ... have been for any complete year since the company has tracked ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 ... Partners LLC, announced today that Ellen Teplitzky, an ... support for the pharmaceutical industry, has joined the ... of its legal services practice. NDA Partners ... expert witness and testimony, to top law firms ...
(Date:10/19/2014)... The Asia-Pacific Bromine Market report defines and ... and forecast of revenue. , Browse through the ... to get an idea of the in-depth analysis ... segmentation in the Asia-Pacific bromine market, and is ... http://www.micromarketmonitor.com/market/asia-pacific-bromine-6741503144.html , Bromine is a volatile ...
(Date:10/19/2014)... The report "Unmanned Ground Vehicle Market by Application ... & by Geography - Forecasts & Analysis 2014–2020", ... market into various sub segments with an in-depth ... also identifies the factors driving this market, various ... adoption trends. , The unmanned ground vehicle market ...
Breaking Biology Technology:NDA Partners Appoints Ellen Teplitzky, JD as Director of its Legal Services Practice 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 2The Asia-Pacific Bromine Market is estimated to grow to $4,080.1 million by 2018 - New Report by MicroMarket Monitor 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 2Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 3Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 4Unmanned Ground Vehicle (UGV) Market Estimated to Reach $8.26 Billion by 2020 - New Research Report by MarketsandMarkets 5
... Germany , June 16, 2010 ,The medical devices company joimax(R) GmbH is ... had already been the motto of,the last company move back in 2005. , ... The US market has an enormous ... to Irvine, California , one,of high-tech industry centers in the United States ...
... This release is avaiable in French . ... of high-tech products such as computer displays or solar ... chemical composition as inorganic materials, preventing scientists from using ... of researchers led by McGill,s Dr. Dmitrii Perepichka and ...
... June 15 BioMed Realty Trust, Inc. (NYSE: BMR ) ... of $0.15 per share of common stock, representing a 7.1% increase over ... is equivalent to an annualized dividend of $0.60 per common share. ... BioMed also announced that its board of directors ...
Cached Biology Technology:joimax(R) Moves Into Larger Premises 2Organic nanoelectronics a step closer 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 2BioMed Realty Trust Declares Second Quarter 2010 Common Stock and Preferred Stock Dividends 3
Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C Terminus of the protein sequence according to NP_055196....
Rabbit polyclonal to NMDAR1 e/f/g/h ( Abpromise for all tested applications)....
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
Biology Products: