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Transitioning epithelial cells to mesenchymal cells enhances cardiac protectivity
Date:12/23/2013

ltimately aided their mobility and altered their secretions.

One direct result of the EMT-AEC treatment was that EMT-AEC-treated hearts displayed "better global systolic function and improved longitudinal strain rate in the area of interest."

The researchers added that while AECs may be useful in the context of cardiovascular regeneration, it is unclear whether the usefulness requires "actual stemness" or "pluripotency-unrelated secretory mechanisms."

"Blood vessel density was increased in both AEC and EMT-AEC-treated hearts and we conclude that EMT enhances the cardioprotective effects of human AECs," they wrote.

"This study highlights how AECs are a potentially useful stem cell population whose use can be maximized by a transformation, such as EMT, prior to transplantation" said Dr Amit N. Patel, director of cardiovascular regenerative medicine at the University of Utah and section editor for Cell Transplantation. "This was demonstrated in a myocardial infarction model but further study is necessary to confirm whether this transformation is relevant for other diseases (and other cell types)".


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Contact: Robert Miranda
cogcomm@aol.com
Cell Transplantation Center of Excellence for Aging and Brain Repair
Source:Eurekalert

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