Navigation Links
Transgenic technique to 'eliminate' a specific neural circuit of the brain in primates
Date:6/26/2012

In the brains of humans and non-human primates, over 100 billion nerve cells build up complicated neural circuits and produce higher brain functions. When an attempt is made to perform gene therapy for neurological diseases like Parkinson's disease, it is necessary to specify a responsible neural circuit out of many complicated circuits. Until now, however, it was difficult to introduce a target gene into this particular circuit selectively. The collaborative research group consisting of Professor Masahiko TAKADA from Primate Research Institute, Kyoto University, Professor Atsushi NAMBU from National Institute for Physiological Sciences, National Institutes of Natural Sciences, and Professor Kazuto KOBAYASHI from Fukushima Medical University School of Medicine succeeded in development of the gene transfer technique that can "eliminate"a specific neural circuit in non-human primates for the first time in the world .

They applied this technique to the basal ganglia, the brain region that is affected in movement disorders such as Parkinson's disease, and successfully eliminated a particular circuit selectively to elucidate its functional role. This technique can be applied to gene therapy for various neurological diseases in humans. This research achievement was supported by the Strategic Research Program of Brain Sciences by MEXT of Japan, and published in the American science magazine PLoS ONE (June 25th issue electronic edition).

The research group developed a special viral vector, NeuRet-IL-2R alpha-GFP viral vector, expressing human interleukin type 2 alpha receptor, which the cell death inducer immunotoxin binds. Nerve cells transfected with this viral vector cause cell death by immunotoxin. First, the research group injected the viral vector into the subthalamic nucleus that is a component of the basal ganglia. Then, they injected immunotoxin into the motor cortex, an area of the cerebral cortex that controls movement, and succeed i
'/>"/>

Contact: Atsushi Nambu
nambu@nips.ac.jp
81-564-557-771
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Blossom end rot plummets in Purdue-developed transgenic tomato
2. New synthetic biology technique boosts microbial production of diesel fuel
3. New genetic bar code technique establishes ability to derive DNA information from RNA
4. Early detection techniques offer hope for improved outcomes in lung cancer patients
5. Scientists develop new technique that could improve heart attack prediction
6. New rearing system may aid sterile insect technique against mosquitoes
7. Its a trap! New laboratory technique captures microRNA targets
8. New screening technique yields elusive compounds to block immune-regulating enzyme
9. New stem cell technique promises abundance of key heart cells
10. Evaluation of microscopy techniques may help scientists to better understand ancient plants
11. New technique allows simulation of noncrystalline materials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... , May 11, 2015 Curemark LLC, a ... start of a new Phase III double blind, randomized, ... novel formulation, CM-AT, on all children ages 3-8 with ... FDA Phase III double blinded clinical trial for CM-AT ... levels of the digestive enzyme chymotrypsin. This new trial ...
(Date:5/6/2015)... AVIV, Israel , May 6, 2015 ... world,s most established helmet producer, announced today that they ... Smart Helmet, the world,s first bio-sensing cycling helmet and ... be released in two new colors in order to ... for the product. In addition, LifeBEAM and Lazer announced ...
(Date:4/27/2015)... Fla. , Apr. 27, 2015 Profile ... access control and security systems is pleased to announce ... company as a consultant and member of its scientific ... is widely known as a thought leader in technology-enhanced ... Learning Technology Group, and has published studies and books ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... Emory University School of Medicine have obtained a detailed ... key immune system genes. The finding could help ... drugs with fewer side effects. The results are ... Nature Structural & Molecular Biology . Synthetic ...
... du Sud, 7 décembre 2012 Integrated Biometrics, ... technologique grâce à la certification par le FBI ... développement d,IB a créé un nouveau produit en ... Sensor (LES) ainsi qu,à un transistor en couches ...
... humans interbreed and produce offspring of mixed ancestry? ... with anatomically modern humans tens of thousands of years ... human gene pool. But the findings are not universally ... clarify the role of interbreeding, which is also known ...
Cached Biology News:Steroid hormone receptor prefers working alone to shut off immune system genes 2Integrated Biometrics présente Sherlock, le capteur d'empreintes digitales le plus léger, le plus mince et le plus petit, certifié conformément à l'Annexe F Mobile ID 2Monkey business: What howler monkeys can tell us about the role of interbreeding in human evolution 2Monkey business: What howler monkeys can tell us about the role of interbreeding in human evolution 3
(Date:5/26/2015)... Just the characterization of being a new ... does not guarantee immediate acceptance. In particular, a ... prior failures is often met with significant skepticism. ... irony that is often an unappreciated aspect of scientific ... Asymmetrex has found that building acceptance of its ...
(Date:5/22/2015)... DUBLIN , May 22, 2015  Actavis plc ... of the U.S. Court of Appeals for the Second ... 2014 preliminary injunction requiring the Company to continue distribution ... Logo - http://photos.prnewswire.com/prnh/20130124/NY47381LOGO   ... uphold this ruling, we intend to continue our strong ...
(Date:5/21/2015)... 21, 2015 /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or ... that develops and commercializes proprietary technologies and products for ... results for the second fiscal quarter ended March 31, ... continued to advance business with our existing customers and ... President and CEO of SQI. "The delivery of a ...
(Date:5/21/2015)... San Francisco, CA (PRWEB) May 21, 2015 ... microbiome sequencing, has announced a partnership with PicnicHealth, ... records for patients. Participants diagnosed with Inflammatory Bowel ... as well as a complementary uBiome research kit. ... Summer 2014. , For more ...
Breaking Biology Technology:In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 2In August Asymmetrex Will Present Details of Its Crowdsourcing Campaign to Determine the Extent of Application of New Technologies for Counting Adult Tissue Stem Cells 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 2Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 3Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 4Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 5Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 6Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 7Actavis Confirms Appeals Court Ruling Requiring Continued Distribution of NAMENDA IR 8SQI Diagnostics Reports Second Quarter Financial Results 2SQI Diagnostics Reports Second Quarter Financial Results 3SQI Diagnostics Reports Second Quarter Financial Results 4SQI Diagnostics Reports Second Quarter Financial Results 5SQI Diagnostics Reports Second Quarter Financial Results 6SQI Diagnostics Reports Second Quarter Financial Results 7SQI Diagnostics Reports Second Quarter Financial Results 8uBiome Partners with PicnicHealth 2uBiome Partners with PicnicHealth 3
... In an address to,shareholders at the company,s annual ... Chairman and CEO David B. Snow Jr. today ... to deliver strong,continuing earnings growth through 2008 and ... pharmacy to retaining and winning,customers, and advanced clinical ...
... Detects Extravasations during CT ... Contrast ... today,that its XDS(TM) Extravasation Detector has received a 2008 Medical ... in the,detection of leaking intravenous contrast media from the injection ...
... 22 Nektar,Therapeutics (Nasdaq: NKTR ) announced ... Company as Chief Operating Officer and Head of ... all aspects of the PEGylation Business Unit, including ... Company. He will also,serve as Chairman of Nektar ...
Cached Biology Technology:Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 2Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 3Medco CEO to Shareholders: Delivering Results, Driving Shareholder Value 4MEDRAD(R) XDS(TM) Extravasation Detector Wins Medical Design Excellence Award 2MEDRAD(R) XDS(TM) Extravasation Detector Wins Medical Design Excellence Award 3Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 2Bharatt Chowrira Joins Nektar Therapeutics as Chief Operating Officer and Head of PEGylation Business Unit 3
... 0.1 mL - 25 mL pipets ,Angled acrylic ... most standard square or round pipet cans. Constructed of ... each 76 mm W x 76 mm H x ... ins.). Overall dimensions: 89 mm W x 406 mm ...
... contains choice of PDMS Stamps (3 PDMS ... 200 micron squares or 100 um x ... mm lines, 3 PDMS nano-patterned stamps with ... and pitch of 400 nm, or 3 ...
Request Info...
RECOMBINANT EQUINE IL-4 Product Type: Recombinant Protein...
Biology Products: