Navigation Links
Transforming skin cells into stem cells using a molecular toolkit
Date:2/18/2010

In an effort to sidestep the ethical dilemma involved in using human embryonic stem cells to treat diseases, scientists are developing non-controversial alternatives: In particular, they are looking for drug-like chemical compounds that can transform adult skin cells into the stem cells now obtained from human embryos. That's the topic of a fascinating article in Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.

C&EN Associate Editor Sarah Everts notes that in 2006, researchers in Japan figured out a way to use genetic engineering to coax a skin cell to become a so-called "pluripotent" stem cell a type of cell that can potentially morph or change into any cell of the human body. The scientists achieved the result by infecting the skin cell with a virus containing certain genes instructing the cell to change.

Now chemists are trying to reproduce this cellular alchemy with drug-like substances because gene therapies have faced trouble getting into the clinic. Scientists are looking for chemical ways to go backward in cell development to reprogram mature cells into stem cells. Others are trying to identify substances that can morph one cell directly into other cell types for example, from a skin cell directly into a nerve cell that might treat Parkinson's disease without the use of stem cells at all. The ultimate goal is to be able to reprogram any cell of the body into another by means of a simple molecular kit, the article notes. But as chemists start putting together toolkits with these drug-like molecules, they face many technical hurdles as well as challenges getting acceptance from the stem cell community.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
2. NIH expands national consortium dedicated to transforming clinical and translational research
3. Lifes smallest motor, cargo carrier of the cells, moves like a seesaw
4. Induced neural stem cells: Not quite ready for prime time
5. Biologists image birth of blood-forming stem cells in embryo
6. Research team targets self-cannibalizing cancer cells
7. Communication breakdown: what happens to nerve cells in Parkinsons disease
8. Cells can read damaged DNA without missing a beat
9. Virus-free technique enables Stanford scientists to easily make stem cells pluripotent
10. Cord blood-derived CD133+ cells improve cardiac function after myocardial infarction
11. Cells send dirty laundry home to mom
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ... of online age and identity verification solutions, announced today ... Identity Conference 2017, May 15 thru May 17, 2017, ... Building and International Trade Center. Identity ... globe and in today,s quickly evolving digital world, defining ...
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/11/2017)... Apr. 11, 2017 Research and Markets has ... report to their offering. ... The global eye tracking market to grow at a CAGR of ... Eye Tracking Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Biology News(10 mins):
(Date:7/18/2017)... ... July 18, 2017 , ... G-CON today announced ... Trademark Office for its Patent Applications 14/858,857 and 13/669,785 both entitled Modular, Self-Contained, ... applications further expand the protection of G-CON’s R&D investments and validate the G-CON ...
(Date:7/17/2017)... ... July 17, 2017 , ... Whitehouse ... testing capabilities to encompass the full series of ISO 80369 standard test procedures. ... for medical device and drug delivery systems. With this recent expansion, Whitehouse Labs ...
(Date:7/17/2017)... ... July 17, 2017 , ... Neurodevelopmental ... wide range of overlapping clinical features. The advancement of targeted next-generation sequencing (NGS) ... NDD research and testing. , However, designing a custom panel for disease ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... instruments announced the launch of its new line of Rocking and Waving Shakers ... waving shaker models (both analog and digital) for laboratory applications in a variety ...
Breaking Biology Technology: