Navigation Links
Transforming skin cells into stem cells using a molecular toolkit
Date:2/18/2010

In an effort to sidestep the ethical dilemma involved in using human embryonic stem cells to treat diseases, scientists are developing non-controversial alternatives: In particular, they are looking for drug-like chemical compounds that can transform adult skin cells into the stem cells now obtained from human embryos. That's the topic of a fascinating article in Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.

C&EN Associate Editor Sarah Everts notes that in 2006, researchers in Japan figured out a way to use genetic engineering to coax a skin cell to become a so-called "pluripotent" stem cell a type of cell that can potentially morph or change into any cell of the human body. The scientists achieved the result by infecting the skin cell with a virus containing certain genes instructing the cell to change.

Now chemists are trying to reproduce this cellular alchemy with drug-like substances because gene therapies have faced trouble getting into the clinic. Scientists are looking for chemical ways to go backward in cell development to reprogram mature cells into stem cells. Others are trying to identify substances that can morph one cell directly into other cell types for example, from a skin cell directly into a nerve cell that might treat Parkinson's disease without the use of stem cells at all. The ultimate goal is to be able to reprogram any cell of the body into another by means of a simple molecular kit, the article notes. But as chemists start putting together toolkits with these drug-like molecules, they face many technical hurdles as well as challenges getting acceptance from the stem cell community.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
2. NIH expands national consortium dedicated to transforming clinical and translational research
3. Lifes smallest motor, cargo carrier of the cells, moves like a seesaw
4. Induced neural stem cells: Not quite ready for prime time
5. Biologists image birth of blood-forming stem cells in embryo
6. Research team targets self-cannibalizing cancer cells
7. Communication breakdown: what happens to nerve cells in Parkinsons disease
8. Cells can read damaged DNA without missing a beat
9. Virus-free technique enables Stanford scientists to easily make stem cells pluripotent
10. Cord blood-derived CD133+ cells improve cardiac function after myocardial infarction
11. Cells send dirty laundry home to mom
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... -- Research and Markets has announced the ...  report to their offering.  , ,     (Logo: ... forecast the global multimodal biometrics market to grow ... 2016-2020.  Multimodal biometrics is being implemented ... healthcare, BFSI, transportation, automotive, and government for controlling ...
(Date:4/15/2016)... Research and Markets has announced ... 2016-2020,"  report to their offering.  , ... global gait biometrics market is expected to grow ... 2016-2020. Gait analysis generates multiple variables ... to compute factors that are not or cannot ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
Breaking Biology News(10 mins):
(Date:4/27/2016)... (PRWEB) , ... April 27, 2016 , ... Global ... the GSCG Advisory Board. Ross is the founder of GSCG affiliate Kimera Labs in ... Miami, where he studied hematopoietic stem cell transplantation for hematologic disorders and the suppression ...
(Date:4/27/2016)... 2016 MedDay, a biotechnology company focused ... appointment of Catherine Moukheibir as Chairman of its Board of ... Jean Jacques Garaud , who contributed to the rapid development ... Catherine started her career in strategy consulting and ... London .  She held C-Suite level roles in ...
(Date:4/26/2016)... ANGELES, Calif. (PRWEB) , ... April 27, 2016 ... ... Angeles office of Lewis Roca Rothgerber Christie LLP as an associate in the ... prosecuting U.S. and international electrical, mechanical and electromechanical patent applications. He has an ...
(Date:4/26/2016)... ... April 26, 2016 , ... The European Patent Office (EPO) ... of three finalists for the European Inventor Award 2016 in the category "Non-European countries." ... announced at a ceremony in Lisbon on June 9th. , The human capacity to ...
Breaking Biology Technology: