Navigation Links
Transforming cancer treatment
Date:7/11/2012

A Harvard researcher studying the evolution of drug resistance in cancer is predicting that, in a few decades, "many, many cancers could be manageable."

Martin Nowak, a Harvard Professor of Mathematics and of Biology and Director of the Program for Evolutionary Dynamics, is one of several co-authors of a paper, published in Nature, that details how resistance to targeted drug therapy emerges in colorectal cancers, and suggests a new, multi-drug approach to treatment could make many cancers manageable, if not curable, illnesses.

The key, Nowak's research suggests, is to change the way clinicians battle the disease.

Though physicians and researchers in recent years have increasingly turned to "targeted therapies" new drugs which combat cancer by interrupting its ability to grow and spread rather than traditional chemotherapy, the treatment is far from perfect. Most are only effective for a few months before the cancer evolves resistance to the drugs and is able to grow unchecked.

In the particular colon cancer treatment that was the subject of Nowak's research, the culprit is the KRAS gene. Normally responsible for producing a protein to regulate cell division, when activated, the gene helps cancer cells develop resistance to targeted therapy drugs, effectively making the treatment useless.

Based on analysis completed by Benjamin Allen, a Post-Doctoral Fellow in Mathematical Biology, and Ivana Bozic, a Post-Doctoral Fellow in Mathematics, Nowak's research suggests that, of the billions of cancer cells that exist in a patient, only a tiny percentage about one in a million are resistant to drugs used in targeted therapy. When treatment starts, the non-resistant cells are wiped out. The few resistant cells, however, quickly repopulate the cancer, causing the treatment to fail.

The answer, Nowak argued, is simple rather than the one drug used in targeted therapy, treatments must involve at least t
'/>"/>

Contact: Peter Reuell
preuell@fas.harvard.edu
617-496-8070
Harvard University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Preclinical studies use specialized ultrasound to detect presence of cancer
2. Cancer Cell article shows first evidence for targeting of Pol I as new approach to cancer therapy
3. Researchers discover molecule in immune system that could help treat dangerous skin cancer
4. Stanford scientists find molecule to starve lung cancer and improve ventilator recovery
5. Tumor microenvironment helps skin cancer cells resist drug treatment
6. Cancer scientists link ‘oncometabolite’ to onset of acute myeloid leukemia
7. The genomics symposium to boost the further development of cancer research
8. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
9. Regulation of telomerase in stem cells and cancer cells
10. 5th Latin American Conference on Lung Cancer
11. Husband-wife team set out to improve breast cancer exams
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/19/2015)... Feb .19, 2015 Research and Markets ... of the "Military Electro-Optical / Infrared Systems ... by Platform - Forecast to 2020" report ... electro-optical/infrared systems market is expected to reach $16.35 ... 7.71%. This report segments the military ...
(Date:2/13/2015)... Feb. 13, 2015 ACT Genomics Co., ... aims to transform cancer genomic information into precision ... company has raised US$ 8 million in the its ... Taipei, Taiwan , ACT Genomics ... With the aim to implement next generation sequencing ...
(Date:2/12/2015)... , Feb. 12, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... filed provisional patent 62/113114 for DISTRIBUTED METHOD ... The patent further establishes NXT-ID,s position in ... intellectual property portfolio the ability for multiple devices to ...
Breaking Biology News(10 mins):Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3ACT Genomics Raises $8 Million in its First Private Funding Round 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3
... do a herd of gazelles and a fluffy mass ... describes the population dynamics of such prey animals as ... the relationship between cloud systems, rain and tiny floating ... understand, among other things, how human-produced aerosols affect rainfall ...
... several outbreaks of West Nile Virus, which causes fever or ... by blood-sucking mosquitoes, have been seen in the U.S., usually ... virus migrated here and they don,t know how, or ... of Tel Aviv University,s School of Public Health at the ...
... Northwest Forest Plan enacted in 1993 was designed to conserve ... owl, but researchers conclude in a new study that it ... on public lands. When forest harvest levels fell 82 ... of this act, they became a significant carbon "sink" for ...
Cached Biology News:Eat, prey, rain 2Catching the West Nile virus in action 2Northwest Forest Plan has unintended benefit - carbon sequestration 2
(Date:3/2/2015)... In the five years to 2015, the ... growth. The industry, which consists of companies that perform ... other goods, has grown on account of an improving ... IBISWorld forecasts that industry revenue will increase at an ... the five-year period, including an anticipated increase of 2.8% ...
(Date:3/2/2015)... GAITHERSBURG, Md. , March 2, 2015 /PRNewswire/ ... Gaithersburg -based biotechnology company focusing on the ... and next generation antibody agents based upon a ... received a 2015 Life Sciences Impact Grant Award ... (MCDED).  The grant, created by MCDED, is awarded ...
(Date:3/2/2015)... , March 2, 2015 ... healthy whole food nutrition products reveal technological advancements ... related disorders such as hyperglycemia, obesity, insulin level ... Nutraceutical and Biotech Companies in focus today are: RiceBran ... Foods Ltd. (NYSE: ANFI ), CEL-SCI ...
(Date:3/2/2015)... Calif. , March 2, 2015 ... company developing therapies for autoimmune and infectious diseases, ... (USPTO) has issued an important new composition of ... function through the targeting of CLIP. ... peptide technology underlying VG Life Sciences, VG1177, a ...
Breaking Biology Technology:Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 2Laboratory Testing Services in Canada Industry Market Research Report Now Available from IBISWorld 3VLP Therapeutics Wins the 2015 Life Sciences Impact Grant Award from the Montgomery County Department of Economic Development 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 2Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 3Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 4Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 5Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 6Clinical Studies & Research Substantiate Claims That Company's Targeted Healthy Nutritional Products Promote Healthy Lipids, Glucose & Insulin Levels 7VG Life Sciences Granted Key Composition Of Matter Patent 2VG Life Sciences Granted Key Composition Of Matter Patent 3
... know there are at least five different types of patent ... (1) a search for competitors patents, (2) a clearance search, ... a patent validity search. Each type of search has a ... for competitors patents ,A search for competitors patents is ...
... business. , ,I call it the "humanizing factor" at work. A ... corporate world and the behavior of people in it, but in ... regular people at work (sometimes when you least expect it). , ... examples of the HF in action. , ,A friend goes on ...
... at a Senate appearance earlier this year. Credit: U.S. ... and Human Services Secretary Tommy Thompson announced Wednesday the ... national health information infrastructure in 10 years and bring ... also released a report, prepared by National Health IT ...
Cached Biology Technology:Five ways your company can benefit from patent searches 2Five ways your company can benefit from patent searches 3'Don't work here' job interviews set new Midwest technology trend 2'Don't work here' job interviews set new Midwest technology trend 3'Don't work here' job interviews set new Midwest technology trend 4'Don't work here' job interviews set new Midwest technology trend 5Thompson announces 'Decade of Health Information Technology' 2Thompson announces 'Decade of Health Information Technology' 3Thompson announces 'Decade of Health Information Technology' 4Thompson announces 'Decade of Health Information Technology' 5Thompson announces 'Decade of Health Information Technology' 6
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
... monitoring Aldolase tests. 2 levels of ... manufacturing values at 4 ± 2 ... 30-day shelf life once opened ... 1: 3 x 3 ml; Level ...
Human VEGF-D Biotinylated MAb (Clone 78923)...
Mouse Wnt-11 Affinity Purified Polyclonal Ab...
Biology Products: