Navigation Links
Transcription factor may protect against hepatic injury caused by hepatitis C and alcohol
Date:11/10/2013

icology, and Therapeutics, also report that FOXO3 protects against acute ethanol-induced steatosis and liver injury. This study demonstrates that FOXO3 is necessary for activation of autophagy, a cellular degradation pathway that protects against alcohol-induced liver injury by removing damaged mitochondria. Acute alcohol-treated FOXO3-deficient mice developed more severe liver injury than that of wild-type mice, and this was attributed to decreased expression of autophagy-related genes.

"Our study," says Dr. Ding, "was an acute alcohol model whereas the study in Dr. Weinman's laboratory was a chronic alcohol feeding model; however, both studies show that FOXO3 is protective. Thus, these results indicate that FOXO3 is an important general mechanism by activating multiple cellular protective functions that the normal liver uses to resist the toxic effects of alcohol."


'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study demonstrates cells can acquire new functions through transcriptional regulatory network
2. Transcription factor Lyl-1 critical in producing early T-cell progenitors
3. NIH backs Rice University study of delay in gene transcription networks
4. Stay-at-home transcription factor prevents neurodegeneration
5. FASEB SRC announces: Mechanism and Regulation of Prokaryotic Transcription Conference
6. Environmental factors in Tiny Tims near fatal illness
7. Soy-based S-equol supplement reduces metabolic syndrome risk factors
8. From scourge to saint: E. coli bacteria becomes a factory - to make cheaper, faster pharmaceuticals
9. Impaired recovery of Atlantic cod -- forage fish or other factors?
10. Longer sleep times may counteract genetic factors related to weight gain
11. Molecule found that inhibits estrogen, key risk factor for endometrial and breast cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/14/2015)... , May 14, 2015  Verificient Technologies, ... verification and online remote proctoring, announced a ... (SaaS) company and creator of the Canvas ... the two companies will benefit from the ... As a fully integrated multifactor ...
(Date:5/8/2015)... Synaptics Inc. (NASDAQ: SYNA ), the leading ... the executive management team will present at the following investor ... Telecom Conference Date: May 18, 2015 Time: 10:40am ... Cowen and Company Technology, Media & ... The New York Palace Hotel, New York, NY ...
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
Breaking Biology News(10 mins):Verificient and Instructure Announce Alliance Partnership to Provide Online Proctoring for K-12 and Higher Education Institutions 2Synaptics to Present at Upcoming Investor Conferences 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3
... break down cellulose (chunks of wood pulp), a process ... chemicals like chlorine. Nature performs the same task using ... far less energy. The catch is that the enzymes ... hold up to the high temperatures of the manufacturing ...
... Technology (NIST) and in Lithuania have used a NIST-developed ... detect and measure a protein associated with a serious ... The work illustrates how the artificial membrane could be ... bacteria Gardnerella vaginalis , BV is a very ...
... This news release is available in German . ... the death of thousands of neurons in the brain. Nerve growth ... of the neurons; however, clinical tests with GDNF have not yielded ... Neurobiology in Martinsried and their colleagues have now succeeded in demonstrating ...
Cached Biology News:Expanding the range of nature's catalysts for industrial applications 2Expanding the range of nature's catalysts for industrial applications 3NIST cell membrane model studied as future diagnostic tool 2Parkinson gene: Nerve growth factor halts mitochondrial degeneration 2Parkinson gene: Nerve growth factor halts mitochondrial degeneration 3
(Date:6/1/2015)... MONTREAL and YONGIN, South Korea ... with great pride that Green Cross Biotherapeutics Inc. (GCBT) ... will be located on the Montreal Technoparc,s Saint-Laurent Campus. ... green field investment projects in Canada ... construction of the first intravenous immunoglobulin (IVIG) and albumin ...
(Date:6/1/2015)... 2015 About Bio-alcohols Bio-alcohols ... or cellulose. Bio-alcohols are primarily used in the transportation ... replacement for gasoline in cars. Technavio,s analysts forecast the ... 9 percent over the period 2014-2019. ... be segmented into five: transportation, infrastructure, medical, and others. ...
(Date:6/1/2015)... June 1, 2015 Research ... addition of the "Global PDT Machine Industry ...        (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... is a professional and in-depth study on the ... report provides a basic overview of the industry ...
(Date:6/1/2015)... , May 29, 2015 Research ... addition of the "Global Bioinformatics Market 2015-2019" ... analysts forecast the global bioinformatics market to grow ... 2014-2019. Bioinformatics is a field of science ... consists of information stored in DNA form and ...
Breaking Biology Technology:Green Cross Biotherapeutics Kicks Off Construction in Montreal 2Green Cross Biotherapeutics Kicks Off Construction in Montreal 3Global Bio-alcohols Market 2015-2019 2Global PDT Machine Industry Report 2014 2Global Bioinformatics Market 2015-2019 - Rapid Developments in Molecular Diagnostics 2Global Bioinformatics Market 2015-2019 - Rapid Developments in Molecular Diagnostics 3
... , MADEIRA BEACH, Fla. , ... – Mr. Diabetes®, Executive Director of Defeat Diabetes Foundation and ... the ProtoKinetix (PKTX) Advisory Board.  ProtoKinetix, Inc. is a biotechnology ... anti-aging glycoproteins (AAGP™) for medicine and the biotechnology and cosmetic ...
... , Editors say the new mission statement ... of biological research , BETHESDA, Md. , Jan. 14 ... week a number of changes to the journal,s publishing policies. They ... of biological research and will help the journal better meet the ...
... , , , , ... Sweden , January 14 Karolinska,Development AB and ... enrich the flow of investment opportunities available to,Karolinska Development and ... agreement involves evaluation of,potential investments; advise to existing portfolio companies ...
Cached Biology Technology:Andrew P. Mandell - Mr. Diabetes(R) to Sit On ProtoKinetix Advisory Board 2Journal of Biological Chemistry Changes Approach to Manuscript Reviews and Eliminates Submission Fees 2Journal of Biological Chemistry Changes Approach to Manuscript Reviews and Eliminates Submission Fees 3Karolinska Development and Uminova Invest Sign Co-operation Agreement 2
Nestin, Human...
Ezrin/Radixin/Moesin Antibody...
... Taura Syndrome Virus Coat Protein ... tested applications). ... MNDIPITNQN VVLSKNVTDN LFEVQDQALI ESLSRDVLLH NDSWTSSDDE ... terminal amino acids 25/100 of ...
JAB1 Immunogen: Synthetic peptide, conjugated to KLH, corresponding to residues S(201) E Y Q T I P L N K I E D F G V(216) of human JAB1. The sequence is identical in mouse and rat. Storage: -...
Biology Products: